Incidental Mutation 'IGL02385:Prl3b1'
ID 291511
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prl3b1
Ensembl Gene ENSMUSG00000038891
Gene Name prolactin family 3, subfamily b, member 1
Synonyms mplII, PL, Pl-2, mPL-II, Pl2, prolactin-like, Csh2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL02385
Quality Score
Status
Chromosome 13
Chromosomal Location 27426413-27433666 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27433366 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 174 (S174P)
Ref Sequence ENSEMBL: ENSMUSP00000047680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035273] [ENSMUST00000225089]
AlphaFold P09586
Predicted Effect possibly damaging
Transcript: ENSMUST00000035273
AA Change: S174P

PolyPhen 2 Score 0.508 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000047680
Gene: ENSMUSG00000038891
AA Change: S174P

DomainStartEndE-ValueType
Pfam:Hormone_1 18 222 1e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225089
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,201,630 (GRCm39) D351E probably damaging Het
Adad2 A G 8: 120,341,773 (GRCm39) probably benign Het
Adamts8 A G 9: 30,873,026 (GRCm39) N744D probably benign Het
Atad5 C T 11: 79,985,453 (GRCm39) T180I probably benign Het
Atp2a3 C A 11: 72,866,165 (GRCm39) H262N probably benign Het
Bcl9 A T 3: 97,116,594 (GRCm39) I700K probably benign Het
Bcr T C 10: 74,981,235 (GRCm39) S685P probably damaging Het
Cd36 A G 5: 18,019,717 (GRCm39) V128A probably benign Het
Cfap20dc A G 14: 8,510,920 (GRCm38) V498A possibly damaging Het
Chd2 T C 7: 73,085,570 (GRCm39) Y1688C probably damaging Het
Csmd1 A G 8: 15,953,275 (GRCm39) V3402A probably benign Het
Dsg3 T C 18: 20,660,771 (GRCm39) V370A probably damaging Het
Dus4l A G 12: 31,690,674 (GRCm39) probably benign Het
Fcrlb A G 1: 170,735,168 (GRCm39) S320P probably damaging Het
Fer1l4 T C 2: 155,887,348 (GRCm39) D616G probably benign Het
Fxr2 C T 11: 69,543,095 (GRCm39) R631C possibly damaging Het
Gltpd2 T A 11: 70,410,822 (GRCm39) F152I probably damaging Het
Gpt2 T A 8: 86,242,782 (GRCm39) probably null Het
Hsd3b6 A T 3: 98,713,888 (GRCm39) I137K possibly damaging Het
Kcna6 A G 6: 126,715,917 (GRCm39) V324A probably benign Het
Kcnu1 C T 8: 26,422,298 (GRCm39) L188F probably damaging Het
Kdm1b A G 13: 47,221,982 (GRCm39) I474V possibly damaging Het
Kifap3 C T 1: 163,693,013 (GRCm39) Q602* probably null Het
Lrp4 T A 2: 91,305,065 (GRCm39) C231S possibly damaging Het
Lrrc63 T C 14: 75,323,640 (GRCm39) D528G probably benign Het
Nosip C A 7: 44,726,156 (GRCm39) R240S possibly damaging Het
Or11g26 T C 14: 50,752,900 (GRCm39) S80P probably damaging Het
Or4f57 G A 2: 111,790,603 (GRCm39) P272S probably benign Het
Or4k41 A G 2: 111,279,695 (GRCm39) D70G probably damaging Het
Orc5 A T 5: 22,731,438 (GRCm39) D231E probably damaging Het
Poli A T 18: 70,659,645 (GRCm39) M62K possibly damaging Het
Ppp1r13b A C 12: 111,801,477 (GRCm39) S402R probably damaging Het
Ptpra T C 2: 130,382,393 (GRCm39) probably benign Het
Sfpq T A 4: 126,919,929 (GRCm39) probably null Het
Sh3bp1 T A 15: 78,790,088 (GRCm39) probably benign Het
Slc7a2 T G 8: 41,352,048 (GRCm39) V37G probably damaging Het
Smc1a A T X: 150,820,655 (GRCm39) E794D possibly damaging Het
Sox6 T C 7: 115,149,274 (GRCm39) R366G possibly damaging Het
Spaca7 A G 8: 12,636,498 (GRCm39) N108S possibly damaging Het
Spon1 T G 7: 113,365,567 (GRCm39) M1R probably null Het
Sult6b2 T C 6: 142,747,498 (GRCm39) R84G probably benign Het
Syt2 A G 1: 134,673,553 (GRCm39) N299S probably benign Het
Syvn1 T C 19: 6,098,570 (GRCm39) V104A probably damaging Het
Tbpl1 A G 10: 22,583,568 (GRCm39) L134P probably damaging Het
Tex11 A T X: 99,920,135 (GRCm39) probably benign Het
Tnfrsf21 A G 17: 43,350,942 (GRCm39) S369G probably damaging Het
Tram1l1 T C 3: 124,115,707 (GRCm39) V289A probably benign Het
Ttyh3 A T 5: 140,619,060 (GRCm39) F277L probably benign Het
Vmn2r17 T G 5: 109,582,247 (GRCm39) N545K probably damaging Het
Wdr20 A T 12: 110,759,657 (GRCm39) H181L probably benign Het
Zscan20 A G 4: 128,498,392 (GRCm39) M2T possibly damaging Het
Other mutations in Prl3b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02669:Prl3b1 APN 13 27,429,795 (GRCm39) missense probably benign 0.24
IGL03035:Prl3b1 APN 13 27,433,516 (GRCm39) unclassified probably benign
IGL03077:Prl3b1 APN 13 27,429,759 (GRCm39) missense probably benign 0.00
Gabby UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
peaches UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
Pits UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R2014_Prl3b1_632 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R0716:Prl3b1 UTSW 13 27,427,779 (GRCm39) missense probably benign 0.02
R0758:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0773:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0774:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0775:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1364:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1366:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1367:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1368:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1530:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1884:Prl3b1 UTSW 13 27,431,886 (GRCm39) missense possibly damaging 0.95
R1990:Prl3b1 UTSW 13 27,429,775 (GRCm39) missense possibly damaging 0.94
R1991:Prl3b1 UTSW 13 27,431,895 (GRCm39) missense possibly damaging 0.60
R2014:Prl3b1 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R2885:Prl3b1 UTSW 13 27,433,505 (GRCm39) missense probably damaging 1.00
R4259:Prl3b1 UTSW 13 27,427,889 (GRCm39) splice site probably null
R4580:Prl3b1 UTSW 13 27,433,450 (GRCm39) missense possibly damaging 0.93
R4913:Prl3b1 UTSW 13 27,433,460 (GRCm39) missense probably damaging 0.99
R5897:Prl3b1 UTSW 13 27,429,858 (GRCm39) missense probably benign 0.08
R6235:Prl3b1 UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
R6366:Prl3b1 UTSW 13 27,427,875 (GRCm39) missense probably benign 0.00
R6597:Prl3b1 UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R7179:Prl3b1 UTSW 13 27,427,827 (GRCm39) missense probably benign 0.05
R7312:Prl3b1 UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
X0026:Prl3b1 UTSW 13 27,431,906 (GRCm39) missense probably benign 0.21
Z1177:Prl3b1 UTSW 13 27,427,742 (GRCm39) missense probably benign 0.23
Posted On 2015-04-16