Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02389:Vmn1r34'

291659

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r34

Ensembl Gene

ENSMUSG00000091012

Gene Name

vomeronasal 1 receptor 34

Synonyms

Gm5991

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02389

Quality Score

Status

Chromosome

Chromosomal Location

66613807-66614736 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 66614042 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 232 (L232Q)

Ref Sequence

ENSEMBL: ENSMUSP00000153720 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074381] [ENSMUST00000226262] [ENSMUST00000226910] [ENSMUST00000226999] [ENSMUST00000227332] [ENSMUST00000228498] [ENSMUST00000228647]

AlphaFold

G3XA52

Predicted Effect

probably damaging
Transcript: ENSMUST00000074381
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000132900
Gene: ENSMUSG00000091012
AA Change: L232Q

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	2.2e-54	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000226262
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226910
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000226999
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000227332
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228498
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228647
AA Change: L232Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610040J01Rik	G	A	5: 64,053,826 (GRCm39)	S11N	probably null	Het
Aqp9	T	C	9: 71,030,188 (GRCm39)	I200V	possibly damaging	Het
Cntn2	T	C	1: 132,453,059 (GRCm39)	E411G	probably damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cstdc5	C	A	16: 36,187,848 (GRCm39)	V6F	possibly damaging	Het
Dennd3	A	G	15: 73,438,905 (GRCm39)	D1091G	probably damaging	Het
Dock2	T	C	11: 34,589,567 (GRCm39)		probably benign	Het
Dscam	T	A	16: 96,442,097 (GRCm39)	I1577F	probably benign	Het
Egflam	A	T	15: 7,279,559 (GRCm39)	N482K	probably benign	Het
Fam216a	T	C	5: 122,505,574 (GRCm39)	T129A	probably damaging	Het
Fbxo40	T	C	16: 36,790,136 (GRCm39)	M325V	probably benign	Het
Fbxw8	C	T	5: 118,267,020 (GRCm39)	V148M	possibly damaging	Het
Fcgbp	C	T	7: 27,774,596 (GRCm39)	R57C	probably damaging	Het
Gnpnat1	A	G	14: 45,618,388 (GRCm39)		probably null	Het
Gria2	T	C	3: 80,616,729 (GRCm39)	T408A	probably benign	Het
H2-T3	A	G	17: 36,497,500 (GRCm39)	M59T	probably benign	Het
Jakmip1	C	T	5: 37,258,187 (GRCm39)	Q278*	probably null	Het
Krtap21-1	C	T	16: 89,200,312 (GRCm39)	G110D	unknown	Het
Myo7a	C	T	7: 97,756,198 (GRCm39)		probably null	Het
Nlrp9c	T	A	7: 26,093,632 (GRCm39)	Q11L	probably benign	Het
Or14a257	A	G	7: 86,138,336 (GRCm39)	L141P	probably damaging	Het
Or5b94	A	T	19: 12,651,899 (GRCm39)	D110V	probably benign	Het
Or6c75	T	A	10: 129,336,939 (GRCm39)	M62K	probably benign	Het
Or6c8	A	C	10: 128,915,099 (GRCm39)	I244M	probably damaging	Het
Pdzd8	A	G	19: 59,289,825 (GRCm39)	I525T	probably benign	Het
Pign	A	T	1: 105,574,506 (GRCm39)	L280*	probably null	Het
Pik3r4	T	G	9: 105,527,530 (GRCm39)	I294M	possibly damaging	Het
Pkhd1	T	A	1: 20,187,944 (GRCm39)	I3455F	probably damaging	Het
Prmt3	C	T	7: 49,498,506 (GRCm39)	Q471*	probably null	Het
Prrc2c	A	G	1: 162,520,439 (GRCm39)	F2006L	probably damaging	Het
Ptger3	C	T	3: 157,272,808 (GRCm39)	R52C	probably damaging	Het
Rfx2	T	C	17: 57,115,325 (GRCm39)		probably benign	Het
Sh3bp4	T	C	1: 89,072,870 (GRCm39)	F573L	probably damaging	Het
Slc18a2	G	T	19: 59,251,733 (GRCm39)		probably benign	Het
Slc26a8	T	A	17: 28,857,624 (GRCm39)	I840F	probably benign	Het
Slc5a4b	A	T	10: 75,908,299 (GRCm39)	Y364*	probably null	Het
Slitrk1	A	G	14: 109,149,754 (GRCm39)	I319T	probably benign	Het
Stxbp5l	C	T	16: 37,028,567 (GRCm39)	A499T	probably benign	Het
Tnks2	T	A	19: 36,861,503 (GRCm39)	S951R	probably benign	Het
Trim30c	A	G	7: 104,031,381 (GRCm39)	F478S	probably benign	Het
Tyro3	C	T	2: 119,635,345 (GRCm39)		probably benign	Het
Zfp148	T	A	16: 33,315,816 (GRCm39)	C215S	probably damaging	Het
Zzef1	C	T	11: 72,782,043 (GRCm39)	P1995S	probably benign	Het
Zzef1	T	A	11: 72,790,364 (GRCm39)	V2106D	possibly damaging	Het

Other mutations in Vmn1r34

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00974:Vmn1r34	APN	6	66,614,639 (GRCm39)	missense	possibly damaging	0.64
IGL01322:Vmn1r34	APN	6	66,613,899 (GRCm39)	nonsense	probably null
IGL01866:Vmn1r34	APN	6	66,614,373 (GRCm39)	missense	probably benign	0.03
IGL03356:Vmn1r34	APN	6	66,613,970 (GRCm39)	missense	probably benign	0.00
R0508:Vmn1r34	UTSW	6	66,614,392 (GRCm39)	missense	probably benign	0.19
R0601:Vmn1r34	UTSW	6	66,614,648 (GRCm39)	missense	possibly damaging	0.94
R1381:Vmn1r34	UTSW	6	66,613,922 (GRCm39)	missense	probably damaging	1.00
R1605:Vmn1r34	UTSW	6	66,613,932 (GRCm39)	missense	probably benign	0.01
R1765:Vmn1r34	UTSW	6	66,614,480 (GRCm39)	missense	probably damaging	0.99
R2022:Vmn1r34	UTSW	6	66,614,385 (GRCm39)	missense	possibly damaging	0.90
R3878:Vmn1r34	UTSW	6	66,614,552 (GRCm39)	missense	possibly damaging	0.82
R4023:Vmn1r34	UTSW	6	66,614,688 (GRCm39)	missense	probably benign
R4024:Vmn1r34	UTSW	6	66,614,688 (GRCm39)	missense	probably benign
R4025:Vmn1r34	UTSW	6	66,614,688 (GRCm39)	missense	probably benign
R4026:Vmn1r34	UTSW	6	66,614,688 (GRCm39)	missense	probably benign
R4385:Vmn1r34	UTSW	6	66,614,123 (GRCm39)	missense	probably damaging	0.99
R5274:Vmn1r34	UTSW	6	66,614,123 (GRCm39)	missense	probably damaging	1.00
R6182:Vmn1r34	UTSW	6	66,614,312 (GRCm39)	missense	probably damaging	0.97
R6629:Vmn1r34	UTSW	6	66,614,499 (GRCm39)	missense	probably benign	0.00
R7143:Vmn1r34	UTSW	6	66,614,648 (GRCm39)	missense	probably benign	0.12
R7689:Vmn1r34	UTSW	6	66,613,994 (GRCm39)	nonsense	probably null
R7956:Vmn1r34	UTSW	6	66,614,777 (GRCm39)	start gained	probably benign
R8031:Vmn1r34	UTSW	6	66,614,165 (GRCm39)	missense	probably damaging	1.00
R9570:Vmn1r34	UTSW	6	66,614,718 (GRCm39)	missense	probably benign	0.00
X0066:Vmn1r34	UTSW	6	66,614,459 (GRCm39)	missense	probably benign	0.02
Z1176:Vmn1r34	UTSW	6	66,614,109 (GRCm39)	nonsense	probably null

Posted On

2015-04-16