Incidental Mutation 'IGL02439:Timd2'
ID 293403
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Timd2
Ensembl Gene ENSMUSG00000040413
Gene Name T cell immunoglobulin and mucin domain containing 2
Synonyms TIM-2, Tim2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # IGL02439
Quality Score
Status
Chromosome 11
Chromosomal Location 46559787-46597888 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 46569063 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000131540 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055102] [ENSMUST00000109225] [ENSMUST00000169584]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000055102
SMART Domains Protein: ENSMUSP00000060891
Gene: ENSMUSG00000040413

DomainStartEndE-ValueType
IG 22 127 7.08e-4 SMART
low complexity region 131 146 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
transmembrane domain 231 253 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109225
SMART Domains Protein: ENSMUSP00000104848
Gene: ENSMUSG00000040413

DomainStartEndE-ValueType
IG 22 127 7.08e-4 SMART
low complexity region 131 146 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
transmembrane domain 231 253 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000169584
SMART Domains Protein: ENSMUSP00000131540
Gene: ENSMUSG00000040413

DomainStartEndE-ValueType
IG 22 127 7.08e-4 SMART
low complexity region 131 146 N/A INTRINSIC
low complexity region 148 167 N/A INTRINSIC
transmembrane domain 231 253 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit an exacerbated inflammatory response. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610042L04Rik A T 14: 4,348,890 (GRCm38) Y17F probably benign Het
Ablim2 A C 5: 36,015,206 (GRCm39) T507P possibly damaging Het
Arhgef28 T C 13: 98,067,647 (GRCm39) Y1426C possibly damaging Het
Cftr T A 6: 18,258,237 (GRCm39) Y592* probably null Het
Eogt C T 6: 97,120,934 (GRCm39) G93D possibly damaging Het
Exosc9 A G 3: 36,607,180 (GRCm39) probably benign Het
Frem1 T C 4: 82,874,582 (GRCm39) I1329V probably benign Het
Gal3st1 T C 11: 3,948,110 (GRCm39) F106L possibly damaging Het
Gulp1 A T 1: 44,820,164 (GRCm39) I216F probably damaging Het
Ints13 A T 6: 146,455,721 (GRCm39) probably benign Het
Kars1 G A 8: 112,724,268 (GRCm39) T453I probably benign Het
Kif14 A G 1: 136,417,999 (GRCm39) D844G probably damaging Het
Lgals3bp A T 11: 118,289,046 (GRCm39) C93S probably damaging Het
Lst1 T C 17: 35,405,958 (GRCm39) I32V probably benign Het
Malsu1 T A 6: 49,052,121 (GRCm39) Y114N probably damaging Het
Ndufa5 A T 6: 24,519,201 (GRCm39) V41E probably damaging Het
Nme6 C A 9: 109,670,999 (GRCm39) P80T probably damaging Het
Odad2 T A 18: 7,268,444 (GRCm39) R358S probably benign Het
Or5ac20 A G 16: 59,104,818 (GRCm39) L14P probably damaging Het
Padi4 T C 4: 140,473,532 (GRCm39) D635G probably damaging Het
Pcf11 C T 7: 92,311,049 (GRCm39) S313N possibly damaging Het
Pdik1l T C 4: 134,006,015 (GRCm39) H309R probably benign Het
Pdk2 A T 11: 94,930,323 (GRCm39) probably benign Het
Pprc1 A G 19: 46,060,758 (GRCm39) S1606G possibly damaging Het
Ptch1 A G 13: 63,692,910 (GRCm39) I230T probably damaging Het
Scn10a C T 9: 119,447,914 (GRCm39) R1381Q probably benign Het
Sestd1 T C 2: 77,027,174 (GRCm39) K479E possibly damaging Het
Sez6l2 C T 7: 126,567,361 (GRCm39) S892L probably damaging Het
Slc39a9 G T 12: 80,713,350 (GRCm39) A83S probably benign Het
Slc6a6 A G 6: 91,726,808 (GRCm39) Y483C probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Tas2r131 A G 6: 132,934,732 (GRCm39) S26P probably damaging Het
Tmem126a T C 7: 90,104,641 (GRCm39) E27G probably damaging Het
Tns2 G A 15: 102,022,978 (GRCm39) G1256E probably damaging Het
Trpv6 T A 6: 41,602,421 (GRCm39) I322F probably damaging Het
Tshr G A 12: 91,504,321 (GRCm39) V420M probably damaging Het
Ttn C A 2: 76,596,431 (GRCm39) A20161S probably damaging Het
Vmn2r66 A T 7: 84,654,455 (GRCm39) probably benign Het
Zfp438 T A 18: 5,213,216 (GRCm39) S581C probably damaging Het
Other mutations in Timd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Timd2 APN 11 46,567,170 (GRCm39) missense probably benign 0.15
IGL01289:Timd2 APN 11 46,570,499 (GRCm39) missense probably benign 0.00
IGL02066:Timd2 APN 11 46,569,050 (GRCm39) missense probably damaging 0.98
R2217:Timd2 UTSW 11 46,577,844 (GRCm39) missense probably damaging 1.00
R2218:Timd2 UTSW 11 46,577,844 (GRCm39) missense probably damaging 1.00
R2240:Timd2 UTSW 11 46,569,043 (GRCm39) missense probably benign 0.01
R3621:Timd2 UTSW 11 46,569,040 (GRCm39) missense probably benign 0.00
R3876:Timd2 UTSW 11 46,561,847 (GRCm39) critical splice acceptor site probably null
R4173:Timd2 UTSW 11 46,561,787 (GRCm39) missense probably benign 0.00
R4793:Timd2 UTSW 11 46,578,008 (GRCm39) missense probably damaging 1.00
R4799:Timd2 UTSW 11 46,568,094 (GRCm39) nonsense probably null
R4963:Timd2 UTSW 11 46,573,617 (GRCm39) missense possibly damaging 0.66
R5314:Timd2 UTSW 11 46,568,087 (GRCm39) missense probably benign 0.09
R5798:Timd2 UTSW 11 46,568,064 (GRCm39) missense probably benign 0.06
R6074:Timd2 UTSW 11 46,577,999 (GRCm39) missense possibly damaging 0.88
R6090:Timd2 UTSW 11 46,578,063 (GRCm39) missense probably benign 0.11
R6694:Timd2 UTSW 11 46,561,779 (GRCm39) nonsense probably null
R7817:Timd2 UTSW 11 46,561,781 (GRCm39) missense probably benign 0.00
R8379:Timd2 UTSW 11 46,568,027 (GRCm39) splice site probably null
R9321:Timd2 UTSW 11 46,577,916 (GRCm39) missense probably benign 0.00
R9483:Timd2 UTSW 11 46,577,889 (GRCm39) missense probably damaging 1.00
R9763:Timd2 UTSW 11 46,573,540 (GRCm39) missense probably benign 0.01
Z1177:Timd2 UTSW 11 46,570,506 (GRCm39) missense probably benign 0.26
Posted On 2015-04-16