Incidental Mutation 'IGL02414:Gpr85'
ID |
292379 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Gpr85
|
Ensembl Gene |
ENSMUSG00000048216 |
Gene Name |
G protein-coupled receptor 85 |
Synonyms |
2900026B03Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.189)
|
Stock # |
IGL02414
|
Quality Score |
|
Status
|
|
Chromosome |
6 |
Chromosomal Location |
13834457-13839941 bp(-) (GRCm39) |
Type of Mutation |
utr 5 prime |
DNA Base Change (assembly) |
A to T
at 13836909 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000111155
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060442]
[ENSMUST00000115491]
[ENSMUST00000115492]
|
AlphaFold |
P60894 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000060442
|
SMART Domains |
Protein: ENSMUSP00000053837 Gene: ENSMUSG00000048216
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
37 |
338 |
4.1e-38 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115491
|
SMART Domains |
Protein: ENSMUSP00000111154 Gene: ENSMUSG00000048216
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
37 |
338 |
4.1e-38 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000115492
|
SMART Domains |
Protein: ENSMUSP00000111155 Gene: ENSMUSG00000048216
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
37 |
338 |
1.6e-32 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127072
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008] PHENOTYPE: Mice homozygous for a knock-out allele display a significant increase in brain weight and enhanced contextual memory in a fear-conditioning task but no additional behavioral abnormalities. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 24 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ada |
C |
T |
2: 163,571,960 (GRCm39) |
D273N |
probably benign |
Het |
Btbd9 |
A |
C |
17: 30,439,533 (GRCm39) |
C551W |
possibly damaging |
Het |
Casp2 |
T |
A |
6: 42,257,380 (GRCm39) |
L443H |
probably damaging |
Het |
Cdhr3 |
A |
G |
12: 33,092,503 (GRCm39) |
Y703H |
possibly damaging |
Het |
Clta |
T |
C |
4: 44,030,274 (GRCm39) |
|
probably benign |
Het |
Cstdc2 |
T |
G |
2: 148,692,598 (GRCm39) |
K68T |
possibly damaging |
Het |
Dnah8 |
A |
G |
17: 30,919,387 (GRCm39) |
D1120G |
probably benign |
Het |
Ece2 |
A |
G |
16: 20,459,456 (GRCm39) |
D597G |
probably damaging |
Het |
Etfdh |
A |
G |
3: 79,511,403 (GRCm39) |
V526A |
probably damaging |
Het |
Gm14496 |
T |
A |
2: 181,633,198 (GRCm39) |
D60E |
probably benign |
Het |
Hivep1 |
C |
A |
13: 42,308,385 (GRCm39) |
S208R |
probably damaging |
Het |
Kif1b |
A |
G |
4: 149,283,771 (GRCm39) |
I1252T |
probably damaging |
Het |
Knl1 |
T |
C |
2: 118,900,804 (GRCm39) |
V835A |
possibly damaging |
Het |
Or2d4 |
A |
T |
7: 106,543,965 (GRCm39) |
M81K |
probably benign |
Het |
Or5ac25 |
C |
T |
16: 59,182,077 (GRCm39) |
C168Y |
probably damaging |
Het |
Ppwd1 |
T |
G |
13: 104,359,645 (GRCm39) |
I119L |
probably benign |
Het |
Prex1 |
T |
C |
2: 166,451,748 (GRCm39) |
K410R |
probably damaging |
Het |
Prm2 |
C |
T |
16: 10,609,754 (GRCm39) |
|
probably benign |
Het |
Psip1 |
T |
C |
4: 83,386,874 (GRCm39) |
T166A |
probably benign |
Het |
Rtel1 |
T |
C |
2: 180,977,765 (GRCm39) |
V98A |
probably benign |
Het |
Sdsl |
G |
A |
5: 120,600,124 (GRCm39) |
T91I |
probably damaging |
Het |
Tas2r136 |
A |
G |
6: 132,754,494 (GRCm39) |
M211T |
possibly damaging |
Het |
Trim43c |
A |
T |
9: 88,723,885 (GRCm39) |
|
probably null |
Het |
Ttc1 |
T |
C |
11: 43,630,664 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Gpr85 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0784:Gpr85
|
UTSW |
6 |
13,836,748 (GRCm39) |
missense |
probably benign |
0.25 |
R1356:Gpr85
|
UTSW |
6 |
13,836,146 (GRCm39) |
missense |
probably benign |
0.42 |
R2343:Gpr85
|
UTSW |
6 |
13,836,695 (GRCm39) |
missense |
probably damaging |
1.00 |
R3934:Gpr85
|
UTSW |
6 |
13,836,044 (GRCm39) |
missense |
probably benign |
0.02 |
R3935:Gpr85
|
UTSW |
6 |
13,836,044 (GRCm39) |
missense |
probably benign |
0.02 |
R3936:Gpr85
|
UTSW |
6 |
13,836,044 (GRCm39) |
missense |
probably benign |
0.02 |
R4925:Gpr85
|
UTSW |
6 |
13,835,977 (GRCm39) |
missense |
probably benign |
0.26 |
R5313:Gpr85
|
UTSW |
6 |
13,836,301 (GRCm39) |
missense |
probably damaging |
1.00 |
R5586:Gpr85
|
UTSW |
6 |
13,836,000 (GRCm39) |
nonsense |
probably null |
|
R7043:Gpr85
|
UTSW |
6 |
13,835,876 (GRCm39) |
missense |
probably damaging |
1.00 |
R8458:Gpr85
|
UTSW |
6 |
13,836,848 (GRCm39) |
missense |
probably benign |
|
R8468:Gpr85
|
UTSW |
6 |
13,836,295 (GRCm39) |
missense |
probably damaging |
1.00 |
R8503:Gpr85
|
UTSW |
6 |
13,836,829 (GRCm39) |
missense |
probably benign |
0.01 |
R9519:Gpr85
|
UTSW |
6 |
13,836,998 (GRCm39) |
start gained |
probably benign |
|
|
Posted On |
2015-04-16 |