Incidental Mutation 'IGL02291:Tas2r126'
| ID |
290314 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Tas2r126
|
| Ensembl Gene |
ENSMUSG00000048284 |
| Gene Name |
taste receptor, type 2, member 126 |
| Synonyms |
mGR26, T2R26, mt2r35, T2R12, Tas2r26 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.058)
|
| Stock # |
IGL02291
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
42411469-42412395 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 42412221 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Isoleucine
at position 251
(M251I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056581
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059534]
|
| AlphaFold |
P59532 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059534
AA Change: M251I
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000056581
Gene: ENSMUSG00000048284
AA Change: M251I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
303 |
2.5e-97 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgap10 |
T |
A |
8: 78,109,344 (GRCm39) |
|
probably benign |
Het |
| Cfap161 |
C |
T |
7: 83,440,847 (GRCm39) |
G135D |
probably benign |
Het |
| Cpne1 |
A |
G |
2: 155,920,340 (GRCm39) |
V179A |
probably damaging |
Het |
| Cpsf1 |
A |
T |
15: 76,487,021 (GRCm39) |
I219N |
probably damaging |
Het |
| Creb3l4 |
T |
G |
3: 90,149,290 (GRCm39) |
R139S |
probably benign |
Het |
| Fer1l4 |
T |
C |
2: 155,861,458 (GRCm39) |
K1929E |
probably damaging |
Het |
| Gm5431 |
A |
G |
11: 48,779,791 (GRCm39) |
L655P |
probably damaging |
Het |
| Igsf3 |
T |
G |
3: 101,346,845 (GRCm39) |
H613Q |
probably damaging |
Het |
| Kcnab1 |
T |
C |
3: 65,264,503 (GRCm39) |
Y251H |
possibly damaging |
Het |
| Kmt2d |
T |
C |
15: 98,763,373 (GRCm39) |
|
probably benign |
Het |
| Krt17 |
A |
T |
11: 100,147,319 (GRCm39) |
V404E |
probably benign |
Het |
| Lipo2 |
A |
G |
19: 33,723,192 (GRCm39) |
I199T |
possibly damaging |
Het |
| Mks1 |
T |
A |
11: 87,750,493 (GRCm39) |
|
probably benign |
Het |
| Nlrp1a |
A |
T |
11: 71,013,415 (GRCm39) |
|
probably null |
Het |
| Nup210 |
T |
C |
6: 91,078,250 (GRCm39) |
D100G |
probably damaging |
Het |
| Or13a21 |
A |
T |
7: 139,999,200 (GRCm39) |
L162Q |
probably damaging |
Het |
| Or1o11 |
G |
A |
17: 37,757,176 (GRCm39) |
V255I |
possibly damaging |
Het |
| Or2y1g |
T |
A |
11: 49,171,812 (GRCm39) |
I279N |
probably damaging |
Het |
| Or7h8 |
T |
C |
9: 20,124,098 (GRCm39) |
I151T |
probably benign |
Het |
| Psmd5 |
A |
G |
2: 34,747,811 (GRCm39) |
V282A |
probably benign |
Het |
| Rasal3 |
A |
T |
17: 32,612,711 (GRCm39) |
|
probably benign |
Het |
| Rnf10 |
T |
C |
5: 115,398,255 (GRCm39) |
N93D |
probably damaging |
Het |
| Semp2l2a |
T |
A |
8: 13,887,704 (GRCm39) |
N129I |
probably benign |
Het |
| Slc7a9 |
G |
A |
7: 35,156,439 (GRCm39) |
G294R |
probably damaging |
Het |
| Taf7 |
C |
T |
18: 37,776,415 (GRCm39) |
G51R |
possibly damaging |
Het |
| Trim33 |
T |
C |
3: 103,234,181 (GRCm39) |
F473S |
probably damaging |
Het |
| Vmn1r127 |
A |
G |
7: 21,052,999 (GRCm39) |
L263P |
possibly damaging |
Het |
| Vmn1r234 |
G |
A |
17: 21,449,193 (GRCm39) |
V36I |
probably benign |
Het |
| Vmn2r84 |
T |
A |
10: 130,226,617 (GRCm39) |
H407L |
probably damaging |
Het |
|
| Other mutations in Tas2r126 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00915:Tas2r126
|
APN |
6 |
42,412,283 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01327:Tas2r126
|
APN |
6 |
42,411,684 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL01690:Tas2r126
|
APN |
6 |
42,412,241 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02153:Tas2r126
|
APN |
6 |
42,411,598 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03365:Tas2r126
|
APN |
6 |
42,412,391 (GRCm39) |
missense |
probably benign |
0.36 |
|
R0091:Tas2r126
|
UTSW |
6 |
42,412,036 (GRCm39) |
missense |
probably benign |
|
|
R0486:Tas2r126
|
UTSW |
6 |
42,412,225 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0611:Tas2r126
|
UTSW |
6 |
42,412,025 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1527:Tas2r126
|
UTSW |
6 |
42,412,070 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1529:Tas2r126
|
UTSW |
6 |
42,411,502 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1883:Tas2r126
|
UTSW |
6 |
42,411,961 (GRCm39) |
missense |
probably benign |
|
|
R1884:Tas2r126
|
UTSW |
6 |
42,411,961 (GRCm39) |
missense |
probably benign |
|
|
R2039:Tas2r126
|
UTSW |
6 |
42,411,557 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4863:Tas2r126
|
UTSW |
6 |
42,412,324 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5975:Tas2r126
|
UTSW |
6 |
42,411,934 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7127:Tas2r126
|
UTSW |
6 |
42,411,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7351:Tas2r126
|
UTSW |
6 |
42,412,240 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7714:Tas2r126
|
UTSW |
6 |
42,412,031 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9154:Tas2r126
|
UTSW |
6 |
42,412,174 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9336:Tas2r126
|
UTSW |
6 |
42,411,877 (GRCm39) |
missense |
probably benign |
0.45 |
|
R9516:Tas2r126
|
UTSW |
6 |
42,412,307 (GRCm39) |
missense |
probably null |
0.98 |
|
R9722:Tas2r126
|
UTSW |
6 |
42,412,082 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
| Posted On |
2015-04-16 |
Incidental Mutation