Incidental Mutation 'IGL02297:Gm12888'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm12888
Ensembl Gene ENSMUSG00000073764
Gene Namepredicted gene 12888
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.244) question?
Stock #IGL02297
Quality Score
Chromosomal Location121316316-121324917 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 121324799 bp
Amino Acid Change Glutamic Acid to Glycine at position 32 (E32G)
Ref Sequence ENSEMBL: ENSMUSP00000095515 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097905]
Predicted Effect probably damaging
Transcript: ENSMUST00000097905
AA Change: E32G

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000095515
Gene: ENSMUSG00000073764
AA Change: E32G

signal peptide 1 21 N/A INTRINSIC
Pfam:Palm_thioest 32 119 2e-9 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aifm2 C T 10: 61,735,548 A287V possibly damaging Het
Aqr A G 2: 114,150,481 I273T probably benign Het
Arid3c T C 4: 41,730,021 E58G possibly damaging Het
Col5a3 G T 9: 20,772,154 T1574K unknown Het
Dbh T C 2: 27,177,736 V457A probably benign Het
Gnaq A G 19: 16,378,251 D277G probably damaging Het
Il20 G A 1: 130,908,408 H133Y probably damaging Het
Itpr1 T A 6: 108,339,517 F58L possibly damaging Het
Lynx1 G T 15: 74,751,642 Q19K probably benign Het
Lyst G T 13: 13,638,092 E1030* probably null Het
Matn1 T A 4: 130,952,264 probably benign Het
Nav2 A T 7: 49,594,229 N2068I probably damaging Het
Olfr1469 C T 19: 13,411,475 T302I probably benign Het
Olfr948 T C 9: 39,318,703 I304V possibly damaging Het
Slc25a23 G T 17: 57,053,324 Q273K probably benign Het
Slco4a1 T G 2: 180,464,489 C155G probably benign Het
Txnip T C 3: 96,558,357 V41A probably damaging Het
Wnt16 C A 6: 22,297,991 Y285* probably null Het
Other mutations in Gm12888
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00588:Gm12888 APN 4 121319445 missense possibly damaging 0.93
IGL01113:Gm12888 APN 4 121318324 missense probably damaging 0.99
R2064:Gm12888 UTSW 4 121324872 missense unknown
R2096:Gm12888 UTSW 4 121319458 missense probably benign 0.07
R2447:Gm12888 UTSW 4 121318350 missense possibly damaging 0.64
R5800:Gm12888 UTSW 4 121319428 missense probably damaging 0.99
R6406:Gm12888 UTSW 4 121319457 missense possibly damaging 0.93
Posted On2015-04-16