Incidental Mutation 'IGL02363:Comt'
ID |
290631 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Comt
|
Ensembl Gene |
ENSMUSG00000000326 |
Gene Name |
catechol-O-methyltransferase |
Synonyms |
D16Wsu103e, Comt1, D330014B15Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL02363
|
Quality Score |
|
Status
|
|
Chromosome |
16 |
Chromosomal Location |
18225636-18245602 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 18229881 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 153
(D153G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000121810
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000000335]
[ENSMUST00000090103]
[ENSMUST00000115609]
[ENSMUST00000115610]
[ENSMUST00000115612]
[ENSMUST00000115613]
[ENSMUST00000115614]
[ENSMUST00000165430]
[ENSMUST00000147720]
[ENSMUST00000150253]
[ENSMUST00000232025]
|
AlphaFold |
O88587 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000000335
AA Change: D153G
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000000335 Gene: ENSMUSG00000000326 AA Change: D153G
Domain | Start | End | E-Value | Type |
transmembrane domain
|
2 |
24 |
N/A |
INTRINSIC |
Pfam:Methyltransf_3
|
63 |
224 |
3.5e-24 |
PFAM |
Pfam:Methyltransf_26
|
102 |
224 |
3.3e-9 |
PFAM |
Pfam:Methyltransf_24
|
106 |
214 |
1.2e-13 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000090103
|
SMART Domains |
Protein: ENSMUSP00000087562 Gene: ENSMUSG00000000325
Domain | Start | End | E-Value | Type |
coiled coil region
|
11 |
46 |
N/A |
INTRINSIC |
low complexity region
|
89 |
99 |
N/A |
INTRINSIC |
low complexity region
|
117 |
138 |
N/A |
INTRINSIC |
low complexity region
|
141 |
157 |
N/A |
INTRINSIC |
low complexity region
|
208 |
227 |
N/A |
INTRINSIC |
ARM
|
391 |
431 |
4.48e-7 |
SMART |
ARM
|
434 |
475 |
3.31e-10 |
SMART |
Blast:ARM
|
476 |
533 |
2e-20 |
BLAST |
ARM
|
536 |
582 |
2.1e1 |
SMART |
ARM
|
652 |
693 |
9.55e1 |
SMART |
ARM
|
699 |
739 |
4.05e-5 |
SMART |
ARM
|
790 |
832 |
3.03e0 |
SMART |
low complexity region
|
927 |
945 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115609
AA Change: D153G
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000111272 Gene: ENSMUSG00000000326 AA Change: D153G
Domain | Start | End | E-Value | Type |
transmembrane domain
|
2 |
24 |
N/A |
INTRINSIC |
Pfam:Methyltransf_3
|
63 |
224 |
3.5e-24 |
PFAM |
Pfam:Methyltransf_26
|
102 |
224 |
3.3e-9 |
PFAM |
Pfam:Methyltransf_24
|
106 |
214 |
1.2e-13 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115610
|
SMART Domains |
Protein: ENSMUSP00000111273 Gene: ENSMUSG00000000325
Domain | Start | End | E-Value | Type |
low complexity region
|
25 |
35 |
N/A |
INTRINSIC |
low complexity region
|
53 |
74 |
N/A |
INTRINSIC |
low complexity region
|
77 |
93 |
N/A |
INTRINSIC |
low complexity region
|
144 |
163 |
N/A |
INTRINSIC |
ARM
|
327 |
367 |
4.48e-7 |
SMART |
ARM
|
370 |
411 |
3.31e-10 |
SMART |
Blast:ARM
|
412 |
469 |
1e-20 |
BLAST |
ARM
|
472 |
518 |
2.1e1 |
SMART |
low complexity region
|
555 |
563 |
N/A |
INTRINSIC |
ARM
|
582 |
623 |
9.55e1 |
SMART |
ARM
|
629 |
669 |
4.05e-5 |
SMART |
ARM
|
720 |
762 |
3.03e0 |
SMART |
low complexity region
|
857 |
875 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115612
|
SMART Domains |
Protein: ENSMUSP00000111275 Gene: ENSMUSG00000000325
Domain | Start | End | E-Value | Type |
coiled coil region
|
11 |
46 |
N/A |
INTRINSIC |
low complexity region
|
89 |
99 |
N/A |
INTRINSIC |
low complexity region
|
117 |
138 |
N/A |
INTRINSIC |
low complexity region
|
141 |
157 |
N/A |
INTRINSIC |
low complexity region
|
208 |
227 |
N/A |
INTRINSIC |
ARM
|
391 |
431 |
4.48e-7 |
SMART |
ARM
|
434 |
475 |
3.31e-10 |
SMART |
Blast:ARM
|
476 |
533 |
2e-20 |
BLAST |
ARM
|
536 |
582 |
2.1e1 |
SMART |
low complexity region
|
619 |
627 |
N/A |
INTRINSIC |
ARM
|
646 |
687 |
9.55e1 |
SMART |
ARM
|
693 |
733 |
4.05e-5 |
SMART |
ARM
|
784 |
826 |
3.03e0 |
SMART |
low complexity region
|
921 |
939 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115613
|
SMART Domains |
Protein: ENSMUSP00000111276 Gene: ENSMUSG00000000325
Domain | Start | End | E-Value | Type |
coiled coil region
|
11 |
46 |
N/A |
INTRINSIC |
low complexity region
|
89 |
99 |
N/A |
INTRINSIC |
low complexity region
|
117 |
138 |
N/A |
INTRINSIC |
low complexity region
|
141 |
157 |
N/A |
INTRINSIC |
low complexity region
|
208 |
227 |
N/A |
INTRINSIC |
ARM
|
391 |
431 |
4.48e-7 |
SMART |
ARM
|
434 |
475 |
3.31e-10 |
SMART |
Blast:ARM
|
476 |
533 |
2e-20 |
BLAST |
ARM
|
536 |
582 |
2.1e1 |
SMART |
ARM
|
652 |
693 |
9.55e1 |
SMART |
ARM
|
699 |
739 |
4.05e-5 |
SMART |
ARM
|
790 |
832 |
3.03e0 |
SMART |
low complexity region
|
927 |
945 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115614
|
SMART Domains |
Protein: ENSMUSP00000111278 Gene: ENSMUSG00000000325
Domain | Start | End | E-Value | Type |
coiled coil region
|
11 |
46 |
N/A |
INTRINSIC |
low complexity region
|
89 |
99 |
N/A |
INTRINSIC |
low complexity region
|
117 |
138 |
N/A |
INTRINSIC |
low complexity region
|
141 |
157 |
N/A |
INTRINSIC |
low complexity region
|
208 |
227 |
N/A |
INTRINSIC |
ARM
|
391 |
431 |
4.48e-7 |
SMART |
ARM
|
434 |
475 |
3.31e-10 |
SMART |
Blast:ARM
|
476 |
533 |
2e-20 |
BLAST |
ARM
|
536 |
582 |
2.1e1 |
SMART |
low complexity region
|
619 |
627 |
N/A |
INTRINSIC |
ARM
|
646 |
687 |
9.55e1 |
SMART |
ARM
|
693 |
733 |
4.05e-5 |
SMART |
ARM
|
784 |
826 |
3.03e0 |
SMART |
low complexity region
|
921 |
939 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000165430
AA Change: D153G
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
SMART Domains |
Protein: ENSMUSP00000130077 Gene: ENSMUSG00000000326 AA Change: D153G
Domain | Start | End | E-Value | Type |
transmembrane domain
|
2 |
24 |
N/A |
INTRINSIC |
Pfam:Methyltransf_3
|
57 |
221 |
1.1e-22 |
PFAM |
Pfam:Methyltransf_24
|
106 |
214 |
6.2e-14 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000147720
AA Change: D153G
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000121810 Gene: ENSMUSG00000000326 AA Change: D153G
Domain | Start | End | E-Value | Type |
transmembrane domain
|
2 |
24 |
N/A |
INTRINSIC |
Pfam:Methyltransf_3
|
62 |
171 |
4.1e-18 |
PFAM |
Pfam:Methyltransf_24
|
106 |
171 |
4.4e-9 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000150253
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000232025
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] PHENOTYPE: Mice homozygous for disruption of this gene are viable, fertile, and show no gross or histological abnormalities. However dopamine levels in the frontal cortex of males are increased. Also, males show increased aggression and females show increased anxiety. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 24 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ak8 |
T |
C |
2: 28,702,910 (GRCm39) |
S425P |
probably damaging |
Het |
Cplane1 |
A |
T |
15: 8,247,921 (GRCm39) |
H1490L |
possibly damaging |
Het |
Exoc6 |
T |
C |
19: 37,597,402 (GRCm39) |
I601T |
probably damaging |
Het |
F11 |
A |
T |
8: 45,694,568 (GRCm39) |
C598S |
probably damaging |
Het |
Galnt13 |
G |
T |
2: 55,002,872 (GRCm39) |
D524Y |
probably damaging |
Het |
Glb1l3 |
T |
C |
9: 26,764,940 (GRCm39) |
E157G |
probably damaging |
Het |
Hc |
T |
C |
2: 34,890,847 (GRCm39) |
H1323R |
probably benign |
Het |
Hsd3b5 |
T |
C |
3: 98,537,421 (GRCm39) |
I32V |
probably benign |
Het |
Il6ra |
A |
G |
3: 89,778,560 (GRCm39) |
S430P |
probably benign |
Het |
Lama2 |
G |
T |
10: 27,242,062 (GRCm39) |
T298K |
probably damaging |
Het |
Nedd4l |
T |
C |
18: 65,341,116 (GRCm39) |
|
probably benign |
Het |
Ntrk3 |
T |
C |
7: 78,103,085 (GRCm39) |
D405G |
probably benign |
Het |
Opn5 |
T |
C |
17: 42,868,382 (GRCm39) |
D371G |
probably benign |
Het |
Pcdh15 |
G |
T |
10: 74,152,918 (GRCm39) |
A408S |
probably damaging |
Het |
Pim3 |
T |
C |
15: 88,747,116 (GRCm39) |
V54A |
probably benign |
Het |
Prdm5 |
T |
C |
6: 65,771,303 (GRCm39) |
F38S |
probably damaging |
Het |
Ptgs2 |
C |
T |
1: 149,981,460 (GRCm39) |
|
probably null |
Het |
Rnf185 |
A |
G |
11: 3,368,015 (GRCm39) |
I221T |
possibly damaging |
Het |
Slc27a2 |
T |
C |
2: 126,420,870 (GRCm39) |
F318L |
possibly damaging |
Het |
Spata1 |
T |
C |
3: 146,193,119 (GRCm39) |
Y124C |
possibly damaging |
Het |
Tmie |
G |
T |
9: 110,699,821 (GRCm39) |
|
probably benign |
Het |
Tph2 |
T |
C |
10: 114,915,886 (GRCm39) |
K429R |
probably benign |
Het |
Usp32 |
A |
G |
11: 84,935,613 (GRCm39) |
Y388H |
probably benign |
Het |
Vmn2r60 |
A |
T |
7: 41,844,578 (GRCm39) |
Q647L |
probably benign |
Het |
|
Other mutations in Comt |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02568:Comt
|
APN |
16 |
18,230,454 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03286:Comt
|
APN |
16 |
18,230,490 (GRCm39) |
missense |
probably damaging |
1.00 |
R0845:Comt
|
UTSW |
16 |
18,226,711 (GRCm39) |
missense |
probably damaging |
1.00 |
R1318:Comt
|
UTSW |
16 |
18,226,641 (GRCm39) |
missense |
probably damaging |
1.00 |
R1541:Comt
|
UTSW |
16 |
18,230,565 (GRCm39) |
missense |
probably benign |
0.20 |
R4496:Comt
|
UTSW |
16 |
18,230,437 (GRCm39) |
splice site |
probably null |
|
R5619:Comt
|
UTSW |
16 |
18,230,469 (GRCm39) |
missense |
probably damaging |
1.00 |
R6753:Comt
|
UTSW |
16 |
18,226,771 (GRCm39) |
missense |
probably benign |
0.01 |
R7286:Comt
|
UTSW |
16 |
18,229,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R8061:Comt
|
UTSW |
16 |
18,230,040 (GRCm39) |
missense |
probably benign |
0.00 |
R8419:Comt
|
UTSW |
16 |
18,230,637 (GRCm39) |
nonsense |
probably null |
|
R8872:Comt
|
UTSW |
16 |
18,245,239 (GRCm39) |
unclassified |
probably benign |
|
|
Posted On |
2015-04-16 |