Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00974:Fyb1'

29101

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fyb1

Ensembl Gene

ENSMUSG00000022148

Gene Name

FYN binding protein 1

Synonyms

B630013F22Rik, Fyb, ADAP, FYB-120/130

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00974

Quality Score

Status

Chromosome

Chromosomal Location

6552334-6692794 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 6672066 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090461]

AlphaFold

O35601

Predicted Effect

probably benign
Transcript: ENSMUST00000090461

SMART Domains

Protein: ENSMUSP00000087947
Gene: ENSMUSG00000022148

Domain	Start	End	E-Value	Type
low complexity region	67	85	N/A	INTRINSIC
low complexity region	149	160	N/A	INTRINSIC
low complexity region	236	246	N/A	INTRINSIC
low complexity region	335	353	N/A	INTRINSIC
low complexity region	371	409	N/A	INTRINSIC
low complexity region	440	451	N/A	INTRINSIC
low complexity region	457	494	N/A	INTRINSIC
SH3	502	559	1.24e-3	SMART
low complexity region	611	626	N/A	INTRINSIC
Pfam:hSH3	731	819	2.9e-46	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159604

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160698

Predicted Effect

probably benign
Transcript: ENSMUST00000163073

SMART Domains

Protein: ENSMUSP00000123895
Gene: ENSMUSG00000022148

Domain	Start	End	E-Value	Type
low complexity region	12	27	N/A	INTRINSIC
Pfam:hSH3	86	170	4.1e-42	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased T cell proliferation, thymocytes and platelet counts and decreased TCR-stimulated leukocyte adhesion. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Brwd1	T	A	16: 95,844,226 (GRCm39)	K776M	probably damaging	Het
Crisp4	T	C	1: 18,198,871 (GRCm39)	T188A	probably damaging	Het
E130311K13Rik	T	A	3: 63,827,784 (GRCm39)		probably null	Het
Gcn1	G	A	5: 115,751,852 (GRCm39)	V2076M	possibly damaging	Het
Grik5	A	T	7: 24,713,310 (GRCm39)	I766N	probably damaging	Het
Grk3	A	G	5: 113,133,685 (GRCm39)	Y46H	probably damaging	Het
Gtf2a1l	A	G	17: 89,022,377 (GRCm39)	D456G	probably damaging	Het
Kcna10	A	G	3: 107,102,647 (GRCm39)	D426G	probably damaging	Het
Luzp2	A	T	7: 54,724,774 (GRCm39)	I112F	probably damaging	Het
Med12l	G	T	3: 58,990,435 (GRCm39)	R519M	probably damaging	Het
Mrpl39	G	A	16: 84,520,740 (GRCm39)	P300S	probably damaging	Het
Polr3a	A	T	14: 24,529,492 (GRCm39)	I328N	probably benign	Het
Slc22a8	A	G	19: 8,587,290 (GRCm39)	N450S	probably damaging	Het
Slc38a4	T	C	15: 96,897,397 (GRCm39)	T473A	probably benign	Het
Slc4a7	C	T	14: 14,760,292 (GRCm38)	P576S	probably benign	Het
Tecta	A	G	9: 42,242,670 (GRCm39)	I2057T	probably benign	Het
Tnks1bp1	C	T	2: 84,893,226 (GRCm39)	T389I	possibly damaging	Het
Tnxb	T	C	17: 34,937,707 (GRCm39)		probably null	Het
Tsc22d1	A	G	14: 76,743,882 (GRCm39)	Y10C	probably damaging	Het
Vmn1r34	T	C	6: 66,614,639 (GRCm39)	H33R	possibly damaging	Het
Vmn2r102	G	T	17: 19,897,771 (GRCm39)	W262L	possibly damaging	Het

Other mutations in Fyb1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00417:Fyb1	APN	15	6,610,258 (GRCm39)	missense	probably damaging	0.99
IGL00801:Fyb1	APN	15	6,674,305 (GRCm39)	missense	possibly damaging	0.86
IGL01377:Fyb1	APN	15	6,609,801 (GRCm39)	missense	probably benign	0.01
IGL01982:Fyb1	APN	15	6,609,658 (GRCm39)	missense	probably null	0.99
IGL02173:Fyb1	APN	15	6,610,176 (GRCm39)	missense	probably benign	0.00
IGL02177:Fyb1	APN	15	6,688,047 (GRCm39)	critical splice donor site	probably null
IGL02345:Fyb1	APN	15	6,649,143 (GRCm39)	missense	possibly damaging	0.94
IGL02695:Fyb1	APN	15	6,610,402 (GRCm39)	missense	probably damaging	1.00
IGL02820:Fyb1	APN	15	6,688,040 (GRCm39)	missense	possibly damaging	0.65
IGL02867:Fyb1	APN	15	6,609,527 (GRCm39)	missense	probably damaging	1.00
baddie	UTSW	15	6,681,972 (GRCm39)	missense	probably damaging	1.00
luegner	UTSW	15	6,610,350 (GRCm39)	nonsense	probably null
uebeltaeter	UTSW	15	6,668,388 (GRCm39)	missense	probably damaging	1.00
P0023:Fyb1	UTSW	15	6,681,335 (GRCm39)	missense	probably damaging	1.00
R0028:Fyb1	UTSW	15	6,674,395 (GRCm39)	intron	probably benign
R0364:Fyb1	UTSW	15	6,610,272 (GRCm39)	missense	probably damaging	1.00
R0507:Fyb1	UTSW	15	6,664,297 (GRCm39)	missense	probably benign	0.39
R0588:Fyb1	UTSW	15	6,609,940 (GRCm39)	missense	probably benign	0.03
R0742:Fyb1	UTSW	15	6,664,297 (GRCm39)	missense	probably benign	0.39
R0930:Fyb1	UTSW	15	6,668,309 (GRCm39)	missense	probably damaging	1.00
R1184:Fyb1	UTSW	15	6,668,381 (GRCm39)	missense	probably damaging	1.00
R1446:Fyb1	UTSW	15	6,681,947 (GRCm39)	missense	probably benign	0.02
R1481:Fyb1	UTSW	15	6,649,128 (GRCm39)	missense	probably benign	0.01
R1711:Fyb1	UTSW	15	6,609,960 (GRCm39)	missense	probably damaging	1.00
R2041:Fyb1	UTSW	15	6,674,268 (GRCm39)	missense	possibly damaging	0.78
R2176:Fyb1	UTSW	15	6,609,435 (GRCm39)	missense	probably damaging	1.00
R2224:Fyb1	UTSW	15	6,681,864 (GRCm39)	missense	probably damaging	1.00
R2372:Fyb1	UTSW	15	6,681,388 (GRCm39)	splice site	probably benign
R3236:Fyb1	UTSW	15	6,659,597 (GRCm39)	missense	probably damaging	0.96
R4117:Fyb1	UTSW	15	6,659,597 (GRCm39)	missense	probably damaging	0.96
R4181:Fyb1	UTSW	15	6,610,404 (GRCm39)	missense	probably benign	0.00
R4322:Fyb1	UTSW	15	6,610,300 (GRCm39)	missense	possibly damaging	0.84
R4952:Fyb1	UTSW	15	6,668,292 (GRCm39)	missense	probably damaging	1.00
R4981:Fyb1	UTSW	15	6,676,092 (GRCm39)	splice site	probably benign
R5055:Fyb1	UTSW	15	6,614,630 (GRCm39)	unclassified	probably benign
R5368:Fyb1	UTSW	15	6,610,159 (GRCm39)	splice site	probably null
R5719:Fyb1	UTSW	15	6,610,350 (GRCm39)	nonsense	probably null
R5822:Fyb1	UTSW	15	6,692,707 (GRCm39)	unclassified	probably benign
R6064:Fyb1	UTSW	15	6,668,349 (GRCm39)	missense	probably damaging	1.00
R6929:Fyb1	UTSW	15	6,668,388 (GRCm39)	missense	probably damaging	1.00
R7125:Fyb1	UTSW	15	6,674,337 (GRCm39)	missense	possibly damaging	0.77
R7243:Fyb1	UTSW	15	6,673,180 (GRCm39)	missense	probably benign	0.19
R7748:Fyb1	UTSW	15	6,668,307 (GRCm39)	missense	probably damaging	1.00
R7750:Fyb1	UTSW	15	6,690,184 (GRCm39)	missense	probably damaging	1.00
R7902:Fyb1	UTSW	15	6,690,197 (GRCm39)	critical splice donor site	probably null
R8182:Fyb1	UTSW	15	6,681,293 (GRCm39)	missense	probably benign
R8841:Fyb1	UTSW	15	6,681,972 (GRCm39)	missense	probably damaging	1.00
R9103:Fyb1	UTSW	15	6,673,232 (GRCm39)	missense	possibly damaging	0.66
R9256:Fyb1	UTSW	15	6,674,358 (GRCm39)	missense	possibly damaging	0.61
R9385:Fyb1	UTSW	15	6,664,297 (GRCm39)	missense	probably benign	0.39
R9739:Fyb1	UTSW	15	6,670,063 (GRCm39)	missense	probably benign	0.00
Z1088:Fyb1	UTSW	15	6,688,021 (GRCm39)	missense	probably benign	0.41

Posted On

2013-04-17