Incidental Mutation 'IGL02419:Wdr86'
ID292579
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr86
Ensembl Gene ENSMUSG00000055235
Gene NameWD repeat domain 86
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.138) question?
Stock #IGL02419
Quality Score
Status
Chromosome5
Chromosomal Location24711738-24730727 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 24722704 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 79 (I79N)
Ref Sequence ENSEMBL: ENSMUSP00000064785 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068693]
Predicted Effect probably damaging
Transcript: ENSMUST00000068693
AA Change: I79N

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000064785
Gene: ENSMUSG00000055235
AA Change: I79N

DomainStartEndE-ValueType
WD40 4 43 1.62e-8 SMART
WD40 46 83 3.17e-2 SMART
WD40 86 123 1.9e-5 SMART
WD40 126 179 3e-3 SMART
WD40 182 221 2.78e-7 SMART
WD40 224 261 9.9e-4 SMART
WD40 264 301 1.29e-2 SMART
WD40 304 341 6.28e-6 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142607
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik T C 8: 87,586,099 F171L possibly damaging Het
Abca2 A G 2: 25,446,837 N2291D probably benign Het
Adamts9 A G 6: 92,796,997 V1145A probably benign Het
Adcy2 A G 13: 68,982,363 V135A probably benign Het
Akr1c14 A T 13: 4,080,617 probably null Het
Aptx G T 4: 40,691,032 A229E probably benign Het
Ash1l T C 3: 88,985,565 S1584P probably benign Het
Catsper3 A T 13: 55,808,068 T329S possibly damaging Het
Cntrl A G 2: 35,134,043 D27G probably damaging Het
Cobll1 A T 2: 65,151,048 I98K probably damaging Het
Ctdp1 T C 18: 80,420,584 K79R probably damaging Het
Cwf19l2 T C 9: 3,418,777 probably null Het
Cyp11b2 A T 15: 74,851,055 F498Y probably damaging Het
Dnpep A G 1: 75,315,688 I162T probably damaging Het
Efcab9 T C 11: 32,522,950 I166V probably benign Het
Ep400 A T 5: 110,697,376 probably null Het
Gata6 G A 18: 11,054,220 G50R probably damaging Het
Gm9631 G A 11: 121,943,652 Het
Grifin T C 5: 140,564,700 T20A probably benign Het
Hnf4a A T 2: 163,566,282 I352F probably damaging Het
Ifi204 T C 1: 173,749,380 T552A possibly damaging Het
Ifi205 C T 1: 174,017,614 A201T probably damaging Het
Kcnk6 A G 7: 29,225,202 V259A probably benign Het
Kif21b A G 1: 136,151,267 N451S probably benign Het
Klhl24 T A 16: 20,107,368 Y215* probably null Het
Lyst G A 13: 13,660,956 C1741Y probably benign Het
Mical1 A G 10: 41,482,277 K429E possibly damaging Het
Misp A G 10: 79,827,871 probably benign Het
Mon2 T C 10: 123,016,447 N1007S probably benign Het
Olfr1420 A T 19: 11,896,822 Y267F probably benign Het
Olfr228 T A 2: 86,482,915 I276F probably damaging Het
Olfr307 C A 7: 86,335,662 V245F probably damaging Het
Olfr624 A T 7: 103,670,475 C185* probably null Het
Pex6 C A 17: 46,724,435 T840N possibly damaging Het
Prox1 C T 1: 190,161,130 A373T probably benign Het
Rapgef3 G T 15: 97,750,290 N679K probably benign Het
Serpina3n T C 12: 104,413,518 V390A possibly damaging Het
Sirpb1a A G 3: 15,426,338 F23S probably benign Het
Slc44a3 T C 3: 121,490,257 T449A probably benign Het
Smad6 G A 9: 63,953,518 probably benign Het
Sos2 C T 12: 69,616,990 M573I probably benign Het
St8sia1 A T 6: 142,828,935 I306N probably damaging Het
Tnks1bp1 T C 2: 85,071,781 S1674P possibly damaging Het
Trim47 G A 11: 116,106,201 R576W probably damaging Het
Wwp2 T A 8: 107,549,815 V473D probably damaging Het
Zc3h12a T C 4: 125,119,788 T428A probably benign Het
Zfp592 A G 7: 81,038,245 E973G probably damaging Het
Other mutations in Wdr86
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0412:Wdr86 UTSW 5 24718234 missense probably benign 0.01
R0899:Wdr86 UTSW 5 24718007 missense probably benign 0.15
R2520:Wdr86 UTSW 5 24712575 makesense probably null
R3522:Wdr86 UTSW 5 24718307 missense probably benign 0.00
R3686:Wdr86 UTSW 5 24718341 missense probably damaging 1.00
R4439:Wdr86 UTSW 5 24730237 missense probably damaging 1.00
R4657:Wdr86 UTSW 5 24718231 missense probably benign 0.00
R4989:Wdr86 UTSW 5 24712845 splice site probably null
R5649:Wdr86 UTSW 5 24718087 missense probably benign
R5940:Wdr86 UTSW 5 24722662 missense probably damaging 1.00
R6254:Wdr86 UTSW 5 24718283 missense probably benign 0.04
Posted On2015-04-16