Incidental Mutation 'IGL02423:Stk4'
ID 292761
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk4
Ensembl Gene ENSMUSG00000018209
Gene Name serine/threonine kinase 4
Synonyms sterile 20-like kinase 1, Kas-2, Ysk3, Mst1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02423
Quality Score
Status
Chromosome 2
Chromosomal Location 163916033-163997444 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 163928419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Tyrosine at position 84 (H84Y)
Ref Sequence ENSEMBL: ENSMUSP00000018353 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018353] [ENSMUST00000134078]
AlphaFold Q9JI11
Predicted Effect probably benign
Transcript: ENSMUST00000018353
AA Change: H84Y

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000018353
Gene: ENSMUSG00000018209
AA Change: H84Y

DomainStartEndE-ValueType
S_TKc 30 281 1.97e-104 SMART
low complexity region 311 326 N/A INTRINSIC
Pfam:Mst1_SARAH 433 480 2.4e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134078
AA Change: H83Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000122440
Gene: ENSMUSG00000018209
AA Change: H83Y

DomainStartEndE-ValueType
Pfam:Pkinase 29 113 7.2e-22 PFAM
Pfam:Pkinase_Tyr 29 113 1.1e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153319
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele have low numbers of na�ve T cells that are hyper-responsive to stimulation. Mice homozygous for knock-out alleles exhibit decreased peripheral T cell numbers due to impaired emigration and homing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A G 5: 99,377,236 (GRCm39) S404P probably damaging Het
A930011G23Rik G A 5: 99,377,241 (GRCm39) P402L probably damaging Het
Abca6 A G 11: 110,109,832 (GRCm39) probably benign Het
Adarb2 A T 13: 8,619,756 (GRCm39) R81W probably damaging Het
Adgrf4 T C 17: 42,983,467 (GRCm39) I72V probably benign Het
Banp A G 8: 122,733,830 (GRCm39) I360V probably benign Het
Bmp8a C A 4: 123,210,220 (GRCm39) G289C possibly damaging Het
Car3 A T 3: 14,931,911 (GRCm39) H94L probably damaging Het
Ccdc137 G A 11: 120,350,927 (GRCm39) R108H possibly damaging Het
Cdk14 T C 5: 4,938,905 (GRCm39) N411S probably benign Het
Col4a2 A G 8: 11,483,800 (GRCm39) M907V probably benign Het
Cyp4f17 T A 17: 32,725,923 (GRCm39) W19R possibly damaging Het
Dmxl2 A G 9: 54,301,032 (GRCm39) S2360P possibly damaging Het
Eif2d T G 1: 131,081,097 (GRCm39) probably benign Het
Epx A G 11: 87,762,144 (GRCm39) I369T possibly damaging Het
Fcgbp A G 7: 27,789,378 (GRCm39) E648G probably benign Het
Fer1l4 G A 2: 155,894,827 (GRCm39) P14L probably benign Het
Folr1 A G 7: 101,507,732 (GRCm39) F236S probably benign Het
Foxj2 T G 6: 122,819,732 (GRCm39) M540R possibly damaging Het
Gtf2h1 A G 7: 46,464,824 (GRCm39) T420A probably benign Het
H2-T3 T A 17: 36,498,248 (GRCm39) T222S probably damaging Het
Ice1 A T 13: 70,740,718 (GRCm39) M2163K probably damaging Het
Inppl1 A G 7: 101,481,450 (GRCm39) V244A probably benign Het
Kansl3 A T 1: 36,391,050 (GRCm39) V373D probably damaging Het
Kdm3a A G 6: 71,590,987 (GRCm39) probably benign Het
Krtap1-3 A T 11: 99,481,680 (GRCm39) C156S unknown Het
Mab21l3 T C 3: 101,726,045 (GRCm39) D317G probably damaging Het
Nherf1 A G 11: 115,054,539 (GRCm39) probably null Het
Nox3 T C 17: 3,733,191 (GRCm39) H240R probably damaging Het
Nxn A T 11: 76,164,858 (GRCm39) S218T probably benign Het
Or5h22 A T 16: 58,894,630 (GRCm39) I271K probably benign Het
Or6c35 G A 10: 129,169,397 (GRCm39) V216I probably benign Het
Pcdhb13 T C 18: 37,577,392 (GRCm39) V590A possibly damaging Het
Pim3 T C 15: 88,747,734 (GRCm39) V200A probably benign Het
Plekha3 T C 2: 76,510,524 (GRCm39) F20L probably damaging Het
Pmp22 G T 11: 63,049,118 (GRCm39) R120S possibly damaging Het
Ppp1r9a A C 6: 4,906,537 (GRCm39) D364A probably benign Het
Psd A G 19: 46,302,943 (GRCm39) F155L possibly damaging Het
Rbm22 T C 18: 60,704,891 (GRCm39) probably benign Het
Ror2 C T 13: 53,264,764 (GRCm39) S764N probably damaging Het
Ryr2 A T 13: 11,760,084 (GRCm39) F1556I probably damaging Het
Scap G A 9: 110,207,685 (GRCm39) A465T probably benign Het
Sdf2 A G 11: 78,141,844 (GRCm39) S60G probably damaging Het
Sema3a T C 5: 13,615,776 (GRCm39) I400T probably damaging Het
Ski T C 4: 155,244,191 (GRCm39) D478G probably damaging Het
Slc12a7 A T 13: 73,911,882 (GRCm39) probably benign Het
Sned1 A G 1: 93,211,322 (GRCm39) T1074A probably benign Het
Srebf2 A G 15: 82,059,298 (GRCm39) T239A probably damaging Het
Syne1 G T 10: 5,318,295 (GRCm39) Q444K probably benign Het
Tecpr1 T A 5: 144,140,305 (GRCm39) I817F possibly damaging Het
Tep1 G T 14: 51,082,077 (GRCm39) Q1159K possibly damaging Het
Tmem39b G A 4: 129,572,442 (GRCm39) H387Y probably damaging Het
Tpp1 T C 7: 105,398,907 (GRCm39) H174R probably damaging Het
Ttn C T 2: 76,535,617 (GRCm39) V35134I probably benign Het
Usp34 A G 11: 23,304,900 (GRCm39) I378V probably benign Het
Vinac1 T C 2: 128,889,968 (GRCm39) E42G probably benign Het
Vmn2r1 T A 3: 63,997,665 (GRCm39) H440Q probably benign Het
Wdr38 A T 2: 38,888,424 (GRCm39) N7I probably damaging Het
Zcchc7 T A 4: 44,931,244 (GRCm39) D144E possibly damaging Het
Zic4 C A 9: 91,266,228 (GRCm39) H284N probably damaging Het
Zkscan6 A G 11: 65,719,120 (GRCm39) H380R probably benign Het
Other mutations in Stk4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00672:Stk4 APN 2 163,959,999 (GRCm39) missense probably benign 0.05
IGL01583:Stk4 APN 2 163,916,134 (GRCm39) start codon destroyed probably null 0.21
IGL01933:Stk4 APN 2 163,940,505 (GRCm39) unclassified probably benign
IGL02084:Stk4 APN 2 163,928,527 (GRCm39) missense probably benign 0.05
IGL02601:Stk4 APN 2 163,928,462 (GRCm39) missense probably damaging 1.00
IGL02712:Stk4 APN 2 163,938,817 (GRCm39) missense probably damaging 1.00
hallon UTSW 2 163,941,747 (GRCm39) critical splice donor site probably null
iwo_jima UTSW 2 163,930,879 (GRCm39) missense possibly damaging 0.94
ribeye UTSW 2 163,921,486 (GRCm39) missense probably damaging 1.00
Sergeant UTSW 2 163,941,632 (GRCm39) missense probably benign
stryker UTSW 2 163,925,608 (GRCm39) nonsense probably null
R0377:Stk4 UTSW 2 163,938,720 (GRCm39) missense probably damaging 1.00
R0607:Stk4 UTSW 2 163,940,462 (GRCm39) missense probably damaging 1.00
R1403:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1403:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1404:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1404:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1405:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1405:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1406:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1406:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1972:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1973:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R1976:Stk4 UTSW 2 163,942,448 (GRCm39) missense probably benign 0.04
R2025:Stk4 UTSW 2 163,938,751 (GRCm39) missense probably damaging 1.00
R3155:Stk4 UTSW 2 163,993,663 (GRCm39) missense probably benign 0.01
R3732:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3732:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3733:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R3734:Stk4 UTSW 2 163,930,828 (GRCm39) missense probably benign 0.05
R4288:Stk4 UTSW 2 163,941,632 (GRCm39) missense probably benign
R4296:Stk4 UTSW 2 163,959,904 (GRCm39) missense possibly damaging 0.69
R4360:Stk4 UTSW 2 163,930,879 (GRCm39) missense possibly damaging 0.94
R4829:Stk4 UTSW 2 163,941,747 (GRCm39) critical splice donor site probably null
R4954:Stk4 UTSW 2 163,993,602 (GRCm39) missense probably damaging 1.00
R4954:Stk4 UTSW 2 163,993,601 (GRCm39) missense possibly damaging 0.75
R5088:Stk4 UTSW 2 163,925,608 (GRCm39) nonsense probably null
R5188:Stk4 UTSW 2 163,930,828 (GRCm39) missense possibly damaging 0.85
R5283:Stk4 UTSW 2 163,952,199 (GRCm39) nonsense probably null
R5554:Stk4 UTSW 2 163,941,645 (GRCm39) missense probably benign
R5605:Stk4 UTSW 2 163,921,486 (GRCm39) missense probably damaging 1.00
R5694:Stk4 UTSW 2 163,942,484 (GRCm39) missense possibly damaging 0.87
R5711:Stk4 UTSW 2 163,941,674 (GRCm39) missense probably benign 0.20
R7453:Stk4 UTSW 2 163,928,522 (GRCm39) missense probably benign 0.01
R7698:Stk4 UTSW 2 163,925,663 (GRCm39) missense probably damaging 1.00
R7726:Stk4 UTSW 2 163,952,146 (GRCm39) start codon destroyed probably null
R8177:Stk4 UTSW 2 163,930,777 (GRCm39) missense probably damaging 0.99
R9076:Stk4 UTSW 2 163,959,985 (GRCm39) missense probably benign
R9378:Stk4 UTSW 2 163,952,136 (GRCm39) intron probably benign
Posted On 2015-04-16