Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00985:Retnlg'

29208

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Retnlg

Ensembl Gene

ENSMUSG00000022651

Gene Name

resistin like gamma

Synonyms

Xcp1, Fizz3, Relmg

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL00985

Quality Score

Status

Chromosome

Chromosomal Location

48692984-48694859 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 48694688 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 112 (R112H)

Ref Sequence

ENSEMBL: ENSMUSP00000070238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065666]

AlphaFold

Q8K426

Predicted Effect

possibly damaging
Transcript: ENSMUST00000065666
AA Change: R112H

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000070238
Gene: ENSMUSG00000022651
AA Change: R112H

Domain	Start	End	E-Value	Type
low complexity region	9	21	N/A	INTRINSIC
Pfam:Resistin	29	116	1.6e-38	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630091E08Rik	G	T	7: 98,193,125 (GRCm39)		noncoding transcript	Het
Abca15	G	A	7: 119,996,241 (GRCm39)	G1389E	probably damaging	Het
Adcy3	T	C	12: 4,184,600 (GRCm39)	V92A	probably damaging	Het
Aoc1l1	A	G	6: 48,954,481 (GRCm39)	S540G	probably benign	Het
Aplnr	A	T	2: 84,968,007 (GRCm39)	Y344F	probably benign	Het
Atm	A	T	9: 53,371,116 (GRCm39)	V2241E	probably damaging	Het
Cep290	T	C	10: 100,403,023 (GRCm39)		probably benign	Het
Cnpy1	A	T	5: 28,414,152 (GRCm39)	Y91*	probably null	Het
Cobl	C	A	11: 12,204,843 (GRCm39)	G613W	probably damaging	Het
Csn1s2a	T	C	5: 87,932,439 (GRCm39)	S121P	possibly damaging	Het
Flg2	A	T	3: 93,110,585 (GRCm39)	Y871F	unknown	Het
Gapvd1	T	A	2: 34,585,575 (GRCm39)	D1008V	probably damaging	Het
Gask1a	T	C	9: 121,807,401 (GRCm39)	L515P	probably damaging	Het
Igfl3	T	C	7: 17,914,000 (GRCm39)		probably null	Het
Kmt2b	A	T	7: 30,279,352 (GRCm39)	V1470E	probably damaging	Het
Mcc	A	T	18: 44,624,306 (GRCm39)	L413Q	probably damaging	Het
Mia2	G	A	12: 59,235,146 (GRCm39)	G610D	probably damaging	Het
Mlst8	A	T	17: 24,696,287 (GRCm39)	D147E	probably damaging	Het
Muc19	G	T	15: 91,770,943 (GRCm39)		noncoding transcript	Het
Mybpc3	A	G	2: 90,965,704 (GRCm39)	E1172G	probably benign	Het
Niban3	T	C	8: 72,057,507 (GRCm39)		probably benign	Het
Nop14	A	T	5: 34,802,133 (GRCm39)	L557Q	probably damaging	Het
P3h3	T	C	6: 124,822,552 (GRCm39)	T540A	probably benign	Het
Phc3	T	A	3: 30,968,346 (GRCm39)	I897F	probably benign	Het
Plekhh2	G	A	17: 84,871,356 (GRCm39)	V205I	probably benign	Het
Poc5	A	G	13: 96,547,254 (GRCm39)	K506E	probably damaging	Het
Pum1	C	A	4: 130,471,100 (GRCm39)	T450K	probably damaging	Het
Rgl2	T	C	17: 34,151,075 (GRCm39)	V101A	probably damaging	Het
Serinc5	A	G	13: 92,842,779 (GRCm39)	T410A	probably damaging	Het
Shroom1	T	C	11: 53,356,796 (GRCm39)	V553A	probably benign	Het
Slco4c1	A	T	1: 96,768,912 (GRCm39)	W317R	probably damaging	Het
Snap91	T	C	9: 86,703,790 (GRCm39)	T268A	probably benign	Het
Supt16	T	C	14: 52,399,148 (GRCm39)	K1044E	possibly damaging	Het
Tarbp1	A	T	8: 127,185,900 (GRCm39)	L431I	probably damaging	Het
Tas2r124	C	T	6: 132,732,492 (GRCm39)	T267I	probably benign	Het
Tm7sf3	C	T	6: 146,507,692 (GRCm39)	V457I	possibly damaging	Het
Tmem132c	A	T	5: 127,581,930 (GRCm39)	S382C	probably damaging	Het
Tmprss7	C	A	16: 45,482,685 (GRCm39)	C582F	probably damaging	Het
Tsc2	T	C	17: 24,816,105 (GRCm39)	E1694G	probably damaging	Het
Txndc2	G	T	17: 65,945,544 (GRCm39)	S211Y	possibly damaging	Het
Ubr3	A	C	2: 69,833,775 (GRCm39)	T205P	probably damaging	Het
Vmn2r116	G	A	17: 23,620,489 (GRCm39)	G741D	probably damaging	Het
Vps8	G	A	16: 21,296,334 (GRCm39)		probably benign	Het
Wdr19	G	A	5: 65,409,642 (GRCm39)	D1127N	probably benign	Het
Zim1	T	A	7: 6,685,759 (GRCm39)	Y83F	possibly damaging	Het

Other mutations in Retnlg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02500:Retnlg	APN	16	48,693,323 (GRCm39)	missense	probably benign	0.16
IGL02588:Retnlg	APN	16	48,693,255 (GRCm39)	missense	probably benign	0.07
IGL03206:Retnlg	APN	16	48,694,655 (GRCm39)	missense	probably damaging	1.00
R1165:Retnlg	UTSW	16	48,694,017 (GRCm39)	missense	possibly damaging	0.76
R1751:Retnlg	UTSW	16	48,693,991 (GRCm39)	missense	possibly damaging	0.54
R1767:Retnlg	UTSW	16	48,693,991 (GRCm39)	missense	possibly damaging	0.54
R1796:Retnlg	UTSW	16	48,694,610 (GRCm39)	missense	probably benign	0.06
R2037:Retnlg	UTSW	16	48,694,615 (GRCm39)	missense	probably damaging	1.00
R4780:Retnlg	UTSW	16	48,694,697 (GRCm39)	missense	possibly damaging	0.74
R7298:Retnlg	UTSW	16	48,693,237 (GRCm39)	missense	probably benign
R7983:Retnlg	UTSW	16	48,693,261 (GRCm39)	missense	probably damaging	0.98
R8991:Retnlg	UTSW	16	48,694,038 (GRCm39)	missense	possibly damaging	0.50
R9140:Retnlg	UTSW	16	48,693,288 (GRCm39)	missense	possibly damaging	0.85

Posted On

2013-04-17