Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02404:Rps4l'

291994

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rps4l

Ensembl Gene

ENSMUSG00000063171

Gene Name

ribosomal protein S4-like

Synonyms

1110033J19Rik, Rps4y2

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL02404

Quality Score

Status

Chromosome

Chromosomal Location

148256154-148257094 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 148256277 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000115543 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060095] [ENSMUST00000100772] [ENSMUST00000140797]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000060095

SMART Domains

Protein: ENSMUSP00000056353
Gene: ENSMUSG00000030306

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
transmembrane domain	111	130	N/A	INTRINSIC
transmembrane domain	142	164	N/A	INTRINSIC
low complexity region	170	180	N/A	INTRINSIC
transmembrane domain	195	217	N/A	INTRINSIC
low complexity region	250	269	N/A	INTRINSIC
transmembrane domain	328	350	N/A	INTRINSIC
Pfam:DUF1736	351	425	1.3e-33	PFAM
transmembrane domain	444	466	N/A	INTRINSIC
transmembrane domain	494	516	N/A	INTRINSIC
TPR	543	576	2.42e-3	SMART
TPR	577	607	8.76e-1	SMART
TPR	608	641	1.69e-2	SMART
TPR	642	675	1.28e-2	SMART
TPR	676	709	4.31e0	SMART
TPR	710	743	1.11e-2	SMART
TPR	744	776	4.62e0	SMART
TPR	811	844	1.1e-1	SMART
TPR	849	882	4.45e-2	SMART
TPR	883	916	1.05e-3	SMART
low complexity region	926	941	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000071745

SMART Domains

Protein: ENSMUSP00000071658
Gene: ENSMUSG00000063171

Domain	Start	End	E-Value	Type
Pfam:RS4NT	3	39	4.3e-24	PFAM
S4	42	106	1.23e-5	SMART
Pfam:KOW	177	211	4.3e-8	PFAM
Pfam:40S_S4_C	212	259	1e-32	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000100772

SMART Domains

Protein: ENSMUSP00000098335
Gene: ENSMUSG00000030306

Domain	Start	End	E-Value	Type
transmembrane domain	21	43	N/A	INTRINSIC
transmembrane domain	111	130	N/A	INTRINSIC
transmembrane domain	142	164	N/A	INTRINSIC
low complexity region	170	180	N/A	INTRINSIC
transmembrane domain	195	217	N/A	INTRINSIC
low complexity region	250	269	N/A	INTRINSIC
Pfam:DUF1736	349	427	6.9e-35	PFAM
transmembrane domain	444	466	N/A	INTRINSIC
transmembrane domain	494	516	N/A	INTRINSIC
TPR	539	569	8.76e-1	SMART
TPR	570	603	1.69e-2	SMART
TPR	604	637	1.28e-2	SMART
TPR	638	671	4.31e0	SMART
TPR	672	705	1.11e-2	SMART
TPR	706	738	4.62e0	SMART
TPR	773	806	1.1e-1	SMART
TPR	811	844	4.45e-2	SMART
TPR	845	878	1.05e-3	SMART
low complexity region	888	903	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000140797

SMART Domains

Protein: ENSMUSP00000115543
Gene: ENSMUSG00000030306

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
transmembrane domain	69	91	N/A	INTRINSIC
transmembrane domain	112	134	N/A	INTRINSIC
low complexity region	160	179	N/A	INTRINSIC
Pfam:DUF1736	259	337	9.9e-36	PFAM
transmembrane domain	357	379	N/A	INTRINSIC
transmembrane domain	403	425	N/A	INTRINSIC
Pfam:TPR_12	449	516	9.6e-10	PFAM
Pfam:TPR_11	451	498	1.3e-9	PFAM
Pfam:TPR_1	453	486	5.7e-6	PFAM
Pfam:TPR_2	453	486	2.6e-7	PFAM
Pfam:TPR_8	453	486	6.5e-4	PFAM
Pfam:TPR_1	487	517	1.6e-3	PFAM
Pfam:TPR_8	496	518	1.5e-3	PFAM
low complexity region	521	539	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204242

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204618

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy6	T	C	15: 98,494,819 (GRCm39)	I745V	probably benign	Het
Alppl2	A	G	1: 87,016,585 (GRCm39)	V163A	possibly damaging	Het
Atad2b	T	A	12: 4,991,972 (GRCm39)	S190R	probably benign	Het
Cep68	A	G	11: 20,190,004 (GRCm39)	V336A	possibly damaging	Het
Clcn4	A	C	7: 7,290,857 (GRCm39)	N587K	probably benign	Het
Clic1	A	G	17: 35,271,852 (GRCm39)	E82G	probably damaging	Het
Cnbd1	T	C	4: 18,895,047 (GRCm39)	S232G	possibly damaging	Het
Cplane1	T	C	15: 8,216,768 (GRCm39)	I662T	possibly damaging	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Daw1	A	G	1: 83,174,952 (GRCm39)	T151A	probably benign	Het
Dysf	A	G	6: 84,093,043 (GRCm39)	E1052G	probably damaging	Het
Gpr12	G	A	5: 146,520,733 (GRCm39)	A63V	probably damaging	Het
Inmt	C	T	6: 55,148,095 (GRCm39)	R178Q	possibly damaging	Het
Metap1	A	T	3: 138,195,069 (GRCm39)	C22S	probably damaging	Het
Mst1r	A	T	9: 107,790,266 (GRCm39)		probably benign	Het
Or2ag17	A	C	7: 106,389,566 (GRCm39)	I214S	probably damaging	Het
Phkb	T	C	8: 86,604,744 (GRCm39)	S58P	possibly damaging	Het
Pigs	T	A	11: 78,230,857 (GRCm39)	I368N	probably benign	Het
Plekhm1	C	T	11: 103,285,824 (GRCm39)	D204N	probably benign	Het
Pot1a	A	T	6: 25,764,431 (GRCm39)		probably benign	Het
Scn8a	T	A	15: 100,937,611 (GRCm39)	M1660K	probably damaging	Het
Sec31b	A	C	19: 44,523,227 (GRCm39)	V23G	probably damaging	Het
Sorcs3	T	C	19: 48,692,809 (GRCm39)		probably benign	Het
Thap12	A	G	7: 98,359,340 (GRCm39)	Y73C	probably damaging	Het
Thsd7b	G	A	1: 129,540,888 (GRCm39)	C254Y	probably damaging	Het
Tmem214	G	A	5: 31,030,090 (GRCm39)	A296T	probably benign	Het
Ttn	T	A	2: 76,770,322 (GRCm39)	N2623I	possibly damaging	Het
Ulk1	A	T	5: 110,944,100 (GRCm39)		probably null	Het
Vps13d	T	C	4: 144,875,305 (GRCm39)	Y1734C	probably damaging	Het
Vsig10l	A	G	7: 43,113,171 (GRCm39)	D143G	possibly damaging	Het
Wac	A	G	18: 7,917,570 (GRCm39)	T347A	probably damaging	Het
Wdr62	G	T	7: 29,967,298 (GRCm39)	R319S	probably damaging	Het
Zfp668	T	C	7: 127,465,532 (GRCm39)	K551E	probably damaging	Het

Other mutations in Rps4l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Rps4l	APN	6	148,256,383 (GRCm39)	intron	probably benign

Posted On

2015-04-16