Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02385:Tex11'

291529

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex11

Ensembl Gene

ENSMUSG00000009670

Gene Name

testis expressed gene 11

Synonyms

4930565P14Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.237) question?

Stock #

IGL02385

Quality Score

Status

Chromosome

Chromosomal Location

99882254-100103245 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 99920135 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000109347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000009814] [ENSMUST00000113716] [ENSMUST00000113718]

AlphaFold

Q14AT2

Predicted Effect

probably benign
Transcript: ENSMUST00000009814

SMART Domains

Protein: ENSMUSP00000009814
Gene: ENSMUSG00000009670

Domain	Start	End	E-Value	Type
Pfam:SPO22	176	431	1.1e-62	PFAM
low complexity region	702	713	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000113716

SMART Domains

Protein: ENSMUSP00000109345
Gene: ENSMUSG00000009670

Domain	Start	End	E-Value	Type
Pfam:SPO22	175	433	2.1e-70	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000113718

SMART Domains

Protein: ENSMUSP00000109347
Gene: ENSMUSG00000009670

Domain	Start	End	E-Value	Type
Pfam:SPO22	175	433	3.8e-70	PFAM
low complexity region	702	713	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Miche homozygous for a knockout allele exhibit abnormal male meiosis. Mice homozygous for a conditional knockout exhibit male infertility and reduced female fecundity due to abnormal meiosis following cre recombination. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	A	12: 71,201,630 (GRCm39)	D351E	probably damaging	Het
Adad2	A	G	8: 120,341,773 (GRCm39)		probably benign	Het
Adamts8	A	G	9: 30,873,026 (GRCm39)	N744D	probably benign	Het
Atad5	C	T	11: 79,985,453 (GRCm39)	T180I	probably benign	Het
Atp2a3	C	A	11: 72,866,165 (GRCm39)	H262N	probably benign	Het
Bcl9	A	T	3: 97,116,594 (GRCm39)	I700K	probably benign	Het
Bcr	T	C	10: 74,981,235 (GRCm39)	S685P	probably damaging	Het
Cd36	A	G	5: 18,019,717 (GRCm39)	V128A	probably benign	Het
Cfap20dc	A	G	14: 8,510,920 (GRCm38)	V498A	possibly damaging	Het
Chd2	T	C	7: 73,085,570 (GRCm39)	Y1688C	probably damaging	Het
Csmd1	A	G	8: 15,953,275 (GRCm39)	V3402A	probably benign	Het
Dsg3	T	C	18: 20,660,771 (GRCm39)	V370A	probably damaging	Het
Dus4l	A	G	12: 31,690,674 (GRCm39)		probably benign	Het
Fcrlb	A	G	1: 170,735,168 (GRCm39)	S320P	probably damaging	Het
Fer1l4	T	C	2: 155,887,348 (GRCm39)	D616G	probably benign	Het
Fxr2	C	T	11: 69,543,095 (GRCm39)	R631C	possibly damaging	Het
Gltpd2	T	A	11: 70,410,822 (GRCm39)	F152I	probably damaging	Het
Gpt2	T	A	8: 86,242,782 (GRCm39)		probably null	Het
Hsd3b6	A	T	3: 98,713,888 (GRCm39)	I137K	possibly damaging	Het
Kcna6	A	G	6: 126,715,917 (GRCm39)	V324A	probably benign	Het
Kcnu1	C	T	8: 26,422,298 (GRCm39)	L188F	probably damaging	Het
Kdm1b	A	G	13: 47,221,982 (GRCm39)	I474V	possibly damaging	Het
Kifap3	C	T	1: 163,693,013 (GRCm39)	Q602*	probably null	Het
Lrp4	T	A	2: 91,305,065 (GRCm39)	C231S	possibly damaging	Het
Lrrc63	T	C	14: 75,323,640 (GRCm39)	D528G	probably benign	Het
Nosip	C	A	7: 44,726,156 (GRCm39)	R240S	possibly damaging	Het
Or11g26	T	C	14: 50,752,900 (GRCm39)	S80P	probably damaging	Het
Or4f57	G	A	2: 111,790,603 (GRCm39)	P272S	probably benign	Het
Or4k41	A	G	2: 111,279,695 (GRCm39)	D70G	probably damaging	Het
Orc5	A	T	5: 22,731,438 (GRCm39)	D231E	probably damaging	Het
Poli	A	T	18: 70,659,645 (GRCm39)	M62K	possibly damaging	Het
Ppp1r13b	A	C	12: 111,801,477 (GRCm39)	S402R	probably damaging	Het
Prl3b1	T	C	13: 27,433,366 (GRCm39)	S174P	possibly damaging	Het
Ptpra	T	C	2: 130,382,393 (GRCm39)		probably benign	Het
Sfpq	T	A	4: 126,919,929 (GRCm39)		probably null	Het
Sh3bp1	T	A	15: 78,790,088 (GRCm39)		probably benign	Het
Slc7a2	T	G	8: 41,352,048 (GRCm39)	V37G	probably damaging	Het
Smc1a	A	T	X: 150,820,655 (GRCm39)	E794D	possibly damaging	Het
Sox6	T	C	7: 115,149,274 (GRCm39)	R366G	possibly damaging	Het
Spaca7	A	G	8: 12,636,498 (GRCm39)	N108S	possibly damaging	Het
Spon1	T	G	7: 113,365,567 (GRCm39)	M1R	probably null	Het
Sult6b2	T	C	6: 142,747,498 (GRCm39)	R84G	probably benign	Het
Syt2	A	G	1: 134,673,553 (GRCm39)	N299S	probably benign	Het
Syvn1	T	C	19: 6,098,570 (GRCm39)	V104A	probably damaging	Het
Tbpl1	A	G	10: 22,583,568 (GRCm39)	L134P	probably damaging	Het
Tnfrsf21	A	G	17: 43,350,942 (GRCm39)	S369G	probably damaging	Het
Tram1l1	T	C	3: 124,115,707 (GRCm39)	V289A	probably benign	Het
Ttyh3	A	T	5: 140,619,060 (GRCm39)	F277L	probably benign	Het
Vmn2r17	T	G	5: 109,582,247 (GRCm39)	N545K	probably damaging	Het
Wdr20	A	T	12: 110,759,657 (GRCm39)	H181L	probably benign	Het
Zscan20	A	G	4: 128,498,392 (GRCm39)	M2T	possibly damaging	Het

Other mutations in Tex11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00536:Tex11	APN	X	100,076,165 (GRCm39)	missense	probably null	0.00
IGL00838:Tex11	APN	X	100,015,724 (GRCm39)	missense	possibly damaging	0.92
R2958:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R2960:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R2963:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R3008:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R3009:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R3010:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R3011:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R3745:Tex11	UTSW	X	99,960,178 (GRCm39)	missense	probably benign	0.33
R3881:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R3882:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4081:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4082:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4159:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4172:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4197:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4201:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4204:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4206:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4304:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R4305:Tex11	UTSW	X	99,977,021 (GRCm39)	missense	possibly damaging	0.70
R8726:Tex11	UTSW	X	100,059,191 (GRCm39)	missense	possibly damaging	0.82
R8727:Tex11	UTSW	X	100,059,191 (GRCm39)	missense	possibly damaging	0.82

Posted On

2015-04-16