Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02375:Tcp11l2'

291088

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tcp11l2

Ensembl Gene

ENSMUSG00000020034

Gene Name

t-complex 11 (mouse) like 2

Synonyms

E430026E19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.128) question?

Stock #

IGL02375

Quality Score

Status

Chromosome

Chromosomal Location

84412811-84450219 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

G to A at 84440932 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000020223 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020223] [ENSMUST00000020223]

AlphaFold

Q8K1H7

Predicted Effect

probably null
Transcript: ENSMUST00000020223

SMART Domains

Protein: ENSMUSP00000020223
Gene: ENSMUSG00000020034

Domain	Start	End	E-Value	Type
low complexity region	11	21	N/A	INTRINSIC
low complexity region	36	55	N/A	INTRINSIC
Pfam:Tcp11	77	497	5.8e-103	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000020223

SMART Domains

Protein: ENSMUSP00000020223
Gene: ENSMUSG00000020034

Domain	Start	End	E-Value	Type
low complexity region	11	21	N/A	INTRINSIC
low complexity region	36	55	N/A	INTRINSIC
Pfam:Tcp11	77	497	5.8e-103	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160057

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700034J05Rik	T	A	6: 146,854,813 (GRCm39)	K76N	possibly damaging	Het
Agxt	A	G	1: 93,063,425 (GRCm39)	E109G	probably damaging	Het
Alcam	T	C	16: 52,109,299 (GRCm39)	T325A	probably benign	Het
Apol7c	T	C	15: 77,413,049 (GRCm39)	E67G	probably damaging	Het
Bco1	C	A	8: 117,840,178 (GRCm39)	S232Y	probably benign	Het
Cacna1c	A	T	6: 118,652,884 (GRCm39)	V763D	probably damaging	Het
Ccdc15	T	C	9: 37,215,628 (GRCm39)	D618G	probably damaging	Het
Cimip1	A	G	2: 173,364,496 (GRCm39)	M14V	probably benign	Het
Col6a5	T	C	9: 105,783,312 (GRCm39)	N1603S	unknown	Het
Cyp4v3	A	G	8: 45,761,411 (GRCm39)		probably null	Het
Eml5	A	T	12: 98,810,346 (GRCm39)	V870E	probably damaging	Het
Epn2	A	G	11: 61,410,497 (GRCm39)	V512A	probably damaging	Het
Farp2	A	G	1: 93,504,185 (GRCm39)	R321G	probably damaging	Het
Garin3	G	T	11: 46,297,379 (GRCm39)	V228L	probably damaging	Het
Gprasp1	T	C	X: 134,701,552 (GRCm39)	S582P	probably damaging	Het
Grhl2	T	C	15: 37,291,821 (GRCm39)	V303A	probably damaging	Het
Grik1	A	T	16: 87,743,444 (GRCm39)	F594L	probably damaging	Het
Hivep1	A	G	13: 42,309,925 (GRCm39)	K722E	probably benign	Het
Htr5b	G	A	1: 121,455,564 (GRCm39)	R119C	probably damaging	Het
Ifit2	T	C	19: 34,551,737 (GRCm39)	S426P	probably benign	Het
Kif13a	T	C	13: 46,978,698 (GRCm39)	Y234C	probably damaging	Het
Mios	T	A	6: 8,222,598 (GRCm39)	F511I	probably benign	Het
Mtfmt	T	C	9: 65,346,849 (GRCm39)	W148R	probably damaging	Het
Myo1c	C	A	11: 75,552,400 (GRCm39)	T391N	probably benign	Het
Nlrp1a	A	T	11: 71,004,339 (GRCm39)	L710*	probably null	Het
Nlrp1b	A	G	11: 71,052,506 (GRCm39)	I971T	probably damaging	Het
Nup43	A	G	10: 7,549,358 (GRCm39)	D171G	probably damaging	Het
Or5b12b	A	G	19: 12,861,305 (GRCm39)	E20G	probably benign	Het
P2rx7	T	C	5: 122,811,719 (GRCm39)		probably benign	Het
Pgap6	T	A	17: 26,338,473 (GRCm39)	Y512N	probably benign	Het
Poli	C	T	18: 70,656,363 (GRCm39)	G155R	probably damaging	Het
Rad9b	T	C	5: 122,471,405 (GRCm39)	S220G	possibly damaging	Het
Rgn	C	T	X: 20,416,700 (GRCm39)	S28L	probably damaging	Het
Tenm4	G	A	7: 96,353,344 (GRCm39)	V379I	possibly damaging	Het
Thsd7a	A	T	6: 12,343,264 (GRCm39)	C1118S	probably damaging	Het
Trpm7	A	G	2: 126,667,664 (GRCm39)	Y776H	probably damaging	Het
Trpv4	T	C	5: 114,774,418 (GRCm39)	N222S	probably benign	Het
Tut1	C	T	19: 8,941,403 (GRCm39)	R397C	probably damaging	Het
Vmn1r72	T	A	7: 11,403,672 (GRCm39)	T259S	probably benign	Het
Wdr17	A	G	8: 55,149,423 (GRCm39)	S2P	possibly damaging	Het

Other mutations in Tcp11l2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00725:Tcp11l2	APN	10	84,430,574 (GRCm39)	missense	possibly damaging	0.82
IGL00845:Tcp11l2	APN	10	84,440,847 (GRCm39)	missense	possibly damaging	0.95
IGL02418:Tcp11l2	APN	10	84,449,470 (GRCm39)	nonsense	probably null
IGL03325:Tcp11l2	APN	10	84,440,764 (GRCm39)	missense	possibly damaging	0.76
R0031:Tcp11l2	UTSW	10	84,427,004 (GRCm39)	missense	probably damaging	0.98
R0591:Tcp11l2	UTSW	10	84,440,458 (GRCm39)	missense	probably benign	0.05
R1563:Tcp11l2	UTSW	10	84,420,808 (GRCm39)	missense	probably damaging	0.96
R1607:Tcp11l2	UTSW	10	84,449,351 (GRCm39)	missense	probably damaging	1.00
R1840:Tcp11l2	UTSW	10	84,440,463 (GRCm39)	missense	probably damaging	0.98
R2144:Tcp11l2	UTSW	10	84,449,363 (GRCm39)	missense	probably damaging	1.00
R2251:Tcp11l2	UTSW	10	84,440,933 (GRCm39)	critical splice donor site	probably null
R4289:Tcp11l2	UTSW	10	84,440,937 (GRCm39)	splice site	probably null
R4639:Tcp11l2	UTSW	10	84,420,800 (GRCm39)	missense	probably damaging	1.00
R4844:Tcp11l2	UTSW	10	84,449,555 (GRCm39)	missense	probably benign	0.00
R4973:Tcp11l2	UTSW	10	84,427,027 (GRCm39)	missense	probably damaging	0.98
R5264:Tcp11l2	UTSW	10	84,449,524 (GRCm39)	missense	probably damaging	1.00
R5970:Tcp11l2	UTSW	10	84,430,661 (GRCm39)	splice site	probably benign
R6966:Tcp11l2	UTSW	10	84,427,133 (GRCm39)	missense	possibly damaging	0.79
R7250:Tcp11l2	UTSW	10	84,423,105 (GRCm39)	critical splice donor site	probably null
R7535:Tcp11l2	UTSW	10	84,430,523 (GRCm39)	missense	possibly damaging	0.67
R7565:Tcp11l2	UTSW	10	84,422,998 (GRCm39)	missense	probably damaging	1.00
R7619:Tcp11l2	UTSW	10	84,430,622 (GRCm39)	missense	probably damaging	1.00
R7774:Tcp11l2	UTSW	10	84,440,847 (GRCm39)	missense	possibly damaging	0.95
R8145:Tcp11l2	UTSW	10	84,444,480 (GRCm39)	missense	probably damaging	1.00
R8379:Tcp11l2	UTSW	10	84,449,469 (GRCm39)	missense	probably damaging	1.00
R8458:Tcp11l2	UTSW	10	84,449,396 (GRCm39)	nonsense	probably null
R8821:Tcp11l2	UTSW	10	84,449,522 (GRCm39)	missense	probably damaging	1.00
R8831:Tcp11l2	UTSW	10	84,449,522 (GRCm39)	missense	probably damaging	1.00
RF008:Tcp11l2	UTSW	10	84,449,388 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16