Incidental Mutation 'IGL02294:Ly6g'
| ID |
290128 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ly6g
|
| Ensembl Gene |
ENSMUSG00000022582 |
| Gene Name |
lymphocyte antigen 6 family member G |
| Synonyms |
Gr-1, Ly-6G, Gr1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
IGL02294
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
75027110-75030977 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 75030413 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 77
(I77N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140173
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023246]
[ENSMUST00000190262]
|
| AlphaFold |
P35461 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000023246
AA Change: I54N
PolyPhen 2
Score 0.868 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000023246
Gene: ENSMUSG00000022582
AA Change: I54N
| Domain | Start | End | E-Value | Type |
|---|
|
LU
|
4 |
95 |
1.64e-33 |
SMART |
|
low complexity region
|
97 |
107 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190262
AA Change: I77N
PolyPhen 2
Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000140173
Gene: ENSMUSG00000022582
AA Change: I77N
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
LU
|
27 |
118 |
8.2e-36 |
SMART |
|
low complexity region
|
120 |
130 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Alpk2 |
A |
G |
18: 65,439,146 (GRCm39) |
V749A |
possibly damaging |
Het |
| Col6a4 |
T |
C |
9: 105,943,931 (GRCm39) |
D1181G |
probably benign |
Het |
| Crb1 |
A |
G |
1: 139,162,520 (GRCm39) |
S1213P |
possibly damaging |
Het |
| D430041D05Rik |
A |
T |
2: 104,085,351 (GRCm39) |
M1066K |
probably benign |
Het |
| Fasn |
G |
T |
11: 120,701,102 (GRCm39) |
T1999N |
probably damaging |
Het |
| Flg2 |
C |
T |
3: 93,111,053 (GRCm39) |
A1027V |
unknown |
Het |
| Gbp5 |
T |
A |
3: 142,209,588 (GRCm39) |
V178E |
probably damaging |
Het |
| Hdac4 |
T |
C |
1: 91,909,929 (GRCm39) |
D445G |
probably benign |
Het |
| Hps3 |
T |
C |
3: 20,068,212 (GRCm39) |
E482G |
probably damaging |
Het |
| Impdh1 |
G |
A |
6: 29,205,201 (GRCm39) |
A200V |
probably benign |
Het |
| Kdm2b |
T |
C |
5: 123,099,537 (GRCm39) |
Y134C |
probably damaging |
Het |
| Oprk1 |
T |
G |
1: 5,672,610 (GRCm39) |
M249R |
probably damaging |
Het |
| Or5ac21 |
T |
C |
16: 59,123,975 (GRCm39) |
L153P |
probably damaging |
Het |
| Or5h17 |
T |
C |
16: 58,820,428 (GRCm39) |
C127R |
probably damaging |
Het |
| Otud4 |
A |
G |
8: 80,391,606 (GRCm39) |
|
probably benign |
Het |
| Slc16a4 |
T |
C |
3: 107,208,384 (GRCm39) |
I298T |
probably benign |
Het |
| Sox21 |
A |
G |
14: 118,472,950 (GRCm39) |
M33T |
probably benign |
Het |
| Speer4a1 |
T |
A |
5: 26,243,240 (GRCm39) |
T82S |
probably benign |
Het |
| Stard13 |
T |
C |
5: 150,986,580 (GRCm39) |
D310G |
probably benign |
Het |
| Trpm6 |
C |
A |
19: 18,831,427 (GRCm39) |
Q1431K |
probably benign |
Het |
| Ufl1 |
T |
A |
4: 25,259,281 (GRCm39) |
K446* |
probably null |
Het |
| Vmn2r19 |
A |
G |
6: 123,306,937 (GRCm39) |
T482A |
probably benign |
Het |
|
| Other mutations in Ly6g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01403:Ly6g
|
APN |
15 |
75,030,497 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1389:Ly6g
|
UTSW |
15 |
75,028,615 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1450:Ly6g
|
UTSW |
15 |
75,030,482 (GRCm39) |
missense |
probably benign |
0.16 |
|
R4179:Ly6g
|
UTSW |
15 |
75,027,567 (GRCm39) |
splice site |
probably null |
|
|
R5746:Ly6g
|
UTSW |
15 |
75,028,596 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6514:Ly6g
|
UTSW |
15 |
75,028,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6777:Ly6g
|
UTSW |
15 |
75,030,431 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6967:Ly6g
|
UTSW |
15 |
75,030,398 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7574:Ly6g
|
UTSW |
15 |
75,030,413 (GRCm39) |
missense |
probably benign |
0.39 |
|
R8744:Ly6g
|
UTSW |
15 |
75,027,518 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9261:Ly6g
|
UTSW |
15 |
75,030,529 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9746:Ly6g
|
UTSW |
15 |
75,030,458 (GRCm39) |
missense |
probably benign |
0.13 |
|
| Posted On |
2015-04-16 |
Incidental Mutation