Incidental Mutation 'IGL02408:Npff'
ID 292189
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Npff
Ensembl Gene ENSMUSG00000023052
Gene Name neuropeptide FF-amide peptide precursor
Synonyms
Accession Numbers
Essential gene? Not available question?
Stock # IGL02408
Quality Score
Status
Chromosome 15
Chromosomal Location 102432274-102433056 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 102433000 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 15 (L15Q)
Ref Sequence ENSEMBL: ENSMUSP00000023814 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023813] [ENSMUST00000023814] [ENSMUST00000096143] [ENSMUST00000100168] [ENSMUST00000131184] [ENSMUST00000184772] [ENSMUST00000146756] [ENSMUST00000149200] [ENSMUST00000142194] [ENSMUST00000184616] [ENSMUST00000150393] [ENSMUST00000184906] [ENSMUST00000229805]
AlphaFold Q9WVA8
Predicted Effect probably benign
Transcript: ENSMUST00000023813
SMART Domains Protein: ENSMUSP00000023813
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
DSRM 31 96 6.65e-25 SMART
low complexity region 105 121 N/A INTRINSIC
low complexity region 123 137 N/A INTRINSIC
DSRM 159 225 9.21e-19 SMART
DSRM 293 359 9.35e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000023814
AA Change: L15Q

PolyPhen 2 Score 0.699 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000023814
Gene: ENSMUSG00000023052
AA Change: L15Q

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:NPFF 24 114 3.1e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000096143
Predicted Effect probably benign
Transcript: ENSMUST00000100168
SMART Domains Protein: ENSMUSP00000097744
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
low complexity region 16 28 N/A INTRINSIC
low complexity region 32 46 N/A INTRINSIC
DSRM 68 134 9.21e-19 SMART
DSRM 202 268 9.35e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131184
SMART Domains Protein: ENSMUSP00000117964
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
DSRM 31 77 1.45e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134033
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141266
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154451
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136968
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184659
Predicted Effect probably benign
Transcript: ENSMUST00000154948
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153171
Predicted Effect probably benign
Transcript: ENSMUST00000184772
SMART Domains Protein: ENSMUSP00000138975
Gene: ENSMUSG00000052414

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146756
SMART Domains Protein: ENSMUSP00000121748
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
DSRM 10 75 6.65e-25 SMART
low complexity region 84 100 N/A INTRINSIC
low complexity region 102 116 N/A INTRINSIC
DSRM 138 204 9.21e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149200
SMART Domains Protein: ENSMUSP00000123213
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
DSRM 10 56 1.45e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000142194
SMART Domains Protein: ENSMUSP00000123339
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
DSRM 10 75 6.65e-25 SMART
low complexity region 84 100 N/A INTRINSIC
low complexity region 102 116 N/A INTRINSIC
DSRM 138 204 9.21e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000184616
SMART Domains Protein: ENSMUSP00000139181
Gene: ENSMUSG00000099083

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000150393
SMART Domains Protein: ENSMUSP00000120315
Gene: ENSMUSG00000023051

DomainStartEndE-ValueType
low complexity region 6 22 N/A INTRINSIC
low complexity region 24 38 N/A INTRINSIC
PDB:2CPN|A 50 89 1e-22 PDB
Blast:DSRM 60 89 2e-14 BLAST
SCOP:d1di2a_ 60 89 2e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000184906
SMART Domains Protein: ENSMUSP00000139243
Gene: ENSMUSG00000099083

DomainStartEndE-ValueType
ZnF_C2H2 7 31 6.32e-3 SMART
low complexity region 108 130 N/A INTRINSIC
low complexity region 228 244 N/A INTRINSIC
low complexity region 300 318 N/A INTRINSIC
low complexity region 319 326 N/A INTRINSIC
BRLZ 330 394 3.46e-18 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000229805
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes neuropeptides involved in analgesia, cardiovascular regulation, neuroendocrine function and opiate addiction. The encoded protein is a preproprotein that undergoes further processing to generate multiple amidated peptides. [provided by RefSeq, Jul 2015]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,621,130 (GRCm39) Y278C probably damaging Het
Abcd2 A G 15: 91,062,444 (GRCm39) L498P possibly damaging Het
Acot11 A G 4: 106,615,578 (GRCm39) F271S probably damaging Het
Acr T A 15: 89,454,217 (GRCm39) Y185N probably damaging Het
Adcy10 C T 1: 165,365,949 (GRCm39) R489C probably damaging Het
Arsb A G 13: 93,930,670 (GRCm39) T213A probably benign Het
Atg2a T A 19: 6,291,858 (GRCm39) C11* probably null Het
B3galt6 A T 4: 156,076,152 (GRCm39) Y308N probably damaging Het
Cd226 A G 18: 89,225,451 (GRCm39) N116S probably benign Het
Crat T A 2: 30,297,146 (GRCm39) D269V probably damaging Het
Crim1 T A 17: 78,623,083 (GRCm39) I427N possibly damaging Het
Dock3 T C 9: 106,790,298 (GRCm39) probably benign Het
Dsg1c T A 18: 20,407,776 (GRCm39) V374E probably damaging Het
Dtl A G 1: 191,273,352 (GRCm39) S519P probably benign Het
Fastkd1 C T 2: 69,532,945 (GRCm39) R474H probably benign Het
Fbxo10 T C 4: 45,058,361 (GRCm39) T459A possibly damaging Het
Frmd4b A G 6: 97,272,770 (GRCm39) L828P probably damaging Het
Gc T C 5: 89,593,255 (GRCm39) S55G probably benign Het
Gm6455 T G 5: 10,917,257 (GRCm39) noncoding transcript Het
Gnai2 T C 9: 107,493,393 (GRCm39) T280A probably benign Het
Hmgn2 A G 4: 133,693,260 (GRCm39) probably null Het
Jmjd1c G T 10: 67,062,161 (GRCm39) A1505S probably benign Het
Lrriq1 T C 10: 102,982,142 (GRCm39) K1393E probably benign Het
Mcam A G 9: 44,051,547 (GRCm39) N469D probably benign Het
Mrpl47 A G 3: 32,790,789 (GRCm39) probably null Het
Mslnl C T 17: 25,966,972 (GRCm39) A659V possibly damaging Het
Nlrp1a A G 11: 71,013,456 (GRCm39) V598A probably benign Het
Obsl1 G T 1: 75,481,890 (GRCm39) Q327K probably damaging Het
Or13a18 T C 7: 140,190,844 (GRCm39) V255A probably damaging Het
Or4c58 T A 2: 89,675,315 (GRCm39) M1L probably benign Het
Or52s1b T C 7: 102,822,658 (GRCm39) Y62C probably damaging Het
Or7e165 A T 9: 19,694,711 (GRCm39) Y94F probably benign Het
Or8b50 G A 9: 38,518,417 (GRCm39) G219S possibly damaging Het
Pdzd2 T A 15: 12,375,851 (GRCm39) H1428L probably benign Het
Phldb1 T C 9: 44,627,203 (GRCm39) E414G possibly damaging Het
Reln T C 5: 22,106,617 (GRCm39) D3251G probably benign Het
Secisbp2l G T 2: 125,582,789 (GRCm39) S889* probably null Het
Setx T A 2: 29,023,942 (GRCm39) C133S probably damaging Het
Slc22a29 A C 19: 8,184,649 (GRCm39) S214A probably benign Het
Slc30a5 A C 13: 100,950,232 (GRCm39) L285R probably damaging Het
Taar7a T G 10: 23,868,500 (GRCm39) I294L probably benign Het
Tfap2b T A 1: 19,304,485 (GRCm39) F414I probably damaging Het
Trpc4ap A T 2: 155,512,989 (GRCm39) Y129N possibly damaging Het
Vmn2r94 T C 17: 18,473,523 (GRCm39) E501G probably benign Het
Xpot T C 10: 121,439,070 (GRCm39) H709R probably damaging Het
Zfhx3 T A 8: 109,682,004 (GRCm39) probably benign Het
Zscan22 T G 7: 12,640,426 (GRCm39) H223Q probably benign Het
Posted On 2015-04-16