Incidental Mutation 'IGL02419:Ifi205'
ID292572
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi205
Ensembl Gene ENSMUSG00000054203
Gene Nameinterferon activated gene 205
SynonymsD3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.157) question?
Stock #IGL02419
Quality Score
Status
Chromosome1
Chromosomal Location174011998-174031810 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 174017614 bp
ZygosityHeterozygous
Amino Acid Change Alanine to Threonine at position 201 (A201T)
Ref Sequence ENSEMBL: ENSMUSP00000062409 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059226]
Predicted Effect probably damaging
Transcript: ENSMUST00000059226
AA Change: A201T

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000062409
Gene: ENSMUSG00000054203
AA Change: A201T

DomainStartEndE-ValueType
PYRIN 6 84 9.42e-13 SMART
low complexity region 102 112 N/A INTRINSIC
low complexity region 121 134 N/A INTRINSIC
low complexity region 168 185 N/A INTRINSIC
Pfam:HIN 204 372 2e-76 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik T C 8: 87,586,099 F171L possibly damaging Het
Abca2 A G 2: 25,446,837 N2291D probably benign Het
Adamts9 A G 6: 92,796,997 V1145A probably benign Het
Adcy2 A G 13: 68,982,363 V135A probably benign Het
Akr1c14 A T 13: 4,080,617 probably null Het
Aptx G T 4: 40,691,032 A229E probably benign Het
Ash1l T C 3: 88,985,565 S1584P probably benign Het
Catsper3 A T 13: 55,808,068 T329S possibly damaging Het
Cntrl A G 2: 35,134,043 D27G probably damaging Het
Cobll1 A T 2: 65,151,048 I98K probably damaging Het
Ctdp1 T C 18: 80,420,584 K79R probably damaging Het
Cwf19l2 T C 9: 3,418,777 probably null Het
Cyp11b2 A T 15: 74,851,055 F498Y probably damaging Het
Dnpep A G 1: 75,315,688 I162T probably damaging Het
Efcab9 T C 11: 32,522,950 I166V probably benign Het
Ep400 A T 5: 110,697,376 probably null Het
Gata6 G A 18: 11,054,220 G50R probably damaging Het
Gm9631 G A 11: 121,943,652 Het
Grifin T C 5: 140,564,700 T20A probably benign Het
Hnf4a A T 2: 163,566,282 I352F probably damaging Het
Ifi204 T C 1: 173,749,380 T552A possibly damaging Het
Kcnk6 A G 7: 29,225,202 V259A probably benign Het
Kif21b A G 1: 136,151,267 N451S probably benign Het
Klhl24 T A 16: 20,107,368 Y215* probably null Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Mical1 A G 10: 41,482,277 K429E possibly damaging Het
Misp A G 10: 79,827,871 probably benign Het
Mon2 T C 10: 123,016,447 N1007S probably benign Het
Olfr1420 A T 19: 11,896,822 Y267F probably benign Het
Olfr228 T A 2: 86,482,915 I276F probably damaging Het
Olfr307 C A 7: 86,335,662 V245F probably damaging Het
Olfr624 A T 7: 103,670,475 C185* probably null Het
Pex6 C A 17: 46,724,435 T840N possibly damaging Het
Prox1 C T 1: 190,161,130 A373T probably benign Het
Rapgef3 G T 15: 97,750,290 N679K probably benign Het
Serpina3n T C 12: 104,413,518 V390A possibly damaging Het
Sirpb1a A G 3: 15,426,338 F23S probably benign Het
Slc44a3 T C 3: 121,490,257 T449A probably benign Het
Smad6 G A 9: 63,953,518 probably benign Het
Sos2 C T 12: 69,616,990 M573I probably benign Het
St8sia1 A T 6: 142,828,935 I306N probably damaging Het
Tnks1bp1 T C 2: 85,071,781 S1674P possibly damaging Het
Trim47 G A 11: 116,106,201 R576W probably damaging Het
Wdr86 A T 5: 24,722,704 I79N probably damaging Het
Wwp2 T A 8: 107,549,815 V473D probably damaging Het
Zc3h12a T C 4: 125,119,788 T428A probably benign Het
Zfp592 A G 7: 81,038,245 E973G probably damaging Het
Other mutations in Ifi205
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Ifi205 APN 1 174027333 splice site probably benign
IGL02476:Ifi205 APN 1 174015061 missense probably damaging 1.00
IGL03128:Ifi205 APN 1 174015086 missense probably damaging 0.99
IGL03154:Ifi205 APN 1 174017666 splice site probably benign
R0211:Ifi205 UTSW 1 174028428 missense probably benign
R1932:Ifi205 UTSW 1 174028414 missense possibly damaging 0.47
R2397:Ifi205 UTSW 1 174017575 missense possibly damaging 0.64
R3115:Ifi205 UTSW 1 174028335 missense possibly damaging 0.95
R4534:Ifi205 UTSW 1 174017641 missense probably benign 0.16
R4544:Ifi205 UTSW 1 174026573 missense possibly damaging 0.96
R4715:Ifi205 UTSW 1 174028321 missense possibly damaging 0.51
R4977:Ifi205 UTSW 1 174015008 missense probably benign 0.07
R5844:Ifi205 UTSW 1 174026692 splice site probably null
R6061:Ifi205 UTSW 1 174027264 missense possibly damaging 0.91
R6510:Ifi205 UTSW 1 174017565 missense probably damaging 1.00
Posted On2015-04-16