Incidental Mutation 'IGL02357:Lipo2'
ID 290569
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lipo2
Ensembl Gene ENSMUSG00000087303
Gene Name lipase, member O2
Synonyms Gm8981
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL02357
Quality Score
Status
Chromosome 19
Chromosomal Location 33697070-33728759 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 33708348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 222 (L222P)
Ref Sequence ENSEMBL: ENSMUSP00000118907 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025694] [ENSMUST00000147153]
AlphaFold D3YY49
Predicted Effect probably benign
Transcript: ENSMUST00000025694
SMART Domains Protein: ENSMUSP00000025694
Gene: ENSMUSG00000024766

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 4.2e-24 PFAM
Pfam:Abhydrolase_1 76 213 7.3e-16 PFAM
Pfam:Abhydrolase_5 76 370 4.8e-12 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000147153
AA Change: L222P

PolyPhen 2 Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000118907
Gene: ENSMUSG00000087303
AA Change: L222P

DomainStartEndE-ValueType
Pfam:Abhydro_lipase 33 95 4.4e-24 PFAM
Pfam:Abhydrolase_1 76 213 1.7e-15 PFAM
Pfam:Abhydrolase_5 76 370 1.5e-11 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd8 A G 8: 71,914,121 (GRCm39) V169A probably benign Het
Adamts16 T A 13: 70,886,704 (GRCm39) T1029S probably benign Het
Adgrv1 C A 13: 81,418,974 (GRCm39) C6007F probably benign Het
Ak8 A T 2: 28,590,225 (GRCm39) H8L probably benign Het
Apol7b A G 15: 77,307,832 (GRCm39) V221A probably benign Het
BC005624 G A 2: 30,863,779 (GRCm39) P235S probably benign Het
Casp9 C A 4: 141,532,783 (GRCm39) D226E probably benign Het
Cd96 A G 16: 45,890,139 (GRCm39) probably benign Het
Celf1 A T 2: 90,828,933 (GRCm39) K27I probably damaging Het
Cfap65 A T 1: 74,967,507 (GRCm39) C190* probably null Het
Cib2 A T 9: 54,457,170 (GRCm39) H31Q probably damaging Het
Cyp3a59 T C 5: 146,016,152 (GRCm39) L3P probably damaging Het
Dnajc13 T C 9: 104,039,558 (GRCm39) M2104V possibly damaging Het
Emb A G 13: 117,386,007 (GRCm39) probably benign Het
Fbn2 G T 18: 58,237,067 (GRCm39) N645K possibly damaging Het
Fes T C 7: 80,033,578 (GRCm39) probably null Het
Flnc A T 6: 29,438,492 (GRCm39) K129* probably null Het
Gckr C A 5: 31,465,134 (GRCm39) H368N possibly damaging Het
Gm5145 A T 17: 20,790,702 (GRCm39) I27F probably damaging Het
Hecw1 A G 13: 14,422,923 (GRCm39) probably null Het
Hook2 C T 8: 85,721,614 (GRCm39) Q291* probably null Het
Jakmip2 T C 18: 43,680,192 (GRCm39) T722A possibly damaging Het
Kcnt2 A G 1: 140,279,007 (GRCm39) I53V probably benign Het
Mrc2 A G 11: 105,216,547 (GRCm39) D112G probably damaging Het
Mroh2b A G 15: 4,941,482 (GRCm39) N338S probably benign Het
Mrpl23 T A 7: 142,089,802 (GRCm39) probably benign Het
Myo18a A G 11: 77,741,073 (GRCm39) N1442S probably benign Het
Ngdn T A 14: 55,259,393 (GRCm39) V179E probably damaging Het
Nxn A G 11: 76,165,480 (GRCm39) probably benign Het
Or10am5 T A 7: 6,518,225 (GRCm39) M68L probably damaging Het
Or2b7 A G 13: 21,739,772 (GRCm39) L140P probably damaging Het
Osmr A T 15: 6,858,144 (GRCm39) N441K probably benign Het
Plcb3 A C 19: 6,935,546 (GRCm39) L789R probably damaging Het
Plek C T 11: 16,931,846 (GRCm39) R335H probably damaging Het
Pmp22 G T 11: 63,049,134 (GRCm39) V126F probably benign Het
Prom1 A G 5: 44,186,946 (GRCm39) probably benign Het
Prss1 C A 6: 41,440,139 (GRCm39) Q159K probably damaging Het
Psd3 G T 8: 68,416,521 (GRCm39) H459N probably benign Het
Rusc2 T G 4: 43,425,351 (GRCm39) V1152G possibly damaging Het
Slc16a4 A G 3: 107,210,415 (GRCm39) I362V probably benign Het
Slc22a22 A G 15: 57,110,844 (GRCm39) V461A probably benign Het
Slc35e4 C T 11: 3,862,640 (GRCm39) R183Q probably benign Het
Spen T C 4: 141,204,890 (GRCm39) T1246A unknown Het
Syt16 T C 12: 74,313,616 (GRCm39) V514A probably benign Het
Tdpoz2 A G 3: 93,559,735 (GRCm39) V79A possibly damaging Het
Tpgs1 A G 10: 79,511,593 (GRCm39) D245G probably benign Het
Ttn A G 2: 76,539,963 (GRCm39) V34341A probably benign Het
Vxn T C 1: 9,683,544 (GRCm39) I44T possibly damaging Het
Wwox T C 8: 115,438,882 (GRCm39) V316A possibly damaging Het
Other mutations in Lipo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01564:Lipo2 APN 19 33,698,424 (GRCm39) missense probably benign 0.03
IGL01780:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL01868:Lipo2 APN 19 33,708,238 (GRCm39) missense probably benign 0.00
IGL02291:Lipo2 APN 19 33,723,192 (GRCm39) missense possibly damaging 0.80
IGL02350:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL02560:Lipo2 APN 19 33,708,348 (GRCm39) missense possibly damaging 0.82
IGL03354:Lipo2 APN 19 33,708,270 (GRCm39) missense probably benign 0.09
R0183:Lipo2 UTSW 19 33,726,951 (GRCm39) splice site probably null
R0529:Lipo2 UTSW 19 33,724,335 (GRCm39) missense probably benign 0.05
R0576:Lipo2 UTSW 19 33,726,824 (GRCm39) missense probably benign 0.02
R0579:Lipo2 UTSW 19 33,724,298 (GRCm39) missense probably damaging 0.99
R0594:Lipo2 UTSW 19 33,724,302 (GRCm39) missense possibly damaging 0.95
R0621:Lipo2 UTSW 19 33,708,339 (GRCm39) missense probably damaging 1.00
R1019:Lipo2 UTSW 19 33,708,257 (GRCm39) nonsense probably null
R2190:Lipo2 UTSW 19 33,725,969 (GRCm39) missense probably damaging 1.00
R2413:Lipo2 UTSW 19 33,728,657 (GRCm39) missense probably damaging 0.98
R4066:Lipo2 UTSW 19 33,698,259 (GRCm39) missense probably benign 0.01
R4258:Lipo2 UTSW 19 33,708,328 (GRCm39) missense possibly damaging 0.88
R4365:Lipo2 UTSW 19 33,699,108 (GRCm39) missense probably damaging 1.00
R4491:Lipo2 UTSW 19 33,699,100 (GRCm39) missense probably damaging 0.99
R4640:Lipo2 UTSW 19 33,698,237 (GRCm39) missense probably benign 0.04
R4822:Lipo2 UTSW 19 33,723,151 (GRCm39) missense probably benign 0.01
R4872:Lipo2 UTSW 19 33,726,914 (GRCm39) missense probably benign 0.00
R5004:Lipo2 UTSW 19 33,699,076 (GRCm39) critical splice donor site probably null
R5112:Lipo2 UTSW 19 33,725,865 (GRCm39) missense probably benign 0.00
R5440:Lipo2 UTSW 19 33,698,258 (GRCm39) missense probably benign 0.39
R5737:Lipo2 UTSW 19 33,699,096 (GRCm39) missense probably damaging 1.00
R6209:Lipo2 UTSW 19 33,726,852 (GRCm39) missense probably damaging 1.00
R6868:Lipo2 UTSW 19 33,725,862 (GRCm39) missense possibly damaging 0.86
R6893:Lipo2 UTSW 19 33,698,407 (GRCm39) nonsense probably null
R7176:Lipo2 UTSW 19 33,723,207 (GRCm39) missense possibly damaging 0.71
R7853:Lipo2 UTSW 19 33,737,344 (GRCm39) start gained probably benign
R8092:Lipo2 UTSW 19 33,726,880 (GRCm39) missense probably benign 0.00
R8101:Lipo2 UTSW 19 33,698,394 (GRCm39) missense possibly damaging 0.79
R8464:Lipo2 UTSW 19 33,726,023 (GRCm39) missense probably benign 0.02
R8958:Lipo2 UTSW 19 33,698,361 (GRCm39) nonsense probably null
R8968:Lipo2 UTSW 19 33,726,917 (GRCm39) missense probably damaging 1.00
R9752:Lipo2 UTSW 19 33,723,221 (GRCm39) missense possibly damaging 0.78
X0052:Lipo2 UTSW 19 33,698,345 (GRCm39) missense probably damaging 1.00
Z1088:Lipo2 UTSW 19 33,699,085 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16