Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02433:Muc19'

293196

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Muc19

Ensembl Gene

ENSMUSG00000044021

Gene Name

mucin 19

Synonyms

sld, apomucin

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL02433

Quality Score

Status

Chromosome

Chromosomal Location

91722531-91832440 bp(+) (GRCm39)

Type of Mutation

exon

DNA Base Change (assembly)

G to A at 91756694 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160242

SMART Domains

Protein: ENSMUSP00000125205
Gene: ENSMUSG00000044021

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
low complexity region	21	34	N/A	INTRINSIC
VWD	47	198	1.31e-13	SMART
Pfam:C8	221	293	1.1e-8	PFAM
Pfam:TIL	298	353	1.6e-11	PFAM
VWD	383	545	1.58e-25	SMART
C8	577	651	8.71e-20	SMART
Pfam:TIL	654	711	2.1e-7	PFAM
Pfam:TIL	753	813	5.2e-8	PFAM
VWD	842	1005	2.36e-47	SMART
C8	1041	1115	1.84e-27	SMART
low complexity region	1220	1254	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000178108

SMART Domains

Protein: ENSMUSP00000136475
Gene: ENSMUSG00000044021

Domain	Start	End	E-Value	Type
low complexity region	4	17	N/A	INTRINSIC
VWD	30	181	1.31e-13	SMART
Pfam:C8	200	277	2.5e-8	PFAM
Pfam:TIL	281	336	7.5e-12	PFAM
Pfam:VWD	377	477	4.1e-8	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for this spontaneous mutation show a partially arrested mucous cell differentiation of the sublingual glands. Severe inflammatory lesions resembling Sjogren's syndrome develop spontaneously in salivary and lacrimal glands of neonatally thymectomized mutants without any immunization. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bche	T	C	3: 73,609,262 (GRCm39)	T55A	probably benign	Het
Ccdc177	T	C	12: 80,804,372 (GRCm39)	D634G	unknown	Het
Cnot2	T	C	10: 116,328,241 (GRCm39)	T498A	possibly damaging	Het
Dock10	C	T	1: 80,507,905 (GRCm39)	V1669M	probably damaging	Het
Emilin2	T	C	17: 71,581,124 (GRCm39)	E534G	probably benign	Het
Flt4	G	A	11: 49,521,400 (GRCm39)	R440H	probably benign	Het
Gm10073	T	C	8: 107,299,951 (GRCm39)	Y11C	probably benign	Het
Ighv10-3	T	A	12: 114,487,514 (GRCm39)		probably benign	Het
Krt31	T	C	11: 99,939,221 (GRCm39)	Y232C	probably damaging	Het
Myof	A	G	19: 37,960,641 (GRCm39)	S467P	probably benign	Het
Nup88	C	T	11: 70,860,714 (GRCm39)	V22I	probably benign	Het
Or4f14	G	T	2: 111,742,762 (GRCm39)	P171Q	probably damaging	Het
Or6c6c	A	T	10: 129,541,445 (GRCm39)	T233S	probably benign	Het
Or8h9	A	G	2: 86,789,392 (GRCm39)	S137P	possibly damaging	Het
Prag1	C	T	8: 36,606,722 (GRCm39)	P821L	probably damaging	Het
Pramel22	C	T	4: 143,382,007 (GRCm39)	G230S	possibly damaging	Het
Tap2	G	A	17: 34,424,393 (GRCm39)		probably benign	Het
Tmem68	A	T	4: 3,569,624 (GRCm39)	I22N	possibly damaging	Het
Usp17le	A	G	7: 104,418,408 (GRCm39)	W245R	probably benign	Het
Xpo5	G	T	17: 46,550,446 (GRCm39)	C976F	probably damaging	Het
Xrcc1	T	C	7: 24,264,979 (GRCm39)	S94P	possibly damaging	Het
Zfp524	T	A	7: 5,021,091 (GRCm39)	N206K	possibly damaging	Het

Other mutations in Muc19

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00985:Muc19	APN	15	91,770,943 (GRCm39)	exon	noncoding transcript
IGL01017:Muc19	APN	15	91,764,901 (GRCm39)	exon	noncoding transcript
IGL01140:Muc19	APN	15	91,783,593 (GRCm39)	exon	noncoding transcript
IGL01292:Muc19	APN	15	91,778,470 (GRCm39)	exon	noncoding transcript
IGL01397:Muc19	APN	15	91,778,498 (GRCm39)	exon	noncoding transcript
IGL01525:Muc19	APN	15	91,770,877 (GRCm39)	exon	noncoding transcript
IGL01589:Muc19	APN	15	91,754,699 (GRCm39)	exon	noncoding transcript
IGL02023:Muc19	APN	15	91,772,453 (GRCm39)	exon	noncoding transcript
IGL02088:Muc19	APN	15	91,775,362 (GRCm39)	splice site	noncoding transcript
IGL02168:Muc19	APN	15	91,778,292 (GRCm39)	exon	noncoding transcript
IGL02343:Muc19	APN	15	91,778,428 (GRCm39)	exon	noncoding transcript
IGL02402:Muc19	APN	15	91,778,192 (GRCm39)	splice site	noncoding transcript
IGL02533:Muc19	APN	15	91,782,241 (GRCm39)	exon	noncoding transcript
IGL02558:Muc19	APN	15	91,781,816 (GRCm39)	exon	noncoding transcript
IGL02652:Muc19	APN	15	91,762,009 (GRCm39)	critical splice donor site	noncoding transcript
IGL03032:Muc19	APN	15	91,808,424 (GRCm39)	unclassified	noncoding transcript
IGL02837:Muc19	UTSW	15	91,766,850 (GRCm39)	exon	noncoding transcript
R0098:Muc19	UTSW	15	91,777,101 (GRCm39)	exon	noncoding transcript
R0098:Muc19	UTSW	15	91,777,101 (GRCm39)	exon	noncoding transcript
R0208:Muc19	UTSW	15	91,777,218 (GRCm39)	splice site	noncoding transcript
R0597:Muc19	UTSW	15	91,784,696 (GRCm39)	splice site	noncoding transcript
R1185:Muc19	UTSW	15	91,762,743 (GRCm39)	exon	noncoding transcript
R1185:Muc19	UTSW	15	91,762,743 (GRCm39)	exon	noncoding transcript
R1469:Muc19	UTSW	15	91,758,498 (GRCm39)	unclassified	noncoding transcript
R1942:Muc19	UTSW	15	91,776,666 (GRCm39)	exon	noncoding transcript
R2035:Muc19	UTSW	15	91,776,599 (GRCm39)	splice site	noncoding transcript
R2208:Muc19	UTSW	15	91,755,747 (GRCm39)	exon	noncoding transcript
R2877:Muc19	UTSW	15	91,777,200 (GRCm39)	exon	noncoding transcript
R2897:Muc19	UTSW	15	91,822,550 (GRCm39)	critical splice donor site	noncoding transcript
R4110:Muc19	UTSW	15	91,781,816 (GRCm39)	exon	noncoding transcript
R4403:Muc19	UTSW	15	91,755,768 (GRCm39)	exon	noncoding transcript
R4606:Muc19	UTSW	15	91,832,268 (GRCm39)	exon	noncoding transcript
R4677:Muc19	UTSW	15	91,772,411 (GRCm39)	exon	noncoding transcript
R4753:Muc19	UTSW	15	91,761,955 (GRCm39)	unclassified	noncoding transcript
R4781:Muc19	UTSW	15	91,787,360 (GRCm39)	critical splice donor site	noncoding transcript
R4869:Muc19	UTSW	15	91,781,910 (GRCm39)	exon	noncoding transcript
R5000:Muc19	UTSW	15	91,757,429 (GRCm39)	unclassified	noncoding transcript
R5044:Muc19	UTSW	15	91,772,332 (GRCm39)	exon	noncoding transcript
R5156:Muc19	UTSW	15	91,784,614 (GRCm39)	exon	noncoding transcript
R5176:Muc19	UTSW	15	91,776,374 (GRCm39)	exon	noncoding transcript
R5224:Muc19	UTSW	15	91,825,910 (GRCm39)	exon	noncoding transcript
R5524:Muc19	UTSW	15	91,778,587 (GRCm39)	exon	noncoding transcript
R5568:Muc19	UTSW	15	91,768,468 (GRCm39)	splice site	noncoding transcript
R5592:Muc19	UTSW	15	91,828,199 (GRCm39)	exon	noncoding transcript

Posted On

2015-04-16