Incidental Mutation 'IGL02285:Lypd4'
ID 289969
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lypd4
Ensembl Gene ENSMUSG00000062732
Gene Name Ly6/Plaur domain containing 4
Synonyms 4933400F01Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.134) question?
Stock # IGL02285
Quality Score
Status
Chromosome 7
Chromosomal Location 24564044-24569180 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24564865 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 91 (Q91L)
Ref Sequence ENSEMBL: ENSMUSP00000122913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011493] [ENSMUST00000079306] [ENSMUST00000122995] [ENSMUST00000170837]
AlphaFold Q8BVP6
Predicted Effect probably benign
Transcript: ENSMUST00000011493
SMART Domains Protein: ENSMUSP00000011493
Gene: ENSMUSG00000011349

DomainStartEndE-ValueType
DM 38 91 6.53e-21 SMART
low complexity region 163 189 N/A INTRINSIC
Pfam:DMRT-like 242 369 3.1e-54 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000079306
AA Change: Q91L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000078287
Gene: ENSMUSG00000062732
AA Change: Q91L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 142 233 7.5e-23 PFAM
low complexity region 237 244 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000122995
AA Change: Q91L

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000122913
Gene: ENSMUSG00000062732
AA Change: Q91L

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000170837
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205486
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago3 A G 4: 126,244,670 (GRCm39) V672A possibly damaging Het
Arhgef28 A T 13: 98,187,536 (GRCm39) V253D possibly damaging Het
Atg3 G A 16: 44,998,680 (GRCm39) probably benign Het
Camsap1 T C 2: 25,819,814 (GRCm39) D1557G probably damaging Het
Cdh20 A G 1: 110,065,921 (GRCm39) T732A probably damaging Het
Cert1 A G 13: 96,752,990 (GRCm39) H348R probably benign Het
Cyp3a13 T A 5: 137,908,229 (GRCm39) I207F probably benign Het
Dock1 T G 7: 134,683,649 (GRCm39) probably null Het
Drc7 A T 8: 95,797,861 (GRCm39) probably benign Het
Drosha C A 15: 12,833,950 (GRCm39) P18H unknown Het
Fbxl5 A G 5: 43,922,690 (GRCm39) S243P possibly damaging Het
Filip1 A G 9: 79,727,408 (GRCm39) C404R probably damaging Het
Gm5745 G A 9: 73,082,780 (GRCm39) noncoding transcript Het
Gm7808 T G 9: 19,839,347 (GRCm39) probably benign Het
Gpi-ps C T 8: 5,690,373 (GRCm39) noncoding transcript Het
Hcn3 T C 3: 89,060,119 (GRCm39) D175G probably damaging Het
Igkv1-117 A T 6: 68,098,519 (GRCm39) M23L probably benign Het
Kif26a A G 12: 112,123,941 (GRCm39) D182G probably damaging Het
Lmbr1 A G 5: 29,459,233 (GRCm39) probably benign Het
Ncoa5 C T 2: 164,844,760 (GRCm39) A37T probably damaging Het
Or52ad1 G A 7: 102,995,245 (GRCm39) R297* probably null Het
Or56b1 A G 7: 104,284,932 (GRCm39) E17G probably benign Het
Or7g17 T A 9: 18,768,286 (GRCm39) C122S possibly damaging Het
Ppp1r18 A G 17: 36,178,148 (GRCm39) K8E probably damaging Het
Ppp3ca A G 3: 136,634,387 (GRCm39) probably benign Het
Ptpn12 T A 5: 21,260,711 (GRCm39) Q12L probably benign Het
Rpgrip1l A G 8: 91,959,535 (GRCm39) F1122L possibly damaging Het
Rps15 G T 10: 80,129,596 (GRCm39) M43I probably benign Het
Rrp15 T C 1: 186,453,592 (GRCm39) probably benign Het
Sash1 A T 10: 8,616,098 (GRCm39) M588K probably damaging Het
Slc12a7 A G 13: 73,943,714 (GRCm39) probably benign Het
Slc25a13 A G 6: 6,042,643 (GRCm39) V587A possibly damaging Het
Sugct T C 13: 17,847,181 (GRCm39) D34G possibly damaging Het
Tdpoz2 T A 3: 93,559,598 (GRCm39) I125F probably damaging Het
Trim52 T A 14: 106,344,702 (GRCm39) L120Q probably damaging Het
Vmn1r85 T C 7: 12,818,711 (GRCm39) I144M probably damaging Het
Vmn2r107 T C 17: 20,595,823 (GRCm39) F792S probably damaging Het
Vsnl1 A G 12: 11,436,878 (GRCm39) F34L probably damaging Het
Other mutations in Lypd4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0012:Lypd4 UTSW 7 24,564,757 (GRCm39) missense probably damaging 1.00
R0012:Lypd4 UTSW 7 24,564,757 (GRCm39) missense probably damaging 1.00
R0355:Lypd4 UTSW 7 24,564,691 (GRCm39) missense probably benign 0.03
R0605:Lypd4 UTSW 7 24,564,800 (GRCm39) missense probably damaging 1.00
R1502:Lypd4 UTSW 7 24,566,253 (GRCm39) missense probably benign
R3721:Lypd4 UTSW 7 24,564,884 (GRCm39) missense probably benign 0.26
R4670:Lypd4 UTSW 7 24,566,151 (GRCm39) missense probably benign 0.06
R4835:Lypd4 UTSW 7 24,566,121 (GRCm39) missense probably benign 0.00
R5032:Lypd4 UTSW 7 24,566,240 (GRCm39) missense probably damaging 1.00
R5642:Lypd4 UTSW 7 24,564,604 (GRCm39) missense probably benign 0.01
R8141:Lypd4 UTSW 7 24,564,254 (GRCm39) missense possibly damaging 0.69
R9407:Lypd4 UTSW 7 24,566,160 (GRCm39) missense probably null 1.00
X0063:Lypd4 UTSW 7 24,564,811 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16