Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02420:Or2r11'

292625

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2r11

Ensembl Gene

ENSMUSG00000068574

Gene Name

olfactory receptor family 2 subfamily R member 11

Synonyms

Olfr458, GA_x6K02T2P3E9-5100053-5100994, MOR257-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL02420

Quality Score

Status

Chromosome

Chromosomal Location

42437010-42437951 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 42437110 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 281 (V281A)

Ref Sequence

ENSEMBL: ENSMUSP00000149459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090156] [ENSMUST00000216650]

AlphaFold

Q8VF80

Predicted Effect

probably benign
Transcript: ENSMUST00000090156
AA Change: V281A

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000087617
Gene: ENSMUSG00000068574
AA Change: V281A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8.6e-52	PFAM
Pfam:7tm_1	41	310	3.7e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216650
AA Change: V281A

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsbg3	A	G	17: 57,187,494 (GRCm39)	N136S	probably damaging	Het
Adcy8	A	G	15: 64,659,303 (GRCm39)	S496P	probably damaging	Het
Agbl3	T	A	6: 34,762,242 (GRCm39)	S81T	possibly damaging	Het
Apobec1	A	T	6: 122,558,531 (GRCm39)	Y75N	probably benign	Het
Asic2	A	G	11: 80,772,479 (GRCm39)	L517P	probably benign	Het
Atp8a1	A	G	5: 67,840,126 (GRCm39)	S752P	probably damaging	Het
Blm	T	C	7: 80,145,754 (GRCm39)	Y775C	probably damaging	Het
C1qtnf5	T	C	9: 44,019,901 (GRCm39)	I175T	probably benign	Het
Ccdc81	G	A	7: 89,524,946 (GRCm39)	T545I	probably benign	Het
Ccdc88b	T	C	19: 6,834,317 (GRCm39)	E174G	probably damaging	Het
Chl1	G	A	6: 103,692,330 (GRCm39)	V1066M	probably damaging	Het
Cntn6	T	A	6: 104,823,103 (GRCm39)		probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cyren	T	C	6: 34,851,404 (GRCm39)	Y150C	probably damaging	Het
Cysrt1	T	C	2: 25,129,360 (GRCm39)	I51V	probably benign	Het
Dnah7a	T	C	1: 53,725,702 (GRCm39)	N69S	probably benign	Het
Fam83d	T	C	2: 158,627,655 (GRCm39)	L448P	probably benign	Het
Gm9631	G	A	11: 121,834,478 (GRCm39)			Het
Hmcn1	T	C	1: 150,598,175 (GRCm39)	Y1709C	probably damaging	Het
Inppl1	G	A	7: 101,481,526 (GRCm39)		probably benign	Het
Iqcc	T	C	4: 129,510,748 (GRCm39)	T256A	probably benign	Het
Itprid2	T	C	2: 79,465,986 (GRCm39)	S35P	probably damaging	Het
Lyst	G	A	13: 13,835,541 (GRCm39)	C1741Y	probably benign	Het
Lyz1	A	T	10: 117,124,535 (GRCm39)	C134S	probably damaging	Het
Mpzl3	T	C	9: 44,977,815 (GRCm39)	I141T	possibly damaging	Het
Mterf1a	T	C	5: 3,941,047 (GRCm39)	N274D	probably damaging	Het
Myo18a	T	A	11: 77,709,519 (GRCm39)	V543D	possibly damaging	Het
Myo18b	A	T	5: 112,975,852 (GRCm39)	D1332E	possibly damaging	Het
Pcdh15	A	T	10: 74,138,938 (GRCm39)	D333V	probably damaging	Het
Plekha7	A	G	7: 115,757,469 (GRCm39)	Y494H	probably damaging	Het
Plekhg1	A	G	10: 3,914,106 (GRCm39)	N1276S	probably damaging	Het
Ppig	T	C	2: 69,562,571 (GRCm39)	V5A	probably benign	Het
Prag1	A	T	8: 36,614,580 (GRCm39)		probably benign	Het
Prom1	T	C	5: 44,220,496 (GRCm39)	N84S	probably benign	Het
Ptprh	T	A	7: 4,583,929 (GRCm39)	Y221F	probably damaging	Het
Qsox2	A	G	2: 26,110,731 (GRCm39)	Y162H	probably benign	Het
Rab2a	C	T	4: 8,572,553 (GRCm39)	T49M	possibly damaging	Het
Ring1	A	G	17: 34,242,122 (GRCm39)	S96P	possibly damaging	Het
Ripk3	A	G	14: 56,022,691 (GRCm39)	F411S	probably benign	Het
Rock1	T	C	18: 10,070,619 (GRCm39)		probably null	Het
Rtn4rl1	A	G	11: 75,156,645 (GRCm39)	N359S	probably damaging	Het
Sufu	A	G	19: 46,413,481 (GRCm39)	T76A	probably damaging	Het
Sugct	C	A	13: 17,627,053 (GRCm39)	V267F	probably damaging	Het
Tcf4	A	T	18: 69,697,210 (GRCm39)	R29W	probably damaging	Het
Tnfsf18	A	T	1: 161,331,158 (GRCm39)	I103L	probably benign	Het
Vwf	A	G	6: 125,654,879 (GRCm39)	E2525G	probably benign	Het

Other mutations in Or2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00915:Or2r11	APN	6	42,437,884 (GRCm39)	missense	probably benign
IGL00983:Or2r11	APN	6	42,437,029 (GRCm39)	missense	probably benign
IGL01655:Or2r11	APN	6	42,437,474 (GRCm39)	missense	probably benign	0.41
IGL02017:Or2r11	APN	6	42,437,758 (GRCm39)	missense	probably benign	0.40
IGL03145:Or2r11	APN	6	42,437,434 (GRCm39)	missense	probably benign	0.05
IGL03171:Or2r11	APN	6	42,437,464 (GRCm39)	missense	possibly damaging	0.89
IGL03333:Or2r11	APN	6	42,437,773 (GRCm39)	missense	probably damaging	1.00
R1768:Or2r11	UTSW	6	42,437,611 (GRCm39)	missense	probably damaging	1.00
R1908:Or2r11	UTSW	6	42,437,360 (GRCm39)	missense	probably benign	0.15
R2198:Or2r11	UTSW	6	42,437,950 (GRCm39)	start codon destroyed	probably null	1.00
R2336:Or2r11	UTSW	6	42,437,663 (GRCm39)	missense	probably damaging	1.00
R2512:Or2r11	UTSW	6	42,437,207 (GRCm39)	missense	probably damaging	0.99
R3433:Or2r11	UTSW	6	42,437,888 (GRCm39)	missense	probably benign
R5338:Or2r11	UTSW	6	42,437,908 (GRCm39)	missense	probably benign	0.11
R5341:Or2r11	UTSW	6	42,437,098 (GRCm39)	missense	probably damaging	1.00
R5498:Or2r11	UTSW	6	42,437,228 (GRCm39)	missense	probably benign	0.11
R6558:Or2r11	UTSW	6	42,437,711 (GRCm39)	missense	probably benign	0.02
R6594:Or2r11	UTSW	6	42,437,309 (GRCm39)	missense	probably benign	0.01
R7107:Or2r11	UTSW	6	42,437,488 (GRCm39)	missense	possibly damaging	0.78
R7853:Or2r11	UTSW	6	42,437,573 (GRCm39)	missense	probably damaging	0.99
R8050:Or2r11	UTSW	6	42,437,764 (GRCm39)	missense	probably damaging	1.00
R8684:Or2r11	UTSW	6	42,437,827 (GRCm39)	missense	probably damaging	1.00
R9777:Or2r11	UTSW	6	42,437,029 (GRCm39)	missense	probably benign

Posted On

2015-04-16