Incidental Mutation 'IGL02291:Cfap161'
ID290321
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cfap161
Ensembl Gene ENSMUSG00000011154
Gene Namecilia and flagella associated protein 161
Synonyms1700026D08Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL02291
Quality Score
Status
Chromosome7
Chromosomal Location83774101-83794880 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 83791639 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Aspartic acid at position 135 (G135D)
Ref Sequence ENSEMBL: ENSMUSP00000115281 (fasta)
Predicted Effect probably benign
Transcript: ENSMUST00000011298
AA Change: G160D

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000119134
AA Change: G160D

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Predicted Effect probably benign
Transcript: ENSMUST00000149671
AA Change: G135D

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AF366264 T A 8: 13,837,704 N129I probably benign Het
Arhgap10 T A 8: 77,382,715 probably benign Het
Cpne1 A G 2: 156,078,420 V179A probably damaging Het
Cpsf1 A T 15: 76,602,821 I219N probably damaging Het
Creb3l4 T G 3: 90,241,983 R139S probably benign Het
Fer1l4 T C 2: 156,019,538 K1929E probably damaging Het
Gm5431 A G 11: 48,888,964 L655P probably damaging Het
Igsf3 T G 3: 101,439,529 H613Q probably damaging Het
Kcnab1 T C 3: 65,357,082 Y251H possibly damaging Het
Kmt2d T C 15: 98,865,492 probably benign Het
Krt17 A T 11: 100,256,493 V404E probably benign Het
Lipo2 A G 19: 33,745,792 I199T possibly damaging Het
Mks1 T A 11: 87,859,667 probably benign Het
Nlrp1a A T 11: 71,122,589 probably null Het
Nup210 T C 6: 91,101,268 D100G probably damaging Het
Olfr108 G A 17: 37,446,285 V255I possibly damaging Het
Olfr1393 T A 11: 49,280,985 I279N probably damaging Het
Olfr532 A T 7: 140,419,287 L162Q probably damaging Het
Olfr871 T C 9: 20,212,802 I151T probably benign Het
Psmd5 A G 2: 34,857,799 V282A probably benign Het
Rasal3 A T 17: 32,393,737 probably benign Het
Rnf10 T C 5: 115,260,196 N93D probably damaging Het
Slc7a9 G A 7: 35,457,014 G294R probably damaging Het
Taf7 C T 18: 37,643,362 G51R possibly damaging Het
Tas2r126 G A 6: 42,435,287 M251I probably benign Het
Trim33 T C 3: 103,326,865 F473S probably damaging Het
Vmn1r127 A G 7: 21,319,074 L263P possibly damaging Het
Vmn1r234 G A 17: 21,228,931 V36I probably benign Het
Vmn2r84 T A 10: 130,390,748 H407L probably damaging Het
Other mutations in Cfap161
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01827:Cfap161 APN 7 83793440 missense possibly damaging 0.86
IGL01999:Cfap161 APN 7 83791691 missense probably damaging 1.00
IGL02444:Cfap161 APN 7 83776145 missense probably damaging 1.00
R0492:Cfap161 UTSW 7 83794037 missense possibly damaging 0.90
R0652:Cfap161 UTSW 7 83793276 missense probably null 0.01
R1599:Cfap161 UTSW 7 83776079 missense possibly damaging 0.84
R1828:Cfap161 UTSW 7 83791724 critical splice acceptor site probably null
R2117:Cfap161 UTSW 7 83775976 missense possibly damaging 0.63
R2262:Cfap161 UTSW 7 83793372 missense probably benign 0.37
R3618:Cfap161 UTSW 7 83780182 nonsense probably null
R4015:Cfap161 UTSW 7 83780271 missense probably benign 0.01
R5821:Cfap161 UTSW 7 83775980 missense probably benign 0.38
R6477:Cfap161 UTSW 7 83794022 nonsense probably null
R6478:Cfap161 UTSW 7 83793276 missense probably benign 0.00
R7108:Cfap161 UTSW 7 83793310 missense possibly damaging 0.60
R7203:Cfap161 UTSW 7 83776050 missense probably damaging 0.97
Posted On2015-04-16