Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02419:Wdr86'

292579

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wdr86

Ensembl Gene

ENSMUSG00000055235

Gene Name

WD repeat domain 86

Synonyms

2810046M22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL02419

Quality Score

Status

Chromosome

Chromosomal Location

24916736-24935725 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 24927702 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 79 (I79N)

Ref Sequence

ENSEMBL: ENSMUSP00000064785 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068693]

AlphaFold

D3Z757

Predicted Effect

probably damaging
Transcript: ENSMUST00000068693
AA Change: I79N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000064785
Gene: ENSMUSG00000055235
AA Change: I79N

Domain	Start	End	E-Value	Type
WD40	4	43	1.62e-8	SMART
WD40	46	83	3.17e-2	SMART
WD40	86	123	1.9e-5	SMART
WD40	126	179	3e-3	SMART
WD40	182	221	2.78e-7	SMART
WD40	224	261	9.9e-4	SMART
WD40	264	301	1.29e-2	SMART
WD40	304	341	6.28e-6	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142607

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933402J07Rik	T	C	8: 88,312,727 (GRCm39)	F171L	possibly damaging	Het
Abca2	A	G	2: 25,336,849 (GRCm39)	N2291D	probably benign	Het
Adamts9	A	G	6: 92,773,978 (GRCm39)	V1145A	probably benign	Het
Adcy2	A	G	13: 69,130,482 (GRCm39)	V135A	probably benign	Het
Akr1c14	A	T	13: 4,130,617 (GRCm39)		probably null	Het
Aptx	G	T	4: 40,691,032 (GRCm39)	A229E	probably benign	Het
Ash1l	T	C	3: 88,892,872 (GRCm39)	S1584P	probably benign	Het
Catsper3	A	T	13: 55,955,881 (GRCm39)	T329S	possibly damaging	Het
Cntrl	A	G	2: 35,024,055 (GRCm39)	D27G	probably damaging	Het
Cobll1	A	T	2: 64,981,392 (GRCm39)	I98K	probably damaging	Het
Ctdp1	T	C	18: 80,463,799 (GRCm39)	K79R	probably damaging	Het
Cwf19l2	T	C	9: 3,418,777 (GRCm39)		probably null	Het
Cyp11b2	A	T	15: 74,722,904 (GRCm39)	F498Y	probably damaging	Het
Dnpep	A	G	1: 75,292,332 (GRCm39)	I162T	probably damaging	Het
Efcab9	T	C	11: 32,472,950 (GRCm39)	I166V	probably benign	Het
Ep400	A	T	5: 110,845,242 (GRCm39)		probably null	Het
Gata6	G	A	18: 11,054,220 (GRCm39)	G50R	probably damaging	Het
Gm9631	G	A	11: 121,834,478 (GRCm39)			Het
Grifin	T	C	5: 140,550,455 (GRCm39)	T20A	probably benign	Het
Hnf4a	A	T	2: 163,408,202 (GRCm39)	I352F	probably damaging	Het
Ifi204	T	C	1: 173,576,946 (GRCm39)	T552A	possibly damaging	Het
Ifi205	C	T	1: 173,845,180 (GRCm39)	A201T	probably damaging	Het
Kcnk6	A	G	7: 28,924,627 (GRCm39)	V259A	probably benign	Het
Kif21b	A	G	1: 136,079,005 (GRCm39)	N451S	probably benign	Het
Klhl24	T	A	16: 19,926,118 (GRCm39)	Y215*	probably null	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Mical1	A	G	10: 41,358,273 (GRCm39)	K429E	possibly damaging	Het
Misp	A	G	10: 79,663,705 (GRCm39)		probably benign	Het
Mon2	T	C	10: 122,852,352 (GRCm39)	N1007S	probably benign	Het
Or10v1	A	T	19: 11,874,186 (GRCm39)	Y267F	probably benign	Het
Or14a260	C	A	7: 85,984,870 (GRCm39)	V245F	probably damaging	Het
Or51v8	A	T	7: 103,319,682 (GRCm39)	C185*	probably null	Het
Or8k41	T	A	2: 86,313,259 (GRCm39)	I276F	probably damaging	Het
Pex6	C	A	17: 47,035,361 (GRCm39)	T840N	possibly damaging	Het
Prox1	C	T	1: 189,893,327 (GRCm39)	A373T	probably benign	Het
Rapgef3	G	T	15: 97,648,171 (GRCm39)	N679K	probably benign	Het
Serpina3n	T	C	12: 104,379,777 (GRCm39)	V390A	possibly damaging	Het
Sirpb1a	A	G	3: 15,491,398 (GRCm39)	F23S	probably benign	Het
Slc44a3	T	C	3: 121,283,906 (GRCm39)	T449A	probably benign	Het
Smad6	G	A	9: 63,860,800 (GRCm39)		probably benign	Het
Sos2	C	T	12: 69,663,764 (GRCm39)	M573I	probably benign	Het
St8sia1	A	T	6: 142,774,661 (GRCm39)	I306N	probably damaging	Het
Tnks1bp1	T	C	2: 84,902,125 (GRCm39)	S1674P	possibly damaging	Het
Trim47	G	A	11: 115,997,027 (GRCm39)	R576W	probably damaging	Het
Wwp2	T	A	8: 108,276,447 (GRCm39)	V473D	probably damaging	Het
Zc3h12a	T	C	4: 125,013,581 (GRCm39)	T428A	probably benign	Het
Zfp592	A	G	7: 80,687,993 (GRCm39)	E973G	probably damaging	Het

Other mutations in Wdr86

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0412:Wdr86	UTSW	5	24,923,232 (GRCm39)	missense	probably benign	0.01
R0899:Wdr86	UTSW	5	24,923,005 (GRCm39)	missense	probably benign	0.15
R2520:Wdr86	UTSW	5	24,917,573 (GRCm39)	makesense	probably null
R3522:Wdr86	UTSW	5	24,923,305 (GRCm39)	missense	probably benign	0.00
R3686:Wdr86	UTSW	5	24,923,339 (GRCm39)	missense	probably damaging	1.00
R4439:Wdr86	UTSW	5	24,935,235 (GRCm39)	missense	probably damaging	1.00
R4657:Wdr86	UTSW	5	24,923,229 (GRCm39)	missense	probably benign	0.00
R4989:Wdr86	UTSW	5	24,917,843 (GRCm39)	splice site	probably null
R5649:Wdr86	UTSW	5	24,923,085 (GRCm39)	missense	probably benign
R5940:Wdr86	UTSW	5	24,927,660 (GRCm39)	missense	probably damaging	1.00
R6254:Wdr86	UTSW	5	24,923,281 (GRCm39)	missense	probably benign	0.04
R8012:Wdr86	UTSW	5	24,935,177 (GRCm39)	critical splice donor site	probably null
R8395:Wdr86	UTSW	5	24,935,187 (GRCm39)	missense	probably damaging	1.00
R9497:Wdr86	UTSW	5	24,920,538 (GRCm39)	missense	probably benign	0.01
Z1177:Wdr86	UTSW	5	24,917,746 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16