Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02409:Vmn2r45'

292209

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r45

Ensembl Gene

ENSMUSG00000090662

Gene Name

vomeronasal 2, receptor 45

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02409

Quality Score

Status

Chromosome

Chromosomal Location

8474468-8491958 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 8488727 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 101 (Y101C)

Ref Sequence

ENSEMBL: ENSMUSP00000129466 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164845]

AlphaFold

L7N2B5

Predicted Effect

probably benign
Transcript: ENSMUST00000164845
AA Change: Y101C

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: Y101C

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	154	469	4.5e-26	PFAM
Pfam:NCD3G	512	565	6.4e-21	PFAM
Pfam:7tm_3	598	833	2.1e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aqp4	T	A	18: 15,532,782 (GRCm39)	M104L	probably benign	Het
Cdkn1a	T	C	17: 29,317,428 (GRCm39)	V16A	probably benign	Het
Celsr2	C	A	3: 108,321,271 (GRCm39)	V514F	probably damaging	Het
Cmklr2	T	A	1: 63,222,875 (GRCm39)	N120I	probably damaging	Het
Cmya5	T	C	13: 93,226,706 (GRCm39)	N2794S	probably damaging	Het
Dnmt1	T	C	9: 20,837,793 (GRCm39)	T281A	probably benign	Het
Dock2	A	T	11: 34,451,204 (GRCm39)	N840K	probably benign	Het
Dscam	T	C	16: 96,621,088 (GRCm39)	N540S	possibly damaging	Het
Elavl1	A	T	8: 4,339,838 (GRCm39)	I248N	possibly damaging	Het
Fam120a	A	G	13: 49,120,835 (GRCm39)	V157A	probably benign	Het
Fcrl2	G	A	3: 87,160,030 (GRCm39)	P408L	probably benign	Het
Grin2b	T	A	6: 136,020,906 (GRCm39)	M132L	possibly damaging	Het
Herc2	T	A	7: 55,870,217 (GRCm39)		probably null	Het
Lrp1b	T	G	2: 41,335,208 (GRCm39)	K778T	possibly damaging	Het
Mapk10	T	A	5: 103,076,096 (GRCm39)	E389D	possibly damaging	Het
Ms4a7	G	T	19: 11,301,807 (GRCm39)	Y62*	probably null	Het
Muc5b	A	G	7: 141,415,075 (GRCm39)	T2674A	possibly damaging	Het
Nbeal1	T	C	1: 60,368,494 (GRCm39)	L2613P	probably benign	Het
Ncapg2	A	T	12: 116,384,337 (GRCm39)	Y266F	probably damaging	Het
Or10a3m	A	G	7: 108,313,366 (GRCm39)	I269V	probably benign	Het
Or14j6	T	C	17: 38,214,679 (GRCm39)	Y81H	probably damaging	Het
Or1j14	T	A	2: 36,418,165 (GRCm39)	V247E	probably damaging	Het
Or4c110	C	T	2: 88,832,254 (GRCm39)	C126Y	possibly damaging	Het
Pkd1	T	A	17: 24,792,597 (GRCm39)	I1428N	probably benign	Het
Ppil4	T	C	10: 7,674,328 (GRCm39)		probably benign	Het
Rev3l	T	C	10: 39,697,144 (GRCm39)	V547A	possibly damaging	Het
Rgsl1	T	C	1: 153,701,989 (GRCm39)	K155R	possibly damaging	Het
Skap2	T	C	6: 51,884,938 (GRCm39)	D234G	possibly damaging	Het
Sult2a4	C	T	7: 13,718,844 (GRCm39)	W133*	probably null	Het
Tbc1d2b	C	T	9: 90,104,405 (GRCm39)	S579N	probably benign	Het
Tdrkh	T	A	3: 94,337,919 (GRCm39)		probably benign	Het
Thumpd2	A	T	17: 81,340,117 (GRCm39)	F377L	probably damaging	Het
Tmem132d	T	C	5: 127,861,952 (GRCm39)	D723G	probably damaging	Het
Tnfrsf23	A	T	7: 143,222,308 (GRCm39)	L168Q	probably damaging	Het
Ttn	T	C	2: 76,784,974 (GRCm39)	T818A	unknown	Het
Uox	A	T	3: 146,330,381 (GRCm39)	D130V	probably benign	Het
Wdr1	C	T	5: 38,688,453 (GRCm39)	D161N	probably benign	Het

Other mutations in Vmn2r45

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Vmn2r45	APN	7	8,488,622 (GRCm39)	missense	probably benign	0.00
IGL01322:Vmn2r45	APN	7	8,484,332 (GRCm39)	missense	possibly damaging	0.49
IGL01402:Vmn2r45	APN	7	8,484,467 (GRCm39)	missense	probably damaging	0.98
IGL01404:Vmn2r45	APN	7	8,484,467 (GRCm39)	missense	probably damaging	0.98
IGL01529:Vmn2r45	APN	7	8,486,493 (GRCm39)	missense	probably benign
IGL01596:Vmn2r45	APN	7	8,486,272 (GRCm39)	missense	probably damaging	0.98
IGL01646:Vmn2r45	APN	7	8,486,337 (GRCm39)	missense	probably benign	0.18
IGL01819:Vmn2r45	APN	7	8,488,556 (GRCm39)	missense	probably benign	0.00
IGL02096:Vmn2r45	APN	7	8,484,443 (GRCm39)	missense	probably damaging	0.99
IGL02130:Vmn2r45	APN	7	8,486,556 (GRCm39)	missense	possibly damaging	0.46
IGL02517:Vmn2r45	APN	7	8,486,185 (GRCm39)	nonsense	probably null
IGL02633:Vmn2r45	APN	7	8,488,728 (GRCm39)	missense	probably benign	0.01
IGL02940:Vmn2r45	APN	7	8,475,369 (GRCm39)	missense	probably damaging	0.99
IGL03281:Vmn2r45	APN	7	8,486,603 (GRCm39)	missense	probably damaging	1.00
IGL03358:Vmn2r45	APN	7	8,474,715 (GRCm39)	missense	probably damaging	1.00
BB004:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
BB014:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
R0382:Vmn2r45	UTSW	7	8,486,098 (GRCm39)	missense	probably benign	0.06
R0532:Vmn2r45	UTSW	7	8,474,820 (GRCm39)	missense	probably damaging	0.99
R0932:Vmn2r45	UTSW	7	8,478,380 (GRCm39)	missense	probably damaging	1.00
R1125:Vmn2r45	UTSW	7	8,488,542 (GRCm39)	missense	probably benign	0.00
R1580:Vmn2r45	UTSW	7	8,474,746 (GRCm39)	missense	possibly damaging	0.95
R1817:Vmn2r45	UTSW	7	8,475,372 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r45	UTSW	7	8,475,024 (GRCm39)	missense	probably damaging	1.00
R2050:Vmn2r45	UTSW	7	8,475,021 (GRCm39)	missense	probably damaging	1.00
R2284:Vmn2r45	UTSW	7	8,488,765 (GRCm39)	missense	probably benign	0.02
R4019:Vmn2r45	UTSW	7	8,474,580 (GRCm39)	nonsense	probably null
R4227:Vmn2r45	UTSW	7	8,486,277 (GRCm39)	missense	probably damaging	0.98
R4381:Vmn2r45	UTSW	7	8,474,912 (GRCm39)	nonsense	probably null
R4618:Vmn2r45	UTSW	7	8,486,436 (GRCm39)	missense	probably benign	0.00
R4624:Vmn2r45	UTSW	7	8,484,341 (GRCm39)	missense	probably damaging	1.00
R4704:Vmn2r45	UTSW	7	8,486,535 (GRCm39)	nonsense	probably null
R4735:Vmn2r45	UTSW	7	8,486,472 (GRCm39)	missense	probably damaging	1.00
R4868:Vmn2r45	UTSW	7	8,484,480 (GRCm39)	missense	probably benign	0.06
R4983:Vmn2r45	UTSW	7	8,486,116 (GRCm39)	missense	probably damaging	0.99
R5246:Vmn2r45	UTSW	7	8,486,251 (GRCm39)	missense	probably benign	0.00
R5430:Vmn2r45	UTSW	7	8,486,333 (GRCm39)	nonsense	probably null
R5504:Vmn2r45	UTSW	7	8,486,176 (GRCm39)	missense	probably benign	0.03
R5511:Vmn2r45	UTSW	7	8,474,832 (GRCm39)	missense	probably benign	0.19
R5745:Vmn2r45	UTSW	7	8,486,074 (GRCm39)	missense	probably benign	0.00
R5814:Vmn2r45	UTSW	7	8,474,475 (GRCm39)	missense	probably benign	0.00
R6223:Vmn2r45	UTSW	7	8,486,301 (GRCm39)	missense	probably benign
R6267:Vmn2r45	UTSW	7	8,475,207 (GRCm39)	missense	probably benign	0.26
R6623:Vmn2r45	UTSW	7	8,474,500 (GRCm39)	missense	probably benign	0.09
R6999:Vmn2r45	UTSW	7	8,486,219 (GRCm39)	missense	probably benign
R7242:Vmn2r45	UTSW	7	8,488,612 (GRCm39)	nonsense	probably null
R7491:Vmn2r45	UTSW	7	8,484,342 (GRCm39)	missense	probably benign	0.27
R7620:Vmn2r45	UTSW	7	8,486,222 (GRCm39)	nonsense	probably null
R7719:Vmn2r45	UTSW	7	8,486,460 (GRCm39)	missense	probably damaging	0.99
R7720:Vmn2r45	UTSW	7	8,486,460 (GRCm39)	missense	probably damaging	0.99
R7853:Vmn2r45	UTSW	7	8,485,987 (GRCm39)	missense	possibly damaging	0.90
R7873:Vmn2r45	UTSW	7	8,486,074 (GRCm39)	missense	probably benign	0.00
R7882:Vmn2r45	UTSW	7	8,486,409 (GRCm39)	missense	possibly damaging	0.82
R7927:Vmn2r45	UTSW	7	8,486,513 (GRCm39)	missense	probably benign
R8684:Vmn2r45	UTSW	7	8,486,511 (GRCm39)	missense	probably damaging	0.99
R8780:Vmn2r45	UTSW	7	8,484,371 (GRCm39)	missense	possibly damaging	0.94
R8811:Vmn2r45	UTSW	7	8,474,881 (GRCm39)	missense	probably damaging	1.00
R8893:Vmn2r45	UTSW	7	8,488,619 (GRCm39)	missense	probably damaging	1.00
R9043:Vmn2r45	UTSW	7	8,474,904 (GRCm39)	missense	possibly damaging	0.92
R9208:Vmn2r45	UTSW	7	8,486,298 (GRCm39)	missense	probably damaging	1.00
R9327:Vmn2r45	UTSW	7	8,474,532 (GRCm39)	missense	probably damaging	1.00
R9586:Vmn2r45	UTSW	7	8,486,050 (GRCm39)	missense	probably benign	0.01
R9599:Vmn2r45	UTSW	7	8,478,457 (GRCm39)	critical splice acceptor site	probably null
U24488:Vmn2r45	UTSW	7	8,475,361 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r45	UTSW	7	8,474,484 (GRCm39)	missense	probably benign	0.16

Posted On

2015-04-16