Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02291:Vmn1r127'

290317

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r127

Ensembl Gene

ENSMUSG00000093890

Gene Name

vomeronasal 1 receptor 127

Synonyms

Gm6239

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02291

Quality Score

Status

Chromosome

Chromosomal Location

21052869-21053786 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 21052999 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 263 (L263P)

Ref Sequence

ENSEMBL: ENSMUSP00000100834 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105199]

AlphaFold

K7N6J5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000105199
AA Change: L263P

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000100834
Gene: ENSMUSG00000093890
AA Change: L263P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	3.2e-17	PFAM
Pfam:7tm_1	40	288	3.1e-9	PFAM
Pfam:V1R	41	296	1.7e-15	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap10	T	A	8: 78,109,344 (GRCm39)		probably benign	Het
Cfap161	C	T	7: 83,440,847 (GRCm39)	G135D	probably benign	Het
Cpne1	A	G	2: 155,920,340 (GRCm39)	V179A	probably damaging	Het
Cpsf1	A	T	15: 76,487,021 (GRCm39)	I219N	probably damaging	Het
Creb3l4	T	G	3: 90,149,290 (GRCm39)	R139S	probably benign	Het
Fer1l4	T	C	2: 155,861,458 (GRCm39)	K1929E	probably damaging	Het
Gm5431	A	G	11: 48,779,791 (GRCm39)	L655P	probably damaging	Het
Igsf3	T	G	3: 101,346,845 (GRCm39)	H613Q	probably damaging	Het
Kcnab1	T	C	3: 65,264,503 (GRCm39)	Y251H	possibly damaging	Het
Kmt2d	T	C	15: 98,763,373 (GRCm39)		probably benign	Het
Krt17	A	T	11: 100,147,319 (GRCm39)	V404E	probably benign	Het
Lipo2	A	G	19: 33,723,192 (GRCm39)	I199T	possibly damaging	Het
Mks1	T	A	11: 87,750,493 (GRCm39)		probably benign	Het
Nlrp1a	A	T	11: 71,013,415 (GRCm39)		probably null	Het
Nup210	T	C	6: 91,078,250 (GRCm39)	D100G	probably damaging	Het
Or13a21	A	T	7: 139,999,200 (GRCm39)	L162Q	probably damaging	Het
Or1o11	G	A	17: 37,757,176 (GRCm39)	V255I	possibly damaging	Het
Or2y1g	T	A	11: 49,171,812 (GRCm39)	I279N	probably damaging	Het
Or7h8	T	C	9: 20,124,098 (GRCm39)	I151T	probably benign	Het
Psmd5	A	G	2: 34,747,811 (GRCm39)	V282A	probably benign	Het
Rasal3	A	T	17: 32,612,711 (GRCm39)		probably benign	Het
Rnf10	T	C	5: 115,398,255 (GRCm39)	N93D	probably damaging	Het
Semp2l2a	T	A	8: 13,887,704 (GRCm39)	N129I	probably benign	Het
Slc7a9	G	A	7: 35,156,439 (GRCm39)	G294R	probably damaging	Het
Taf7	C	T	18: 37,776,415 (GRCm39)	G51R	possibly damaging	Het
Tas2r126	G	A	6: 42,412,221 (GRCm39)	M251I	probably benign	Het
Trim33	T	C	3: 103,234,181 (GRCm39)	F473S	probably damaging	Het
Vmn1r234	G	A	17: 21,449,193 (GRCm39)	V36I	probably benign	Het
Vmn2r84	T	A	10: 130,226,617 (GRCm39)	H407L	probably damaging	Het

Other mutations in Vmn1r127

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R4994:Vmn1r127	UTSW	7	21,052,943 (GRCm39)	missense	probably damaging	1.00
R6264:Vmn1r127	UTSW	7	21,052,930 (GRCm39)	missense	probably benign	0.06
R7301:Vmn1r127	UTSW	7	21,052,978 (GRCm39)	missense	probably benign	0.36
R9287:Vmn1r127	UTSW	7	21,052,927 (GRCm39)	missense	possibly damaging	0.95

Posted On

2015-04-16