Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02426:Tubal3'

292898

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tubal3

Ensembl Gene

ENSMUSG00000021216

Gene Name

tubulin, alpha-like 3

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL02426

Quality Score

Status

Chromosome

Chromosomal Location

3974695-3985277 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 3982750 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 177 (S177P)

Ref Sequence

ENSEMBL: ENSMUSP00000021639 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021639]

AlphaFold

Q3UX10

Predicted Effect

probably damaging
Transcript: ENSMUST00000021639
AA Change: S177P

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000021639
Gene: ENSMUSG00000021216
AA Change: S177P

Domain	Start	End	E-Value	Type
Tubulin	56	253	9.39e-66	SMART
Tubulin_C	255	400	8.93e-49	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223035

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc5	G	A	16: 20,157,675 (GRCm39)	T1294M	probably damaging	Het
Bad	A	G	19: 6,928,785 (GRCm39)	S128G	probably damaging	Het
Casp9	T	G	4: 141,539,515 (GRCm39)		probably null	Het
Ccdc39	T	C	3: 33,879,547 (GRCm39)	K507R	possibly damaging	Het
Cep76	A	G	18: 67,767,987 (GRCm39)	S182P	probably benign	Het
Cmklr2	T	C	1: 63,222,827 (GRCm39)	Y136C	probably damaging	Het
Cmtr2	A	G	8: 110,948,322 (GRCm39)	M211V	possibly damaging	Het
Cobl	T	A	11: 12,204,351 (GRCm39)	K777*	probably null	Het
Cul9	T	G	17: 46,834,184 (GRCm39)	T1253P	possibly damaging	Het
Dmd	T	A	X: 83,892,342 (GRCm39)	L3002H	probably damaging	Het
Dnah9	C	T	11: 66,015,979 (GRCm39)	V421I	probably benign	Het
Eif4a2	A	G	16: 22,929,399 (GRCm39)	I234V	probably benign	Het
Epha4	T	C	1: 77,421,514 (GRCm39)	M323V	probably benign	Het
Fam47c	A	G	X: 77,781,943 (GRCm39)	D175G	probably benign	Het
Gm14178	T	C	11: 99,638,341 (GRCm39)			Het
Hes3	T	C	4: 152,371,397 (GRCm39)	N184S	probably benign	Het
Kdm6a	A	G	X: 18,112,549 (GRCm39)	E45G	probably damaging	Het
Kdr	T	C	5: 76,135,126 (GRCm39)	K33E	probably benign	Het
Or2a52	A	C	6: 43,144,022 (GRCm39)	D10A	probably benign	Het
Or4k37	A	T	2: 111,158,920 (GRCm39)	D52V	probably damaging	Het
Or4k45	A	T	2: 111,394,883 (GRCm39)	I302K	probably benign	Het
Or52n4b	A	G	7: 108,144,187 (GRCm39)	T150A	probably benign	Het
Or8h7	A	G	2: 86,720,964 (GRCm39)	L185S	probably damaging	Het
Pi4ka	A	T	16: 17,196,296 (GRCm39)		probably benign	Het
Pigk	T	A	3: 152,448,120 (GRCm39)		probably null	Het
Pikfyve	A	G	1: 65,290,771 (GRCm39)	T1197A	possibly damaging	Het
Plppr4	T	C	3: 117,115,944 (GRCm39)	I638V	probably benign	Het
Pramel28	T	C	4: 143,693,229 (GRCm39)	D83G	possibly damaging	Het
Rtl9	T	C	X: 141,886,098 (GRCm39)	V1170A	probably damaging	Het
Ryr3	A	G	2: 112,731,250 (GRCm39)	S687P	possibly damaging	Het
Skint5	T	C	4: 113,797,981 (GRCm39)	T201A	probably benign	Het
Socs5	G	T	17: 87,442,320 (GRCm39)	R420L	probably damaging	Het
Sos1	C	T	17: 80,742,372 (GRCm39)	S385N	possibly damaging	Het
Tomm34	A	T	2: 163,906,875 (GRCm39)	V106D	probably damaging	Het
Wbp2nl	G	A	15: 82,190,374 (GRCm39)	A101T	probably damaging	Het

Other mutations in Tubal3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00595:Tubal3	APN	13	3,983,015 (GRCm39)	missense	probably damaging	1.00
IGL02053:Tubal3	APN	13	3,983,159 (GRCm39)	missense	probably damaging	0.97
IGL02120:Tubal3	APN	13	3,980,675 (GRCm39)	missense	probably damaging	0.96
IGL02548:Tubal3	APN	13	3,980,554 (GRCm39)	missense	probably benign	0.05
IGL02981:Tubal3	APN	13	3,983,257 (GRCm39)	missense	probably benign	0.02
R0458:Tubal3	UTSW	13	3,983,137 (GRCm39)	missense	probably damaging	1.00
R1626:Tubal3	UTSW	13	3,982,841 (GRCm39)	missense	probably damaging	1.00
R1657:Tubal3	UTSW	13	3,983,011 (GRCm39)	missense	possibly damaging	0.87
R2084:Tubal3	UTSW	13	3,978,192 (GRCm39)	missense	possibly damaging	0.62
R3545:Tubal3	UTSW	13	3,983,560 (GRCm39)	makesense	probably null
R3976:Tubal3	UTSW	13	3,982,946 (GRCm39)	missense	probably benign
R4700:Tubal3	UTSW	13	3,983,514 (GRCm39)	missense	probably damaging	0.99
R4722:Tubal3	UTSW	13	3,978,185 (GRCm39)	missense	probably damaging	1.00
R5617:Tubal3	UTSW	13	3,983,432 (GRCm39)	missense	probably damaging	1.00
R6474:Tubal3	UTSW	13	3,983,107 (GRCm39)	missense	probably benign	0.10
R7049:Tubal3	UTSW	13	3,982,756 (GRCm39)	missense	probably damaging	1.00
R7082:Tubal3	UTSW	13	3,983,050 (GRCm39)	missense	possibly damaging	0.56
R7273:Tubal3	UTSW	13	3,980,675 (GRCm39)	missense	probably damaging	0.96
R7586:Tubal3	UTSW	13	3,978,198 (GRCm39)	missense	possibly damaging	0.78
R8805:Tubal3	UTSW	13	3,983,293 (GRCm39)	missense	probably damaging	1.00
R8921:Tubal3	UTSW	13	3,983,428 (GRCm39)	missense	probably damaging	1.00
R9043:Tubal3	UTSW	13	3,982,708 (GRCm39)	nonsense	probably null
R9173:Tubal3	UTSW	13	3,983,050 (GRCm39)	missense	possibly damaging	0.86
R9487:Tubal3	UTSW	13	3,980,674 (GRCm39)	missense	probably benign	0.03
Z1088:Tubal3	UTSW	13	3,983,511 (GRCm39)	missense	probably benign	0.06

Posted On

2015-04-16