Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00981:Armh4'

29002

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Armh4

Ensembl Gene

ENSMUSG00000036242

Gene Name

armadillo-like helical domain containing 4

Synonyms

3632451O06Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00981

Quality Score

Status

Chromosome

Chromosomal Location

49919017-50020843 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 50010447 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 420 (L420Q)

Ref Sequence

ENSEMBL: ENSMUSP00000113609 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036972] [ENSMUST00000118129]

AlphaFold

Q8BT18

Predicted Effect

probably damaging
Transcript: ENSMUST00000036972
AA Change: L420Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000036220
Gene: ENSMUSG00000036242
AA Change: L420Q

Domain	Start	End	E-Value	Type
Pfam:DUF4696	48	609	3.8e-224	PFAM
transmembrane domain	714	736	N/A	INTRINSIC
low complexity region	741	753	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000118129
AA Change: L420Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000113609
Gene: ENSMUSG00000036242
AA Change: L420Q

Domain	Start	End	E-Value	Type
coiled coil region	603	644	N/A	INTRINSIC
transmembrane domain	714	736	N/A	INTRINSIC
low complexity region	741	754	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930503L19Rik	G	A	18: 70,586,404 (GRCm39)	Q478*	probably null	Het
Atp7b	T	C	8: 22,517,543 (GRCm39)		probably null	Het
Bcan	T	A	3: 87,905,139 (GRCm39)	I2F	possibly damaging	Het
Boc	A	G	16: 44,312,164 (GRCm39)	S633P	probably damaging	Het
C2cd6	A	G	1: 59,117,104 (GRCm39)	S130P	probably damaging	Het
Cacna1a	T	C	8: 85,275,182 (GRCm39)	F490L	probably damaging	Het
Carm1	T	A	9: 21,498,490 (GRCm39)	D469E	possibly damaging	Het
Cdyl	A	T	13: 36,000,096 (GRCm39)	S126C	probably damaging	Het
Ceacam5	A	T	7: 17,479,458 (GRCm39)	I192F	probably benign	Het
Cyp2b19	C	T	7: 26,462,886 (GRCm39)	T256I	possibly damaging	Het
Dlgap5	C	T	14: 47,635,925 (GRCm39)	E515K	probably damaging	Het
Eif3a	A	T	19: 60,755,049 (GRCm39)	D1044E	unknown	Het
Eif3i	T	A	4: 129,488,862 (GRCm39)	Y125F	probably benign	Het
Gnai1	T	G	5: 18,472,045 (GRCm39)	N346T	probably benign	Het
Kcnd1	C	T	X: 7,702,672 (GRCm39)	T629I	probably benign	Het
Mcc	A	T	18: 44,582,416 (GRCm39)	N578K	probably damaging	Het
Ncoa6	C	T	2: 155,248,099 (GRCm39)	R1735Q	probably damaging	Het
Nlrp4d	A	T	7: 10,116,021 (GRCm39)		noncoding transcript	Het
Nsun5	A	T	5: 135,404,249 (GRCm39)	Q352L	possibly damaging	Het
Or14j6	G	A	17: 38,215,072 (GRCm39)	V212M	probably benign	Het
Or2d2b	C	A	7: 106,705,268 (GRCm39)	E267*	probably null	Het
Or2d2b	T	A	7: 106,705,269 (GRCm39)	K266N	probably benign	Het
Or8g18	A	G	9: 39,148,901 (GRCm39)	V276A	probably benign	Het
Pkdrej	C	T	15: 85,703,857 (GRCm39)	G693D	probably damaging	Het
Rpl10a-ps2	A	T	13: 8,990,566 (GRCm39)		probably benign	Het
Spink1	C	T	18: 43,870,159 (GRCm39)		probably null	Het
Sqle	T	C	15: 59,198,468 (GRCm39)	V464A	probably damaging	Het
Trav6-4	A	T	14: 53,692,153 (GRCm39)	T84S	probably damaging	Het
Trim33	T	A	3: 103,259,311 (GRCm39)		probably benign	Het
Txlng	T	C	X: 161,567,368 (GRCm39)	M319V	probably benign	Het
Wee1	A	T	7: 109,738,876 (GRCm39)	E582D	probably damaging	Het

Other mutations in Armh4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00470:Armh4	APN	14	50,010,460 (GRCm39)	missense	probably damaging	1.00
IGL01447:Armh4	APN	14	50,005,923 (GRCm39)	missense	probably damaging	0.99
IGL01645:Armh4	APN	14	50,011,011 (GRCm39)	missense	probably damaging	1.00
IGL02135:Armh4	APN	14	50,011,386 (GRCm39)	missense	probably damaging	0.99
IGL02154:Armh4	APN	14	50,010,399 (GRCm39)	missense	possibly damaging	0.58
IGL02163:Armh4	APN	14	50,011,614 (GRCm39)	missense	possibly damaging	0.61
IGL03234:Armh4	APN	14	50,005,973 (GRCm39)	missense	probably damaging	1.00
P0014:Armh4	UTSW	14	49,989,116 (GRCm39)	missense	probably damaging	1.00
R0165:Armh4	UTSW	14	50,011,243 (GRCm39)	missense	probably benign
R0240:Armh4	UTSW	14	50,005,859 (GRCm39)	splice site	probably benign
R0553:Armh4	UTSW	14	49,920,143 (GRCm39)	missense	probably damaging	0.99
R0616:Armh4	UTSW	14	50,011,113 (GRCm39)	missense	possibly damaging	0.74
R0635:Armh4	UTSW	14	50,010,600 (GRCm39)	missense	probably benign	0.00
R1423:Armh4	UTSW	14	49,988,896 (GRCm39)	missense	probably damaging	1.00
R1547:Armh4	UTSW	14	50,010,953 (GRCm39)	missense	probably benign	0.01
R1642:Armh4	UTSW	14	50,005,867 (GRCm39)	splice site	probably null
R1657:Armh4	UTSW	14	50,011,017 (GRCm39)	missense	probably damaging	0.99
R1717:Armh4	UTSW	14	49,989,121 (GRCm39)	missense	probably damaging	0.99
R1875:Armh4	UTSW	14	49,919,815 (GRCm39)	missense	probably damaging	1.00
R1900:Armh4	UTSW	14	50,008,040 (GRCm39)	missense	probably damaging	1.00
R1916:Armh4	UTSW	14	50,005,932 (GRCm39)	missense	probably damaging	1.00
R1945:Armh4	UTSW	14	50,005,940 (GRCm39)	missense	probably damaging	1.00
R2102:Armh4	UTSW	14	50,011,459 (GRCm39)	missense	probably damaging	0.98
R2147:Armh4	UTSW	14	49,989,028 (GRCm39)	missense	probably benign	0.31
R2149:Armh4	UTSW	14	49,989,028 (GRCm39)	missense	probably benign	0.31
R3921:Armh4	UTSW	14	50,011,659 (GRCm39)	missense	probably benign	0.13
R4063:Armh4	UTSW	14	50,011,444 (GRCm39)	missense	probably benign	0.02
R4373:Armh4	UTSW	14	50,007,893 (GRCm39)	missense	probably damaging	1.00
R4374:Armh4	UTSW	14	50,007,893 (GRCm39)	missense	probably damaging	1.00
R4377:Armh4	UTSW	14	50,007,893 (GRCm39)	missense	probably damaging	1.00
R4589:Armh4	UTSW	14	50,011,039 (GRCm39)	missense	probably damaging	1.00
R4940:Armh4	UTSW	14	50,010,939 (GRCm39)	missense	probably benign	0.15
R4986:Armh4	UTSW	14	49,989,111 (GRCm39)	missense	probably damaging	0.97
R5047:Armh4	UTSW	14	50,007,895 (GRCm39)	missense	probably damaging	1.00
R5104:Armh4	UTSW	14	50,010,929 (GRCm39)	missense	possibly damaging	0.77
R5682:Armh4	UTSW	14	49,989,043 (GRCm39)	missense	probably damaging	1.00
R6357:Armh4	UTSW	14	50,010,769 (GRCm39)	missense	probably benign	0.10
R6478:Armh4	UTSW	14	50,010,789 (GRCm39)	missense	possibly damaging	0.61
R6673:Armh4	UTSW	14	50,008,049 (GRCm39)	missense	probably benign	0.00
R7035:Armh4	UTSW	14	50,010,507 (GRCm39)	missense	possibly damaging	0.77
R7054:Armh4	UTSW	14	50,011,155 (GRCm39)	missense	probably damaging	1.00
R7458:Armh4	UTSW	14	49,920,196 (GRCm39)	missense	probably damaging	1.00
R7536:Armh4	UTSW	14	50,011,703 (GRCm39)	splice site	probably null
R7944:Armh4	UTSW	14	50,010,670 (GRCm39)	missense	probably benign	0.25
R7945:Armh4	UTSW	14	50,010,670 (GRCm39)	missense	probably benign	0.25
R8049:Armh4	UTSW	14	50,010,993 (GRCm39)	missense	probably damaging	0.97
R8066:Armh4	UTSW	14	50,005,980 (GRCm39)	missense	possibly damaging	0.83
R8519:Armh4	UTSW	14	50,010,693 (GRCm39)	missense	probably damaging	1.00
R8765:Armh4	UTSW	14	49,920,100 (GRCm39)	missense	probably damaging	1.00
R8766:Armh4	UTSW	14	50,011,497 (GRCm39)	missense	probably damaging	1.00
R8833:Armh4	UTSW	14	50,011,318 (GRCm39)	missense	probably benign	0.17
R8936:Armh4	UTSW	14	50,008,024 (GRCm39)	missense	probably damaging	0.98
R9007:Armh4	UTSW	14	50,011,695 (GRCm39)	missense	probably damaging	0.99
R9122:Armh4	UTSW	14	50,011,459 (GRCm39)	missense	possibly damaging	0.64
R9406:Armh4	UTSW	14	50,010,945 (GRCm39)	missense	possibly damaging	0.93
R9741:Armh4	UTSW	14	50,008,081 (GRCm39)	missense	probably benign	0.06
X0026:Armh4	UTSW	14	49,920,193 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-04-17