Incidental Mutation 'IGL02444:Lpar3'
ID 293503
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lpar3
Ensembl Gene ENSMUSG00000036832
Gene Name lysophosphatidic acid receptor 3
Synonyms Edg7, LPA3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02444
Quality Score
Status
Chromosome 3
Chromosomal Location 145926718-145991941 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145946949 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 209 (I209T)
Ref Sequence ENSEMBL: ENSMUSP00000037712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039164]
AlphaFold Q9EQ31
Predicted Effect probably damaging
Transcript: ENSMUST00000039164
AA Change: I209T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037712
Gene: ENSMUSG00000036832
AA Change: I209T

DomainStartEndE-ValueType
Pfam:7tm_1 47 293 2.4e-37 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A G 8: 44,022,710 (GRCm39) I260T possibly damaging Het
Arhgap9 T A 10: 127,163,816 (GRCm39) V484D probably damaging Het
Asph A G 4: 9,542,319 (GRCm39) probably benign Het
Bbs9 T C 9: 22,555,083 (GRCm39) S457P probably damaging Het
Bckdk A G 7: 127,506,618 (GRCm39) T38A probably damaging Het
Cast G A 13: 74,887,972 (GRCm39) T240I probably damaging Het
Cdc27 T C 11: 104,413,542 (GRCm39) probably benign Het
Cdon T C 9: 35,384,744 (GRCm39) S677P probably benign Het
Cfap161 T C 7: 83,425,353 (GRCm39) E246G probably damaging Het
Dnah11 G A 12: 117,939,608 (GRCm39) probably benign Het
Dnm3 C T 1: 161,838,444 (GRCm39) V835I possibly damaging Het
Eif3a T C 19: 60,762,045 (GRCm39) H510R possibly damaging Het
Fbxw2 G T 2: 34,695,793 (GRCm39) T367K probably benign Het
Ghsr T C 3: 27,426,189 (GRCm39) S82P probably benign Het
Gm4353 C T 7: 115,682,679 (GRCm39) V301I probably benign Het
Golgb1 T C 16: 36,728,178 (GRCm39) probably benign Het
Gria2 T A 3: 80,609,860 (GRCm39) M650L possibly damaging Het
Herc4 T C 10: 63,142,212 (GRCm39) V671A probably benign Het
Iqcb1 T A 16: 36,652,273 (GRCm39) Y61* probably null Het
Irs2 C T 8: 11,056,306 (GRCm39) G709S probably benign Het
Itpripl1 T G 2: 126,983,621 (GRCm39) H167P possibly damaging Het
Kcnn3 T C 3: 89,559,359 (GRCm39) V543A possibly damaging Het
Klf10 T A 15: 38,298,068 (GRCm39) K43M probably damaging Het
Lcor C T 19: 41,547,450 (GRCm39) R345C probably damaging Het
Lmntd2 A G 7: 140,791,832 (GRCm39) S304P probably damaging Het
Map3k13 T A 16: 21,732,982 (GRCm39) M528K probably benign Het
Me1 A T 9: 86,464,967 (GRCm39) probably benign Het
Nedd4l T G 18: 65,337,028 (GRCm39) probably benign Het
Oas1d T A 5: 121,058,071 (GRCm39) F338L probably benign Het
Or1b1 G T 2: 36,994,786 (GRCm39) P292Q probably damaging Het
Or2c1 T C 16: 3,657,551 (GRCm39) F238S probably damaging Het
Pcdhb5 T C 18: 37,454,103 (GRCm39) V161A probably benign Het
Prdx3 A T 19: 60,859,899 (GRCm39) F91L possibly damaging Het
Rab25 T C 3: 88,450,020 (GRCm39) T114A probably benign Het
Rasal2 T C 1: 157,126,765 (GRCm39) E73G probably benign Het
Slco4c1 A G 1: 96,772,234 (GRCm39) S252P probably damaging Het
Srgap2 A C 1: 131,252,891 (GRCm39) probably null Het
Synpo A G 18: 60,735,502 (GRCm39) S576P probably damaging Het
Tktl2 G T 8: 66,966,013 (GRCm39) A524S possibly damaging Het
Tln2 A T 9: 67,165,874 (GRCm39) probably benign Het
Tmem52 G A 4: 155,554,850 (GRCm39) D158N probably damaging Het
Tyw3 T A 3: 154,302,626 (GRCm39) Q36L probably damaging Het
Usp10 A T 8: 120,675,432 (GRCm39) I483F possibly damaging Het
Usp31 A G 7: 121,278,718 (GRCm39) Y216H probably damaging Het
Vmn1r181 T C 7: 23,683,948 (GRCm39) S138P probably damaging Het
Vmn2r42 G T 7: 8,187,312 (GRCm39) A770E probably damaging Het
Zfp292 A C 4: 34,808,810 (GRCm39) S1411R possibly damaging Het
Other mutations in Lpar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0656:Lpar3 UTSW 3 145,946,426 (GRCm39) missense possibly damaging 0.54
R0893:Lpar3 UTSW 3 145,946,348 (GRCm39) missense possibly damaging 0.82
R1809:Lpar3 UTSW 3 145,946,303 (GRCm39) splice site probably benign
R4937:Lpar3 UTSW 3 145,990,506 (GRCm39) missense probably damaging 0.98
R6116:Lpar3 UTSW 3 145,946,352 (GRCm39) missense possibly damaging 0.70
R6587:Lpar3 UTSW 3 145,946,918 (GRCm39) missense probably damaging 1.00
R7232:Lpar3 UTSW 3 145,947,061 (GRCm39) critical splice donor site probably null
R8029:Lpar3 UTSW 3 145,946,718 (GRCm39) missense probably benign 0.01
R8266:Lpar3 UTSW 3 145,946,385 (GRCm39) missense probably benign 0.02
R9676:Lpar3 UTSW 3 145,990,434 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16