Incidental Mutation 'IGL02387:Trim29'
| ID |
291601 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Trim29
|
| Ensembl Gene |
ENSMUSG00000032013 |
| Gene Name |
tripartite motif-containing 29 |
| Synonyms |
4732461M22Rik, 1110047J21Rik, 2810431N19Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02387
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
43222145-43247412 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 43236149 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Isoleucine
at position 460
(N460I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000034511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034511]
|
| AlphaFold |
Q8R2Q0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034511
AA Change: N460I
PolyPhen 2
Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000034511
Gene: ENSMUSG00000032013
AA Change: N460I
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:BBOX
|
168 |
216 |
3e-25 |
BLAST |
|
BBOX
|
220 |
260 |
1.93e-11 |
SMART |
|
low complexity region
|
399 |
410 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000217067
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000217418
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
A |
G |
11: 109,969,641 (GRCm39) |
|
probably benign |
Het |
| Acap3 |
T |
G |
4: 155,986,617 (GRCm39) |
L311R |
probably damaging |
Het |
| Actr6 |
T |
A |
10: 89,550,846 (GRCm39) |
N316I |
probably damaging |
Het |
| Adarb2 |
T |
A |
13: 8,619,994 (GRCm39) |
V160E |
probably damaging |
Het |
| Atm |
A |
T |
9: 53,391,066 (GRCm39) |
|
probably null |
Het |
| Atp2b4 |
T |
C |
1: 133,659,627 (GRCm39) |
N445S |
probably damaging |
Het |
| Clic6 |
A |
G |
16: 92,326,807 (GRCm39) |
D464G |
probably damaging |
Het |
| Clk2 |
C |
T |
3: 89,083,698 (GRCm39) |
|
probably benign |
Het |
| Cyp4f40 |
A |
C |
17: 32,886,984 (GRCm39) |
T152P |
probably damaging |
Het |
| Dpp8 |
A |
T |
9: 64,952,998 (GRCm39) |
I225F |
probably damaging |
Het |
| Dspp |
A |
G |
5: 104,323,490 (GRCm39) |
Q211R |
possibly damaging |
Het |
| Gja1 |
T |
A |
10: 56,263,902 (GRCm39) |
V87E |
possibly damaging |
Het |
| Gm8165 |
T |
C |
14: 43,913,696 (GRCm39) |
E56G |
possibly damaging |
Het |
| Gstp2 |
T |
A |
19: 4,091,094 (GRCm39) |
|
probably benign |
Het |
| Gucy2e |
A |
G |
11: 69,126,942 (GRCm39) |
V177A |
probably benign |
Het |
| Insrr |
G |
A |
3: 87,720,434 (GRCm39) |
R1024H |
probably damaging |
Het |
| Iqgap2 |
A |
G |
13: 95,826,209 (GRCm39) |
W538R |
probably benign |
Het |
| Lrrc71 |
T |
C |
3: 87,650,378 (GRCm39) |
I232V |
probably damaging |
Het |
| Mphosph8 |
T |
A |
14: 56,933,178 (GRCm39) |
N808K |
probably damaging |
Het |
| Or8h10 |
T |
A |
2: 86,808,193 (GRCm39) |
R316* |
probably null |
Het |
| Pak6 |
T |
C |
2: 118,523,714 (GRCm39) |
S290P |
probably benign |
Het |
| Ptpro |
C |
T |
6: 137,387,978 (GRCm39) |
A734V |
probably damaging |
Het |
| Reg1 |
A |
T |
6: 78,404,321 (GRCm39) |
N65I |
probably damaging |
Het |
| Rnf17 |
T |
G |
14: 56,738,044 (GRCm39) |
I1275S |
probably damaging |
Het |
| Sfrp5 |
C |
T |
19: 42,187,468 (GRCm39) |
V201I |
probably benign |
Het |
| Sgsm1 |
T |
A |
5: 113,400,929 (GRCm39) |
H987L |
possibly damaging |
Het |
| Shank1 |
A |
T |
7: 44,006,361 (GRCm39) |
Y2026F |
possibly damaging |
Het |
| Slc15a2 |
T |
C |
16: 36,572,137 (GRCm39) |
|
probably null |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| Taar8a |
T |
A |
10: 23,953,260 (GRCm39) |
I288N |
possibly damaging |
Het |
| Tpbpb |
T |
G |
13: 61,049,668 (GRCm39) |
*121C |
probably null |
Het |
| Trp53tg5 |
T |
A |
2: 164,313,376 (GRCm39) |
I100F |
possibly damaging |
Het |
| Ubr2 |
T |
C |
17: 47,274,076 (GRCm39) |
T871A |
probably benign |
Het |
| Vrk1 |
A |
G |
12: 106,036,803 (GRCm39) |
E363G |
probably damaging |
Het |
| Zfyve19 |
C |
T |
2: 119,046,907 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Trim29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02364:Trim29
|
APN |
9 |
43,222,599 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1770:Trim29
|
UTSW |
9 |
43,243,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1883:Trim29
|
UTSW |
9 |
43,222,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1962:Trim29
|
UTSW |
9 |
43,222,615 (GRCm39) |
missense |
probably benign |
|
|
R4198:Trim29
|
UTSW |
9 |
43,222,677 (GRCm39) |
nonsense |
probably null |
|
|
R4200:Trim29
|
UTSW |
9 |
43,222,677 (GRCm39) |
nonsense |
probably null |
|
|
R4303:Trim29
|
UTSW |
9 |
43,222,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4863:Trim29
|
UTSW |
9 |
43,240,872 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4934:Trim29
|
UTSW |
9 |
43,222,265 (GRCm39) |
missense |
probably benign |
0.36 |
|
R6171:Trim29
|
UTSW |
9 |
43,230,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6737:Trim29
|
UTSW |
9 |
43,230,681 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6972:Trim29
|
UTSW |
9 |
43,238,409 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7191:Trim29
|
UTSW |
9 |
43,222,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7434:Trim29
|
UTSW |
9 |
43,246,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7588:Trim29
|
UTSW |
9 |
43,246,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7590:Trim29
|
UTSW |
9 |
43,222,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8781:Trim29
|
UTSW |
9 |
43,222,615 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8866:Trim29
|
UTSW |
9 |
43,222,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8922:Trim29
|
UTSW |
9 |
43,233,636 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9336:Trim29
|
UTSW |
9 |
43,238,350 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9709:Trim29
|
UTSW |
9 |
43,231,797 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trim29
|
UTSW |
9 |
43,233,621 (GRCm39) |
missense |
probably benign |
0.06 |
|
| Posted On |
2015-04-16 |
Incidental Mutation