Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02369:Gpr146'

290849

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr146

Ensembl Gene

ENSMUSG00000044197

Gene Name

G protein-coupled receptor 146

Synonyms

PGR8

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02369

Quality Score

Status

Chromosome

Chromosomal Location

139363452-139382170 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 139378443 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 82 (Y82H)

Ref Sequence

ENSEMBL: ENSMUSP00000119464 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051293] [ENSMUST00000066052] [ENSMUST00000100514] [ENSMUST00000138631] [ENSMUST00000198474]

AlphaFold

Q99LE2

Predicted Effect

probably benign
Transcript: ENSMUST00000051293
AA Change: Y82H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000049707
Gene: ENSMUSG00000044197
AA Change: Y82H

Domain	Start	End	E-Value	Type
low complexity region	21	36	N/A	INTRINSIC
Pfam:7tm_1	43	294	2e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000066052

SMART Domains

Protein: ENSMUSP00000069230
Gene: ENSMUSG00000053553

Domain	Start	End	E-Value	Type
low complexity region	54	77	N/A	INTRINSIC
Pfam:DUF2373	103	165	3e-26	PFAM
low complexity region	184	194	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000100514
AA Change: Y82H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000098083
Gene: ENSMUSG00000044197
AA Change: Y82H

Domain	Start	End	E-Value	Type
low complexity region	21	36	N/A	INTRINSIC
Pfam:7tm_1	43	294	1.6e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138631
AA Change: Y82H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000119464
Gene: ENSMUSG00000044197
AA Change: Y82H

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	26	80	3e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196267

Predicted Effect

probably benign
Transcript: ENSMUST00000198474

SMART Domains

Protein: ENSMUSP00000142949
Gene: ENSMUSG00000053553

Domain	Start	End	E-Value	Type
low complexity region	54	77	N/A	INTRINSIC
Pfam:DUF2373	102	141	9e-12	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck2	G	T	6: 39,551,678 (GRCm39)	L148F	probably damaging	Het
Arhgef10	G	A	8: 15,047,551 (GRCm39)	R1138H	probably damaging	Het
Arpp21	T	C	9: 111,948,266 (GRCm39)	T668A	probably benign	Het
Atp6v0b	T	A	4: 117,742,850 (GRCm39)	I79F	possibly damaging	Het
Atp8b5	A	T	4: 43,334,205 (GRCm39)	N324Y	probably benign	Het
Bach2	A	G	4: 32,579,975 (GRCm39)	I610M	possibly damaging	Het
Casr	G	T	16: 36,315,051 (GRCm39)	D929E	probably benign	Het
Cbln2	T	C	18: 86,731,479 (GRCm39)	S96P	probably damaging	Het
Cpxm1	T	C	2: 130,238,344 (GRCm39)	K73E	probably damaging	Het
Erap1	A	G	13: 74,814,645 (GRCm39)	Y457C	probably benign	Het
Etl4	T	C	2: 20,535,000 (GRCm39)	Y152H	probably damaging	Het
Fbh1	A	T	2: 11,751,969 (GRCm39)	S910T	possibly damaging	Het
Gm10142	T	C	10: 77,551,947 (GRCm39)	S103P	probably benign	Het
Gm12886	A	G	4: 121,280,229 (GRCm39)	S16P	unknown	Het
Herc1	C	T	9: 66,399,293 (GRCm39)	Q4282*	probably null	Het
Htr2a	A	T	14: 74,943,722 (GRCm39)	E434V	probably benign	Het
Iqsec3	T	C	6: 121,389,893 (GRCm39)		probably benign	Het
Islr	A	C	9: 58,064,907 (GRCm39)	V200G	probably damaging	Het
Katnal1	T	C	5: 148,815,737 (GRCm39)	D400G	probably benign	Het
Lonrf2	A	G	1: 38,850,913 (GRCm39)		probably benign	Het
Lrp2	A	T	2: 69,294,980 (GRCm39)	L3446Q	probably damaging	Het
Med12l	G	A	3: 59,164,794 (GRCm39)	V1425I	probably benign	Het
Myh13	T	C	11: 67,251,100 (GRCm39)		probably benign	Het
Nutm2	T	G	13: 50,623,944 (GRCm39)	S214A	probably benign	Het
Or10aa1	T	A	1: 173,869,539 (GRCm39)	W8R	possibly damaging	Het
Or2h1b	A	G	17: 37,462,665 (GRCm39)	F66S	probably damaging	Het
Or5b99	T	C	19: 12,977,072 (GRCm39)	S241P	probably damaging	Het
Or6c33	C	A	10: 129,853,425 (GRCm39)	A65E	possibly damaging	Het
Pax5	A	T	4: 44,691,919 (GRCm39)	M109K	probably damaging	Het
Pfkfb2	G	A	1: 130,628,572 (GRCm39)	R345W	probably damaging	Het
Pkd1l3	A	G	8: 110,342,977 (GRCm39)	D105G	unknown	Het
Prdm11	A	G	2: 92,805,864 (GRCm39)	V362A	probably benign	Het
Prex2	T	C	1: 11,171,393 (GRCm39)		probably null	Het
Prl8a1	T	C	13: 27,760,924 (GRCm39)	T103A	possibly damaging	Het
Rgl1	T	C	1: 152,409,357 (GRCm39)	I493V	probably damaging	Het
Rimkla	A	G	4: 119,335,146 (GRCm39)	V79A	possibly damaging	Het
Ryr2	A	T	13: 11,634,382 (GRCm39)	S3791R	possibly damaging	Het
Sh3rf2	C	A	18: 42,289,222 (GRCm39)	S681*	probably null	Het
Stmnd1	T	A	13: 46,439,029 (GRCm39)	I87K	probably benign	Het
Tspan8	C	A	10: 115,675,782 (GRCm39)	F149L	probably benign	Het
Tspan8	A	C	10: 115,675,783 (GRCm39)	K150Q	probably benign	Het
Ttn	T	C	2: 76,772,720 (GRCm39)	E2425G	probably damaging	Het

Other mutations in Gpr146

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01355:Gpr146	APN	5	139,364,659 (GRCm39)	intron	probably benign
IGL02152:Gpr146	APN	5	139,378,467 (GRCm39)	missense	probably damaging	1.00
IGL02392:Gpr146	APN	5	139,378,533 (GRCm39)	missense	probably damaging	0.99
IGL02828:Gpr146	APN	5	139,378,576 (GRCm39)	missense	probably damaging	0.97
IGL03095:Gpr146	APN	5	139,378,705 (GRCm39)	missense	probably benign	0.11
R0360:Gpr146	UTSW	5	139,364,933 (GRCm39)	intron	probably benign
R0364:Gpr146	UTSW	5	139,364,933 (GRCm39)	intron	probably benign
R0746:Gpr146	UTSW	5	139,378,977 (GRCm39)	missense	probably damaging	1.00
R1446:Gpr146	UTSW	5	139,379,177 (GRCm39)	missense	probably benign	0.00
R1507:Gpr146	UTSW	5	139,379,124 (GRCm39)	missense	probably benign
R1758:Gpr146	UTSW	5	139,379,137 (GRCm39)	missense	probably benign	0.34
R2032:Gpr146	UTSW	5	139,364,902 (GRCm39)	intron	probably benign
R6513:Gpr146	UTSW	5	139,378,573 (GRCm39)	missense	probably damaging	1.00
R6797:Gpr146	UTSW	5	139,378,795 (GRCm39)	missense	possibly damaging	0.79
R7830:Gpr146	UTSW	5	139,378,357 (GRCm39)	missense	probably benign	0.02
R7977:Gpr146	UTSW	5	139,378,440 (GRCm39)	missense	possibly damaging	0.53
R7987:Gpr146	UTSW	5	139,378,440 (GRCm39)	missense	possibly damaging	0.53
R8225:Gpr146	UTSW	5	139,378,371 (GRCm39)	missense	probably benign	0.03
R8792:Gpr146	UTSW	5	139,378,549 (GRCm39)	missense	probably damaging	1.00
R9354:Gpr146	UTSW	5	139,378,366 (GRCm39)	missense	probably benign	0.00
X0064:Gpr146	UTSW	5	139,364,664 (GRCm39)	intron	probably benign

Posted On

2015-04-16