Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02288:Vmn2r70'

290015

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r70

Ensembl Gene

ENSMUSG00000090806

Gene Name

vomeronasal 2, receptor 70

Synonyms

EG620835

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

IGL02288

Quality Score

Status

Chromosome

Chromosomal Location

85207911-85218296 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 85214342 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Phenylalanine at position 270 (Y270F)

Ref Sequence

ENSEMBL: ENSMUSP00000129703 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168230]

AlphaFold

K7N702

Predicted Effect

probably benign
Transcript: ENSMUST00000168230
AA Change: Y270F

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: Y270F

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:ANF_receptor	77	468	2.5e-28	PFAM
Pfam:NCD3G	510	562	1.5e-19	PFAM
Pfam:7tm_3	592	830	1.2e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arid1b	A	G	17: 5,314,315 (GRCm39)	M706V	possibly damaging	Het
Clec1b	T	A	6: 129,374,586 (GRCm39)	D3E	probably damaging	Het
Dqx1	A	G	6: 83,037,309 (GRCm39)	H324R	probably damaging	Het
Ep400	A	G	5: 110,831,702 (GRCm39)		probably benign	Het
Ewsr1	T	C	11: 5,043,689 (GRCm39)	T32A	possibly damaging	Het
Exoc1	C	A	5: 76,693,160 (GRCm39)	H349N	probably benign	Het
Fgg	T	C	3: 82,915,460 (GRCm39)	Y26H	probably benign	Het
Gpld1	T	A	13: 25,163,666 (GRCm39)	Y41*	probably null	Het
Gpr152	A	G	19: 4,193,694 (GRCm39)	M412V	probably benign	Het
Matn2	T	A	15: 34,422,532 (GRCm39)	C540S	probably damaging	Het
Nars1	T	C	18: 64,643,606 (GRCm39)		probably benign	Het
Ncor1	A	G	11: 62,240,229 (GRCm39)	I914T	probably benign	Het
Or1e33	A	G	11: 73,738,207 (GRCm39)	V248A	possibly damaging	Het
Or4k42	A	T	2: 111,320,065 (GRCm39)	F146Y	probably benign	Het
Rev3l	T	C	10: 39,704,212 (GRCm39)	L2086P	probably benign	Het
Snrnp200	T	A	2: 127,071,815 (GRCm39)	I1165N	probably damaging	Het
Spindoc	G	A	19: 7,335,667 (GRCm39)	Q374*	probably null	Het
Thsd1	A	C	8: 22,749,565 (GRCm39)	D751A	probably damaging	Het
Ttll4	G	A	1: 74,718,560 (GRCm39)	R137H	probably benign	Het
Zscan20	A	G	4: 128,480,436 (GRCm39)	I685T	probably damaging	Het

Other mutations in Vmn2r70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00978:Vmn2r70	APN	7	85,213,007 (GRCm39)	missense	probably benign	0.00
IGL01140:Vmn2r70	APN	7	85,214,379 (GRCm39)	nonsense	probably null
IGL01287:Vmn2r70	APN	7	85,218,227 (GRCm39)	nonsense	probably null
IGL01581:Vmn2r70	APN	7	85,213,122 (GRCm39)	splice site	probably null
IGL01632:Vmn2r70	APN	7	85,215,280 (GRCm39)	missense	probably benign	0.00
IGL01725:Vmn2r70	APN	7	85,208,594 (GRCm39)	missense	probably damaging	1.00
IGL02244:Vmn2r70	APN	7	85,214,211 (GRCm39)	missense	probably benign
IGL02313:Vmn2r70	APN	7	85,214,376 (GRCm39)	missense	probably damaging	0.99
IGL02591:Vmn2r70	APN	7	85,214,153 (GRCm39)	missense	probably damaging	0.96
IGL02725:Vmn2r70	APN	7	85,214,553 (GRCm39)	missense	possibly damaging	0.46
IGL02797:Vmn2r70	APN	7	85,208,295 (GRCm39)	missense	probably benign	0.00
R0045:Vmn2r70	UTSW	7	85,215,252 (GRCm39)	missense	probably damaging	1.00
R0729:Vmn2r70	UTSW	7	85,215,112 (GRCm39)	missense	probably benign	0.00
R0967:Vmn2r70	UTSW	7	85,208,827 (GRCm39)	missense	probably damaging	0.99
R1217:Vmn2r70	UTSW	7	85,208,269 (GRCm39)	missense	probably damaging	1.00
R1351:Vmn2r70	UTSW	7	85,214,262 (GRCm39)	missense	probably damaging	1.00
R1387:Vmn2r70	UTSW	7	85,207,969 (GRCm39)	missense	probably benign	0.12
R1483:Vmn2r70	UTSW	7	85,208,375 (GRCm39)	missense	probably benign	0.04
R1796:Vmn2r70	UTSW	7	85,213,011 (GRCm39)	nonsense	probably null
R1809:Vmn2r70	UTSW	7	85,215,130 (GRCm39)	missense	probably benign	0.23
R2154:Vmn2r70	UTSW	7	85,212,923 (GRCm39)	missense	possibly damaging	0.67
R2173:Vmn2r70	UTSW	7	85,214,290 (GRCm39)	missense	probably benign
R2334:Vmn2r70	UTSW	7	85,208,800 (GRCm39)	missense	probably benign	0.05
R2871:Vmn2r70	UTSW	7	85,208,227 (GRCm39)	missense	probably damaging	1.00
R2871:Vmn2r70	UTSW	7	85,208,227 (GRCm39)	missense	probably damaging	1.00
R3975:Vmn2r70	UTSW	7	85,208,540 (GRCm39)	missense	probably benign	0.00
R4525:Vmn2r70	UTSW	7	85,208,787 (GRCm39)	missense	probably damaging	1.00
R4527:Vmn2r70	UTSW	7	85,208,787 (GRCm39)	missense	probably damaging	1.00
R4535:Vmn2r70	UTSW	7	85,214,541 (GRCm39)	missense	probably damaging	1.00
R5181:Vmn2r70	UTSW	7	85,208,387 (GRCm39)	missense	probably damaging	0.99
R5600:Vmn2r70	UTSW	7	85,212,935 (GRCm39)	missense	probably benign	0.07
R5641:Vmn2r70	UTSW	7	85,208,572 (GRCm39)	missense	probably damaging	0.99
R5726:Vmn2r70	UTSW	7	85,208,315 (GRCm39)	missense	probably damaging	1.00
R5943:Vmn2r70	UTSW	7	85,215,199 (GRCm39)	missense	probably benign	0.09
R6166:Vmn2r70	UTSW	7	85,215,189 (GRCm39)	missense	probably benign	0.25
R6272:Vmn2r70	UTSW	7	85,208,194 (GRCm39)	missense	probably damaging	1.00
R6324:Vmn2r70	UTSW	7	85,208,087 (GRCm39)	missense	probably benign	0.01
R6429:Vmn2r70	UTSW	7	85,208,276 (GRCm39)	missense	probably damaging	1.00
R6449:Vmn2r70	UTSW	7	85,214,157 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r70	UTSW	7	85,215,305 (GRCm39)	missense	probably benign
R7000:Vmn2r70	UTSW	7	85,208,819 (GRCm39)	missense	probably damaging	0.99
R7141:Vmn2r70	UTSW	7	85,208,044 (GRCm39)	missense	probably benign
R7153:Vmn2r70	UTSW	7	85,214,262 (GRCm39)	missense	probably damaging	1.00
R7424:Vmn2r70	UTSW	7	85,213,076 (GRCm39)	missense	probably damaging	1.00
R7565:Vmn2r70	UTSW	7	85,214,499 (GRCm39)	missense	probably benign	0.35
R7567:Vmn2r70	UTSW	7	85,214,243 (GRCm39)	missense	probably benign	0.41
R7593:Vmn2r70	UTSW	7	85,215,312 (GRCm39)	nonsense	probably null
R7660:Vmn2r70	UTSW	7	85,218,130 (GRCm39)	missense	probably damaging	0.99
R7806:Vmn2r70	UTSW	7	85,208,401 (GRCm39)	missense	probably benign
R7892:Vmn2r70	UTSW	7	85,208,588 (GRCm39)	missense	possibly damaging	0.58
R7965:Vmn2r70	UTSW	7	85,211,071 (GRCm39)	missense	probably damaging	0.96
R8052:Vmn2r70	UTSW	7	85,212,923 (GRCm39)	missense	probably benign
R8251:Vmn2r70	UTSW	7	85,215,186 (GRCm39)	nonsense	probably null
R8814:Vmn2r70	UTSW	7	85,215,169 (GRCm39)	missense	probably benign	0.00
R8934:Vmn2r70	UTSW	7	85,211,188 (GRCm39)	missense	possibly damaging	0.87
R9225:Vmn2r70	UTSW	7	85,208,242 (GRCm39)	missense	probably damaging	1.00
R9322:Vmn2r70	UTSW	7	85,208,498 (GRCm39)	missense	possibly damaging	0.92
R9430:Vmn2r70	UTSW	7	85,215,240 (GRCm39)	missense	probably benign	0.10
R9477:Vmn2r70	UTSW	7	85,218,244 (GRCm39)	missense	possibly damaging	0.50
Z1088:Vmn2r70	UTSW	7	85,213,968 (GRCm39)	missense	possibly damaging	0.53
Z1176:Vmn2r70	UTSW	7	85,218,253 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16