Incidental Mutation 'IGL02444:Cdon'
ID 293515
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdon
Ensembl Gene ENSMUSG00000038119
Gene Name cell adhesion molecule-related/down-regulated by oncogenes
Synonyms CAM-related/down-regulated by oncogenes, CDO
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.351) question?
Stock # IGL02444
Quality Score
Status
Chromosome 9
Chromosomal Location 35332836-35418948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 35384744 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 677 (S677P)
Ref Sequence ENSEMBL: ENSMUSP00000113977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129] [ENSMUST00000154652]
AlphaFold Q32MD9
Predicted Effect probably benign
Transcript: ENSMUST00000042842
AA Change: S677P

PolyPhen 2 Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: S677P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000084000
Predicted Effect probably benign
Transcript: ENSMUST00000119129
AA Change: S677P

PolyPhen 2 Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: S677P

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127264
SMART Domains Protein: ENSMUSP00000115216
Gene: ENSMUSG00000038119

DomainStartEndE-ValueType
IGc2 1 51 6.26e-5 SMART
IG_like 18 62 1.06e2 SMART
IGc2 81 134 6.45e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154652
SMART Domains Protein: ENSMUSP00000117499
Gene: ENSMUSG00000038119

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam26a A G 8: 44,022,710 (GRCm39) I260T possibly damaging Het
Arhgap9 T A 10: 127,163,816 (GRCm39) V484D probably damaging Het
Asph A G 4: 9,542,319 (GRCm39) probably benign Het
Bbs9 T C 9: 22,555,083 (GRCm39) S457P probably damaging Het
Bckdk A G 7: 127,506,618 (GRCm39) T38A probably damaging Het
Cast G A 13: 74,887,972 (GRCm39) T240I probably damaging Het
Cdc27 T C 11: 104,413,542 (GRCm39) probably benign Het
Cfap161 T C 7: 83,425,353 (GRCm39) E246G probably damaging Het
Dnah11 G A 12: 117,939,608 (GRCm39) probably benign Het
Dnm3 C T 1: 161,838,444 (GRCm39) V835I possibly damaging Het
Eif3a T C 19: 60,762,045 (GRCm39) H510R possibly damaging Het
Fbxw2 G T 2: 34,695,793 (GRCm39) T367K probably benign Het
Ghsr T C 3: 27,426,189 (GRCm39) S82P probably benign Het
Gm4353 C T 7: 115,682,679 (GRCm39) V301I probably benign Het
Golgb1 T C 16: 36,728,178 (GRCm39) probably benign Het
Gria2 T A 3: 80,609,860 (GRCm39) M650L possibly damaging Het
Herc4 T C 10: 63,142,212 (GRCm39) V671A probably benign Het
Iqcb1 T A 16: 36,652,273 (GRCm39) Y61* probably null Het
Irs2 C T 8: 11,056,306 (GRCm39) G709S probably benign Het
Itpripl1 T G 2: 126,983,621 (GRCm39) H167P possibly damaging Het
Kcnn3 T C 3: 89,559,359 (GRCm39) V543A possibly damaging Het
Klf10 T A 15: 38,298,068 (GRCm39) K43M probably damaging Het
Lcor C T 19: 41,547,450 (GRCm39) R345C probably damaging Het
Lmntd2 A G 7: 140,791,832 (GRCm39) S304P probably damaging Het
Lpar3 T C 3: 145,946,949 (GRCm39) I209T probably damaging Het
Map3k13 T A 16: 21,732,982 (GRCm39) M528K probably benign Het
Me1 A T 9: 86,464,967 (GRCm39) probably benign Het
Nedd4l T G 18: 65,337,028 (GRCm39) probably benign Het
Oas1d T A 5: 121,058,071 (GRCm39) F338L probably benign Het
Or1b1 G T 2: 36,994,786 (GRCm39) P292Q probably damaging Het
Or2c1 T C 16: 3,657,551 (GRCm39) F238S probably damaging Het
Pcdhb5 T C 18: 37,454,103 (GRCm39) V161A probably benign Het
Prdx3 A T 19: 60,859,899 (GRCm39) F91L possibly damaging Het
Rab25 T C 3: 88,450,020 (GRCm39) T114A probably benign Het
Rasal2 T C 1: 157,126,765 (GRCm39) E73G probably benign Het
Slco4c1 A G 1: 96,772,234 (GRCm39) S252P probably damaging Het
Srgap2 A C 1: 131,252,891 (GRCm39) probably null Het
Synpo A G 18: 60,735,502 (GRCm39) S576P probably damaging Het
Tktl2 G T 8: 66,966,013 (GRCm39) A524S possibly damaging Het
Tln2 A T 9: 67,165,874 (GRCm39) probably benign Het
Tmem52 G A 4: 155,554,850 (GRCm39) D158N probably damaging Het
Tyw3 T A 3: 154,302,626 (GRCm39) Q36L probably damaging Het
Usp10 A T 8: 120,675,432 (GRCm39) I483F possibly damaging Het
Usp31 A G 7: 121,278,718 (GRCm39) Y216H probably damaging Het
Vmn1r181 T C 7: 23,683,948 (GRCm39) S138P probably damaging Het
Vmn2r42 G T 7: 8,187,312 (GRCm39) A770E probably damaging Het
Zfp292 A C 4: 34,808,810 (GRCm39) S1411R possibly damaging Het
Other mutations in Cdon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Cdon APN 9 35,389,412 (GRCm39) missense probably damaging 1.00
IGL01307:Cdon APN 9 35,368,860 (GRCm39) missense probably benign 0.01
IGL01528:Cdon APN 9 35,381,403 (GRCm39) missense possibly damaging 0.95
IGL01663:Cdon APN 9 35,394,510 (GRCm39) missense possibly damaging 0.57
IGL01723:Cdon APN 9 35,414,634 (GRCm39) missense probably benign 0.05
IGL02200:Cdon APN 9 35,394,405 (GRCm39) missense probably benign 0.28
IGL02547:Cdon APN 9 35,389,950 (GRCm39) missense probably damaging 1.00
IGL02620:Cdon APN 9 35,364,095 (GRCm39) missense probably benign 0.00
IGL02861:Cdon APN 9 35,398,253 (GRCm39) missense probably damaging 0.96
IGL02894:Cdon APN 9 35,366,722 (GRCm39) missense probably benign 0.01
IGL03153:Cdon APN 9 35,389,255 (GRCm39) missense probably damaging 1.00
IGL03206:Cdon APN 9 35,414,602 (GRCm39) missense probably benign
IGL03374:Cdon APN 9 35,389,299 (GRCm39) missense possibly damaging 0.46
corleone UTSW 9 35,398,252 (GRCm39) nonsense probably null
indentured UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
Molar UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
Servitude UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
PIT4280001:Cdon UTSW 9 35,398,231 (GRCm39) missense probably damaging 1.00
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0064:Cdon UTSW 9 35,400,523 (GRCm39) missense probably benign 0.03
R0396:Cdon UTSW 9 35,381,426 (GRCm39) missense probably damaging 1.00
R0403:Cdon UTSW 9 35,384,796 (GRCm39) missense probably benign 0.00
R0490:Cdon UTSW 9 35,363,978 (GRCm39) missense probably damaging 1.00
R0547:Cdon UTSW 9 35,368,794 (GRCm39) missense possibly damaging 0.88
R0609:Cdon UTSW 9 35,389,907 (GRCm39) missense probably damaging 1.00
R0645:Cdon UTSW 9 35,388,379 (GRCm39) splice site probably null
R0781:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1110:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1391:Cdon UTSW 9 35,415,485 (GRCm39) missense possibly damaging 0.51
R1574:Cdon UTSW 9 35,364,233 (GRCm39) splice site probably benign
R1851:Cdon UTSW 9 35,394,454 (GRCm39) missense probably damaging 1.00
R2031:Cdon UTSW 9 35,415,370 (GRCm39) missense probably damaging 0.96
R2230:Cdon UTSW 9 35,403,222 (GRCm39) critical splice donor site probably null
R3683:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3684:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3685:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3941:Cdon UTSW 9 35,375,467 (GRCm39) missense probably benign 0.09
R4030:Cdon UTSW 9 35,403,202 (GRCm39) missense probably damaging 1.00
R4084:Cdon UTSW 9 35,389,427 (GRCm39) missense probably damaging 0.98
R4462:Cdon UTSW 9 35,368,876 (GRCm39) missense probably damaging 0.97
R4569:Cdon UTSW 9 35,388,265 (GRCm39) missense probably damaging 1.00
R4677:Cdon UTSW 9 35,389,901 (GRCm39) missense probably damaging 1.00
R4869:Cdon UTSW 9 35,364,200 (GRCm39) missense possibly damaging 0.71
R5032:Cdon UTSW 9 35,400,330 (GRCm39) missense probably damaging 1.00
R5047:Cdon UTSW 9 35,389,935 (GRCm39) missense probably damaging 1.00
R5214:Cdon UTSW 9 35,394,504 (GRCm39) missense probably damaging 1.00
R5341:Cdon UTSW 9 35,381,431 (GRCm39) missense probably damaging 1.00
R5410:Cdon UTSW 9 35,381,331 (GRCm39) missense probably damaging 0.99
R5581:Cdon UTSW 9 35,415,377 (GRCm39) missense probably benign 0.01
R5696:Cdon UTSW 9 35,403,162 (GRCm39) missense possibly damaging 0.69
R5757:Cdon UTSW 9 35,364,068 (GRCm39) missense probably damaging 0.98
R5802:Cdon UTSW 9 35,365,716 (GRCm39) missense probably damaging 0.99
R5845:Cdon UTSW 9 35,368,762 (GRCm39) missense probably damaging 1.00
R5949:Cdon UTSW 9 35,398,247 (GRCm39) missense probably benign 0.32
R6106:Cdon UTSW 9 35,366,704 (GRCm39) nonsense probably null
R6245:Cdon UTSW 9 35,388,235 (GRCm39) missense probably damaging 1.00
R6845:Cdon UTSW 9 35,398,252 (GRCm39) nonsense probably null
R6896:Cdon UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
R7060:Cdon UTSW 9 35,398,205 (GRCm39) missense probably damaging 1.00
R7076:Cdon UTSW 9 35,415,446 (GRCm39) missense probably benign 0.00
R7184:Cdon UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
R7382:Cdon UTSW 9 35,389,944 (GRCm39) missense probably damaging 1.00
R7763:Cdon UTSW 9 35,365,711 (GRCm39) nonsense probably null
R7857:Cdon UTSW 9 35,367,908 (GRCm39) missense possibly damaging 0.79
R7885:Cdon UTSW 9 35,367,818 (GRCm39) missense probably benign 0.01
R7894:Cdon UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
R7984:Cdon UTSW 9 35,414,598 (GRCm39) missense probably benign 0.00
R8287:Cdon UTSW 9 35,375,225 (GRCm39) missense probably benign
R8428:Cdon UTSW 9 35,403,163 (GRCm39) missense probably benign 0.21
R8519:Cdon UTSW 9 35,389,950 (GRCm39) missense probably damaging 1.00
R8698:Cdon UTSW 9 35,398,269 (GRCm39) critical splice donor site probably null
R8797:Cdon UTSW 9 35,389,931 (GRCm39) missense probably damaging 1.00
R8995:Cdon UTSW 9 35,398,093 (GRCm39) missense probably damaging 1.00
R9090:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9177:Cdon UTSW 9 35,381,230 (GRCm39) missense probably benign 0.00
R9200:Cdon UTSW 9 35,414,617 (GRCm39) missense probably benign 0.00
R9271:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9330:Cdon UTSW 9 35,400,275 (GRCm39) nonsense probably null
R9477:Cdon UTSW 9 35,403,201 (GRCm39) missense probably damaging 1.00
R9612:Cdon UTSW 9 35,398,201 (GRCm39) missense probably damaging 1.00
R9730:Cdon UTSW 9 35,398,263 (GRCm39) missense probably benign 0.00
Z1177:Cdon UTSW 9 35,403,196 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16