Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02377:Slc35g1'

291181

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35g1

Ensembl Gene

ENSMUSG00000044026

Gene Name

solute carrier family 35, member G1

Synonyms

Tmem20, D330039I19Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02377

Quality Score

Status

Chromosome

Chromosomal Location

38384428-38394055 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 38391678 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 320 (M320K)

Ref Sequence

ENSEMBL: ENSMUSP00000061282 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054098]

AlphaFold

Q8BY79

Predicted Effect

possibly damaging
Transcript: ENSMUST00000054098
AA Change: M320K

PolyPhen 2 Score 0.792 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000061282
Gene: ENSMUSG00000044026
AA Change: M320K

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
Pfam:EamA	72	205	2.3e-20	PFAM
Pfam:SLC35F	72	280	3.9e-7	PFAM
Pfam:EamA	225	360	3.3e-9	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane protein which is a member of the drug/metabolite transporter protein superfamily. The encoded protein may play a role in the regulation of calcium levels inside the cell. [provided by RefSeq, Sep 2016]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aatk	A	T	11: 119,937,689 (GRCm39)		probably benign	Het
Abca15	T	C	7: 119,965,133 (GRCm39)		probably benign	Het
App	T	C	16: 84,879,719 (GRCm39)	Q138R	probably benign	Het
Asah2	T	A	19: 31,986,814 (GRCm39)	I529F	probably benign	Het
Atp8b3	A	G	10: 80,356,128 (GRCm39)	S1195P	probably benign	Het
Brca1	A	G	11: 101,415,149 (GRCm39)	M134T	probably benign	Het
Cacna1s	T	C	1: 135,996,732 (GRCm39)	L111P	probably damaging	Het
Capns2	A	T	8: 93,628,215 (GRCm39)	N35Y	probably benign	Het
Ccne1	A	G	7: 37,798,415 (GRCm39)		probably null	Het
Cfap91	G	T	16: 38,153,181 (GRCm39)		probably benign	Het
Csf1r	G	T	18: 61,257,540 (GRCm39)		probably benign	Het
Dipk2b	T	A	X: 18,313,930 (GRCm39)	I131F	possibly damaging	Het
Dlg3	A	T	X: 99,817,007 (GRCm39)	Y326F	possibly damaging	Het
Dnah8	T	C	17: 31,013,770 (GRCm39)	V3837A	probably damaging	Het
Dock10	A	G	1: 80,562,711 (GRCm39)		probably null	Het
Emg1	A	G	6: 124,681,620 (GRCm39)	V208A	probably benign	Het
Eml6	T	A	11: 29,727,282 (GRCm39)	D1280V	probably damaging	Het
Ep400	T	C	5: 110,868,691 (GRCm39)	D911G	unknown	Het
Fam171a1	T	C	2: 3,224,623 (GRCm39)		probably null	Het
Fcgbp	T	C	7: 27,806,395 (GRCm39)	V2121A	possibly damaging	Het
Fggy	G	A	4: 95,511,714 (GRCm39)		probably benign	Het
Fignl1	G	T	11: 11,752,845 (GRCm39)	T70K	possibly damaging	Het
Fndc3b	T	C	3: 27,674,801 (GRCm39)	E47G	probably damaging	Het
Frmd4a	A	G	2: 4,539,385 (GRCm39)	K189E	possibly damaging	Het
Hpse	T	A	5: 100,839,199 (GRCm39)	Y383F	probably damaging	Het
Ip6k2	T	C	9: 108,681,798 (GRCm39)	L197P	probably damaging	Het
Klf1	A	C	8: 85,631,561 (GRCm39)	H375P	probably damaging	Het
Krtap6-5	T	A	16: 88,844,734 (GRCm39)		probably benign	Het
Lacc1	A	T	14: 77,267,055 (GRCm39)	S403T	probably damaging	Het
Lama3	A	G	18: 12,689,807 (GRCm39)	I2850V	possibly damaging	Het
Lats2	C	T	14: 57,929,052 (GRCm39)	R941Q	probably damaging	Het
Lgals3bp	A	T	11: 118,284,290 (GRCm39)	Y430N	probably benign	Het
Lrig3	A	T	10: 125,850,743 (GRCm39)	H1103L	probably benign	Het
Lrrc40	G	A	3: 157,742,365 (GRCm39)	M1I	probably null	Het
Magee2	A	T	X: 103,900,399 (GRCm39)	V84D	possibly damaging	Het
Msantd2	G	A	9: 37,434,602 (GRCm39)	V281I	possibly damaging	Het
Mycbpap	A	G	11: 94,394,076 (GRCm39)	V340A	probably damaging	Het
Myh6	A	T	14: 55,181,775 (GRCm39)	M1842K	probably benign	Het
Mylk4	T	C	13: 32,906,130 (GRCm39)	D145G	possibly damaging	Het
Nfkbid	C	T	7: 30,124,689 (GRCm39)	Q160*	probably null	Het
Or11h6	T	A	14: 50,879,975 (GRCm39)		probably null	Het
Or2y1d	A	T	11: 49,321,859 (GRCm39)	K185N	probably damaging	Het
Or5w1b	T	A	2: 87,475,630 (GRCm39)	Y279F	probably damaging	Het
Or7e168	C	T	9: 19,720,343 (GRCm39)	S243F	probably damaging	Het
Or8c11	A	T	9: 38,289,542 (GRCm39)	T122S	probably damaging	Het
Or9q2	T	G	19: 13,772,693 (GRCm39)	Q94P	possibly damaging	Het
Pdgfrb	A	C	18: 61,213,404 (GRCm39)	Q916P	probably damaging	Het
Pex14	T	C	4: 149,050,743 (GRCm39)	Q174R	probably benign	Het
Pogz	T	C	3: 94,786,321 (GRCm39)	S970P	probably damaging	Het
Potegl	T	C	2: 23,102,667 (GRCm39)		probably benign	Het
Rabggta	A	G	14: 55,955,952 (GRCm39)	V165A	possibly damaging	Het
Rdh10	G	A	1: 16,176,438 (GRCm39)	W66*	probably null	Het
Ripor2	T	A	13: 24,879,549 (GRCm39)		probably benign	Het
Slc9a7	A	G	X: 20,068,963 (GRCm39)	Y197H	probably damaging	Het
Smn1	T	C	13: 100,272,192 (GRCm39)		probably benign	Het
Spam1	G	A	6: 24,796,696 (GRCm39)	G216S	probably damaging	Het
Spata31	A	T	13: 65,068,194 (GRCm39)	N114I	probably damaging	Het
Sptbn1	A	T	11: 30,069,491 (GRCm39)	V1615D	possibly damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Thoc2	T	A	X: 40,914,355 (GRCm39)	Q1005H	possibly damaging	Het
Thra	G	A	11: 98,652,742 (GRCm39)	R189Q	probably damaging	Het
Trappc11	A	T	8: 47,983,685 (GRCm39)		probably null	Het
Vps13d	G	T	4: 144,882,934 (GRCm39)	H886Q	probably damaging	Het
Zfp157	G	A	5: 138,445,859 (GRCm39)	W71*	probably null	Het

Other mutations in Slc35g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01866:Slc35g1	APN	19	38,391,642 (GRCm39)	missense	probably damaging	1.00
IGL02322:Slc35g1	APN	19	38,389,013 (GRCm39)	nonsense	probably null
R1464:Slc35g1	UTSW	19	38,391,665 (GRCm39)	missense	probably benign	0.01
R1464:Slc35g1	UTSW	19	38,391,665 (GRCm39)	missense	probably benign	0.01
R2119:Slc35g1	UTSW	19	38,391,735 (GRCm39)	missense	probably benign	0.05
R4814:Slc35g1	UTSW	19	38,391,275 (GRCm39)	missense	possibly damaging	0.58
R5229:Slc35g1	UTSW	19	38,391,080 (GRCm39)	splice site	probably null
R7176:Slc35g1	UTSW	19	38,391,771 (GRCm39)	missense	probably damaging	1.00
R7707:Slc35g1	UTSW	19	38,391,571 (GRCm39)	nonsense	probably null
R8108:Slc35g1	UTSW	19	38,391,279 (GRCm39)	missense	probably damaging	1.00
R8108:Slc35g1	UTSW	19	38,391,277 (GRCm39)	missense	probably damaging	1.00
R8253:Slc35g1	UTSW	19	38,391,237 (GRCm39)	missense	probably damaging	1.00
R9300:Slc35g1	UTSW	19	38,384,633 (GRCm39)	missense	probably benign	0.23

Posted On

2015-04-16