Incidental Mutation 'IGL00953:Mydgf'
ID29310
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mydgf
Ensembl Gene ENSMUSG00000019579
Gene Namemyeloid derived growth factor
SynonymsD17Wsu104e
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.076) question?
Stock #IGL00953
Quality Score
Status
Chromosome17
Chromosomal Location56175744-56183920 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 56179407 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Arginine at position 75 (G75R)
Ref Sequence ENSEMBL: ENSMUSP00000019723 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019723]
Predicted Effect probably damaging
Transcript: ENSMUST00000019723
AA Change: G75R

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000019723
Gene: ENSMUSG00000019579
AA Change: G75R

DomainStartEndE-ValueType
Pfam:UPF0556 11 166 4.8e-82 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140885
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151093
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was identified in error as interleukin 25. This activity has not been reproducible, however, and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null mutation display normal cardiac and vascular development but develop larger myocardial infactions with reduced angiogenesis and increased scarring. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk T C 11: 120,011,221 E726G probably benign Het
Cdyl2 T A 8: 116,595,189 probably benign Het
Cep41 T C 6: 30,660,967 T109A probably benign Het
Clca3b C T 3: 144,847,211 W84* probably null Het
Cyp27b1 A G 10: 127,049,682 D130G probably benign Het
Cyp2f2 T C 7: 27,129,817 V249A possibly damaging Het
Cyth3 G A 5: 143,707,165 probably null Het
Dnah8 G T 17: 30,706,457 E1289* probably null Het
Fam171a1 A T 2: 3,178,290 D51V possibly damaging Het
Farp2 A G 1: 93,561,174 R107G possibly damaging Het
Gemin6 T C 17: 80,227,865 F85L possibly damaging Het
Hivep3 A C 4: 120,098,374 T1296P probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Htt T A 5: 34,818,677 S670T probably benign Het
Klhl24 A T 16: 20,122,967 N555I possibly damaging Het
Limd1 T A 9: 123,479,883 S216T probably benign Het
Lmf2 A T 15: 89,353,899 I234N probably damaging Het
Mrpl4 C A 9: 21,008,567 D271E probably benign Het
Nat1 A G 8: 67,490,978 D5G possibly damaging Het
Olfr178 A C 16: 58,889,685 H178Q probably damaging Het
Olfr190 A T 16: 59,074,689 Y130* probably null Het
Olfr325 T C 11: 58,581,810 V322A probably benign Het
Pla2g4c T A 7: 13,344,026 M363K probably benign Het
Prex1 A G 2: 166,638,409 F137S probably damaging Het
Rbm12b1 A G 4: 12,146,038 D670G probably damaging Het
Rrp12 C A 19: 41,871,792 M997I possibly damaging Het
Scn3a A G 2: 65,497,392 V918A probably benign Het
Slc35g2 A G 9: 100,552,463 V385A probably damaging Het
Slit1 A T 19: 41,602,300 I1311N probably damaging Het
Ube2j2 C T 4: 155,946,377 probably benign Het
Ucp2 A G 7: 100,498,422 T203A probably benign Het
Upk1b C T 16: 38,779,985 G211D possibly damaging Het
Vmn1r220 A T 13: 23,183,765 F254I probably benign Het
Zcchc4 T C 5: 52,808,296 F314S probably damaging Het
Other mutations in Mydgf
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1276:Mydgf UTSW 17 56179362 critical splice donor site probably null
R1616:Mydgf UTSW 17 56179415 missense possibly damaging 0.92
R4919:Mydgf UTSW 17 56176953 missense probably damaging 1.00
R5784:Mydgf UTSW 17 56178254 unclassified probably benign
R6863:Mydgf UTSW 17 56183789 missense probably damaging 0.99
R6939:Mydgf UTSW 17 56183737 critical splice donor site probably null
Posted On2013-04-17