Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02419:Or51v8'

292576

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or51v8

Ensembl Gene

ENSMUSG00000045780

Gene Name

olfactory receptor family 51 subfamily V member 8

Synonyms

Olfr624, MOR4-2P, GA_x6K02T2PBJ9-6394126-6393197

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL02419

Quality Score

Status

Chromosome

Chromosomal Location

103319310-103320236 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 103319682 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 185 (C185*)

Ref Sequence

ENSEMBL: ENSMUSP00000049938 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062144]

AlphaFold

F8VQI7

Predicted Effect

probably null
Transcript: ENSMUST00000062144
AA Change: C185*

SMART Domains

Protein: ENSMUSP00000049938
Gene: ENSMUSG00000045780
AA Change: C185*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	27	306	3.3e-138	PFAM
Pfam:7tm_1	37	288	1.8e-19	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402J07Rik	T	C	8: 88,312,727 (GRCm39)	F171L	possibly damaging	Het
Abca2	A	G	2: 25,336,849 (GRCm39)	N2291D	probably benign	Het
Adamts9	A	G	6: 92,773,978 (GRCm39)	V1145A	probably benign	Het
Adcy2	A	G	13: 69,130,482 (GRCm39)	V135A	probably benign	Het
Akr1c14	A	T	13: 4,130,617 (GRCm39)		probably null	Het
Aptx	G	T	4: 40,691,032 (GRCm39)	A229E	probably benign	Het
Ash1l	T	C	3: 88,892,872 (GRCm39)	S1584P	probably benign	Het
Catsper3	A	T	13: 55,955,881 (GRCm39)	T329S	possibly damaging	Het
Cntrl	A	G	2: 35,024,055 (GRCm39)	D27G	probably damaging	Het
Cobll1	A	T	2: 64,981,392 (GRCm39)	I98K	probably damaging	Het
Ctdp1	T	C	18: 80,463,799 (GRCm39)	K79R	probably damaging	Het
Cwf19l2	T	C	9: 3,418,777 (GRCm39)		probably null	Het
Cyp11b2	A	T	15: 74,722,904 (GRCm39)	F498Y	probably damaging	Het
Dnpep	A	G	1: 75,292,332 (GRCm39)	I162T	probably damaging	Het
Efcab9	T	C	11: 32,472,950 (GRCm39)	I166V	probably benign	Het
Ep400	A	T	5: 110,845,242 (GRCm39)		probably null	Het
Gata6	G	A	18: 11,054,220 (GRCm39)	G50R	probably damaging	Het
Gm9631	G	A	11: 121,834,478 (GRCm39)			Het
Grifin	T	C	5: 140,550,455 (GRCm39)	T20A	probably benign	Het
Hnf4a	A	T	2: 163,408,202 (GRCm39)	I352F	probably damaging	Het
Ifi204	T	C	1: 173,576,946 (GRCm39)	T552A	possibly damaging	Het
Ifi205	C	T	1: 173,845,180 (GRCm39)	A201T	probably damaging	Het
Kcnk6	A	G	7: 28,924,627 (GRCm39)	V259A	probably benign	Het
Kif21b	A	G	1: 136,079,005 (GRCm39)	N451S	probably benign	Het
Klhl24	T	A	16: 19,926,118 (GRCm39)	Y215*	probably null	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Mical1	A	G	10: 41,358,273 (GRCm39)	K429E	possibly damaging	Het
Misp	A	G	10: 79,663,705 (GRCm39)		probably benign	Het
Mon2	T	C	10: 122,852,352 (GRCm39)	N1007S	probably benign	Het
Or10v1	A	T	19: 11,874,186 (GRCm39)	Y267F	probably benign	Het
Or14a260	C	A	7: 85,984,870 (GRCm39)	V245F	probably damaging	Het
Or8k41	T	A	2: 86,313,259 (GRCm39)	I276F	probably damaging	Het
Pex6	C	A	17: 47,035,361 (GRCm39)	T840N	possibly damaging	Het
Prox1	C	T	1: 189,893,327 (GRCm39)	A373T	probably benign	Het
Rapgef3	G	T	15: 97,648,171 (GRCm39)	N679K	probably benign	Het
Serpina3n	T	C	12: 104,379,777 (GRCm39)	V390A	possibly damaging	Het
Sirpb1a	A	G	3: 15,491,398 (GRCm39)	F23S	probably benign	Het
Slc44a3	T	C	3: 121,283,906 (GRCm39)	T449A	probably benign	Het
Smad6	G	A	9: 63,860,800 (GRCm39)		probably benign	Het
Sos2	C	T	12: 69,663,764 (GRCm39)	M573I	probably benign	Het
St8sia1	A	T	6: 142,774,661 (GRCm39)	I306N	probably damaging	Het
Tnks1bp1	T	C	2: 84,902,125 (GRCm39)	S1674P	possibly damaging	Het
Trim47	G	A	11: 115,997,027 (GRCm39)	R576W	probably damaging	Het
Wdr86	A	T	5: 24,927,702 (GRCm39)	I79N	probably damaging	Het
Wwp2	T	A	8: 108,276,447 (GRCm39)	V473D	probably damaging	Het
Zc3h12a	T	C	4: 125,013,581 (GRCm39)	T428A	probably benign	Het
Zfp592	A	G	7: 80,687,993 (GRCm39)	E973G	probably damaging	Het

Other mutations in Or51v8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02536:Or51v8	APN	7	103,320,164 (GRCm39)	missense	possibly damaging	0.78
IGL02684:Or51v8	APN	7	103,319,591 (GRCm39)	missense	probably benign	0.06
FR4548:Or51v8	UTSW	7	103,320,174 (GRCm39)	nonsense	probably null
FR4548:Or51v8	UTSW	7	103,320,167 (GRCm39)	small insertion	probably benign
FR4976:Or51v8	UTSW	7	103,320,173 (GRCm39)	small insertion	probably benign
R0295:Or51v8	UTSW	7	103,319,518 (GRCm39)	missense	probably damaging	1.00
R0518:Or51v8	UTSW	7	103,319,696 (GRCm39)	missense	possibly damaging	0.56
R0521:Or51v8	UTSW	7	103,319,696 (GRCm39)	missense	possibly damaging	0.56
R1352:Or51v8	UTSW	7	103,319,518 (GRCm39)	missense	probably damaging	1.00
R1779:Or51v8	UTSW	7	103,319,845 (GRCm39)	missense	probably benign	0.15
R1878:Or51v8	UTSW	7	103,319,389 (GRCm39)	missense	probably damaging	1.00
R1965:Or51v8	UTSW	7	103,320,103 (GRCm39)	missense	probably damaging	1.00
R2162:Or51v8	UTSW	7	103,320,079 (GRCm39)	missense	possibly damaging	0.95
R2316:Or51v8	UTSW	7	103,319,674 (GRCm39)	missense	probably damaging	0.97
R3792:Or51v8	UTSW	7	103,319,353 (GRCm39)	missense	probably damaging	1.00
R3848:Or51v8	UTSW	7	103,319,908 (GRCm39)	missense	probably damaging	0.99
R4120:Or51v8	UTSW	7	103,320,221 (GRCm39)	missense	probably benign
R4183:Or51v8	UTSW	7	103,320,178 (GRCm39)	missense	possibly damaging	0.87
R4853:Or51v8	UTSW	7	103,320,010 (GRCm39)	missense	probably damaging	1.00
R6351:Or51v8	UTSW	7	103,320,163 (GRCm39)	missense	possibly damaging	0.50
R7717:Or51v8	UTSW	7	103,320,152 (GRCm39)	missense	probably benign
R9091:Or51v8	UTSW	7	103,320,124 (GRCm39)	missense	probably damaging	1.00
R9270:Or51v8	UTSW	7	103,320,124 (GRCm39)	missense	probably damaging	1.00
R9273:Or51v8	UTSW	7	103,319,633 (GRCm39)	missense	probably benign	0.03
R9378:Or51v8	UTSW	7	103,319,389 (GRCm39)	missense	probably damaging	1.00
X0026:Or51v8	UTSW	7	103,319,602 (GRCm39)	missense	probably benign

Posted On

2015-04-16