Incidental Mutation 'IGL02401:Vsig10l'
ID 291887
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vsig10l
Ensembl Gene ENSMUSG00000070604
Gene Name V-set and immunoglobulin domain containing 10 like
Synonyms 2210412E05Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.204) question?
Stock # IGL02401
Quality Score
Status
Chromosome 7
Chromosomal Location 43112575-43121443 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 43113468 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 140 (L140Q)
Ref Sequence ENSEMBL: ENSMUSP00000144692 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107977] [ENSMUST00000203042] [ENSMUST00000203633] [ENSMUST00000203769] [ENSMUST00000204680]
AlphaFold D3YZF7
Predicted Effect possibly damaging
Transcript: ENSMUST00000107977
AA Change: L242Q

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000103611
Gene: ENSMUSG00000070604
AA Change: L242Q

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 28 52 N/A INTRINSIC
IG 183 285 1.92e0 SMART
IG 298 383 2.15e-3 SMART
IGc2 406 465 4.19e-6 SMART
Blast:IG_like 582 649 1e-13 BLAST
transmembrane domain 764 786 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000203042
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203152
Predicted Effect probably benign
Transcript: ENSMUST00000203633
SMART Domains Protein: ENSMUSP00000145061
Gene: ENSMUSG00000107482

DomainStartEndE-ValueType
ETF 26 216 2.7e-65 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000203769
AA Change: L140Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144692
Gene: ENSMUSG00000070604
AA Change: L140Q

DomainStartEndE-ValueType
IG 81 183 8.1e-3 SMART
IG 196 281 9.2e-6 SMART
IGc2 304 363 1.8e-8 SMART
Blast:IG_like 480 547 9e-14 BLAST
transmembrane domain 662 684 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000204680
SMART Domains Protein: ENSMUSP00000145493
Gene: ENSMUSG00000107482

DomainStartEndE-ValueType
ETF 26 168 2.4e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205247
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef18 C T 8: 3,487,078 (GRCm39) R266C probably damaging Het
Asb11 A T X: 163,241,753 (GRCm39) probably benign Het
Cnot1 G A 8: 96,482,761 (GRCm39) T764M possibly damaging Het
Galns A G 8: 123,331,938 (GRCm39) M59T probably damaging Het
Gm5884 A G 6: 128,622,377 (GRCm39) noncoding transcript Het
Gm9312 A C 12: 24,302,106 (GRCm39) noncoding transcript Het
Lama3 T C 18: 12,690,784 (GRCm39) F1268S probably benign Het
Lrp5 A G 19: 3,643,585 (GRCm39) C1347R probably damaging Het
Lrrfip1 T C 1: 91,042,650 (GRCm39) S352P probably benign Het
Mcfd2 T C 17: 87,564,592 (GRCm39) T97A probably damaging Het
Mroh2b A G 15: 4,929,983 (GRCm39) N23S possibly damaging Het
Nr1i3 A T 1: 171,043,942 (GRCm39) probably benign Het
Or4c10b T C 2: 89,711,797 (GRCm39) F209S probably damaging Het
Or8b48 C T 9: 38,492,651 (GRCm39) P26L probably damaging Het
Orm2 A C 4: 63,281,568 (GRCm39) I100L probably benign Het
Pbsn A G X: 76,886,129 (GRCm39) M126T probably benign Het
Rpgr G T X: 10,024,956 (GRCm39) T1026K possibly damaging Het
Sdhaf3 C T 6: 7,038,855 (GRCm39) T59M probably benign Het
Shq1 T C 6: 100,625,208 (GRCm39) Y217C probably damaging Het
Slc17a8 A T 10: 89,412,522 (GRCm39) probably null Het
Slc6a19 A G 13: 73,848,709 (GRCm39) I15T probably damaging Het
Smarcd3 A T 5: 24,798,717 (GRCm39) V335E probably damaging Het
Sugp2 A G 8: 70,695,821 (GRCm39) T265A possibly damaging Het
Tfrc T G 16: 32,435,999 (GRCm39) S225R probably damaging Het
Zbtb46 T A 2: 181,065,245 (GRCm39) T302S probably benign Het
Znhit1 T C 5: 137,011,513 (GRCm39) Y105C probably damaging Het
Other mutations in Vsig10l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01319:Vsig10l APN 7 43,114,678 (GRCm39) missense probably damaging 1.00
IGL01390:Vsig10l APN 7 43,115,889 (GRCm39) missense probably damaging 0.97
IGL02404:Vsig10l APN 7 43,113,171 (GRCm39) missense possibly damaging 0.85
IGL02514:Vsig10l APN 7 43,113,338 (GRCm39) missense probably benign 0.02
IGL02636:Vsig10l APN 7 43,113,002 (GRCm39) missense possibly damaging 0.53
IGL02805:Vsig10l APN 7 43,114,666 (GRCm39) missense probably damaging 1.00
IGL02823:Vsig10l APN 7 43,115,888 (GRCm39) missense probably damaging 1.00
IGL02827:Vsig10l APN 7 43,114,293 (GRCm39) missense probably damaging 1.00
R0111:Vsig10l UTSW 7 43,117,525 (GRCm39) missense probably damaging 0.97
R0394:Vsig10l UTSW 7 43,114,879 (GRCm39) missense probably damaging 0.97
R0465:Vsig10l UTSW 7 43,116,866 (GRCm39) missense probably damaging 1.00
R0632:Vsig10l UTSW 7 43,113,561 (GRCm39) missense probably damaging 0.97
R1689:Vsig10l UTSW 7 43,114,792 (GRCm39) missense possibly damaging 0.93
R1991:Vsig10l UTSW 7 43,116,892 (GRCm39) missense possibly damaging 0.89
R2103:Vsig10l UTSW 7 43,116,892 (GRCm39) missense possibly damaging 0.89
R2358:Vsig10l UTSW 7 43,118,185 (GRCm39) missense probably benign 0.00
R3015:Vsig10l UTSW 7 43,116,881 (GRCm39) missense possibly damaging 0.73
R4024:Vsig10l UTSW 7 43,117,510 (GRCm39) missense probably benign 0.33
R4031:Vsig10l UTSW 7 43,114,798 (GRCm39) missense probably damaging 1.00
R4807:Vsig10l UTSW 7 43,113,173 (GRCm39) missense possibly damaging 0.53
R5020:Vsig10l UTSW 7 43,114,741 (GRCm39) nonsense probably null
R5261:Vsig10l UTSW 7 43,120,274 (GRCm39) missense probably damaging 1.00
R5317:Vsig10l UTSW 7 43,114,247 (GRCm39) missense probably damaging 1.00
R5426:Vsig10l UTSW 7 43,114,247 (GRCm39) missense probably damaging 0.97
R5656:Vsig10l UTSW 7 43,113,575 (GRCm39) nonsense probably null
R5842:Vsig10l UTSW 7 43,118,396 (GRCm39) missense probably benign 0.15
R6012:Vsig10l UTSW 7 43,117,439 (GRCm39) missense probably damaging 1.00
R6235:Vsig10l UTSW 7 43,118,396 (GRCm39) missense probably benign 0.15
R6309:Vsig10l UTSW 7 43,120,397 (GRCm39) splice site probably null
R6994:Vsig10l UTSW 7 43,114,491 (GRCm39) missense possibly damaging 0.71
R7250:Vsig10l UTSW 7 43,113,099 (GRCm39) missense probably benign
R7397:Vsig10l UTSW 7 43,117,431 (GRCm39) missense probably damaging 1.00
R7767:Vsig10l UTSW 7 43,113,141 (GRCm39) missense probably damaging 0.96
R7956:Vsig10l UTSW 7 43,117,494 (GRCm39) missense probably benign
R8086:Vsig10l UTSW 7 43,114,876 (GRCm39) missense possibly damaging 0.92
R8139:Vsig10l UTSW 7 43,113,153 (GRCm39) missense probably benign 0.00
R8297:Vsig10l UTSW 7 43,113,531 (GRCm39) missense possibly damaging 0.50
R8341:Vsig10l UTSW 7 43,113,378 (GRCm39) missense probably damaging 1.00
R8519:Vsig10l UTSW 7 43,114,326 (GRCm39) missense probably benign 0.33
R8925:Vsig10l UTSW 7 43,116,020 (GRCm39) missense probably benign 0.41
R8927:Vsig10l UTSW 7 43,116,020 (GRCm39) missense probably benign 0.41
R8948:Vsig10l UTSW 7 43,117,623 (GRCm39) missense possibly damaging 0.53
R9157:Vsig10l UTSW 7 43,112,948 (GRCm39) missense
R9203:Vsig10l UTSW 7 43,112,657 (GRCm39) start codon destroyed probably null
R9481:Vsig10l UTSW 7 43,112,795 (GRCm39) nonsense probably null
X0028:Vsig10l UTSW 7 43,112,788 (GRCm39) utr 3 prime probably benign
X0067:Vsig10l UTSW 7 43,116,914 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16