Incidental Mutation 'IGL02445:Coprs'
ID 293542
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Coprs
Ensembl Gene ENSMUSG00000031458
Gene Name coordinator of PRMT5, differentiation stimulator
Synonyms 2410022L05Rik, MGC11316, 1700029I03Rik, COPR5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.110) question?
Stock # IGL02445
Quality Score
Status
Chromosome 8
Chromosomal Location 13934794-13940281 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13935797 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 74 (K74R)
Ref Sequence ENSEMBL: ENSMUSP00000033839 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033839] [ENSMUST00000051870] [ENSMUST00000128557] [ENSMUST00000209371]
AlphaFold Q9CQ13
Predicted Effect possibly damaging
Transcript: ENSMUST00000033839
AA Change: K74R

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000033839
Gene: ENSMUSG00000031458
AA Change: K74R

DomainStartEndE-ValueType
Pfam:COPR5 24 173 1.3e-87 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000051870
SMART Domains Protein: ENSMUSP00000057270
Gene: ENSMUSG00000047710

DomainStartEndE-ValueType
ZnF_C2H2 14 37 1.62e0 SMART
ZnF_C2H2 62 85 2.29e1 SMART
internal_repeat_1 109 278 1.19e-9 PROSPERO
low complexity region 298 318 N/A INTRINSIC
low complexity region 354 368 N/A INTRINSIC
internal_repeat_1 373 534 1.19e-9 PROSPERO
low complexity region 602 613 N/A INTRINSIC
low complexity region 677 690 N/A INTRINSIC
ZnF_C2H2 699 722 2.68e1 SMART
ZnF_C2H2 728 750 1.79e-2 SMART
ZnF_C2H2 755 776 2.23e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000128557
SMART Domains Protein: ENSMUSP00000120117
Gene: ENSMUSG00000047710

DomainStartEndE-ValueType
ZnF_C2H2 14 37 1.62e0 SMART
ZnF_C2H2 62 85 2.29e1 SMART
internal_repeat_1 109 278 5.23e-7 PROSPERO
low complexity region 298 318 N/A INTRINSIC
low complexity region 354 368 N/A INTRINSIC
internal_repeat_1 373 534 5.23e-7 PROSPERO
low complexity region 602 613 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000209371
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210188
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210249
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210749
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced retroperitoneal white adipose tissue with fewer and larger adipocytes. In vitro adipogenic conversion of embryoid bodies and primary embryonic fibroblasts is markedly delayed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb C T 5: 114,383,198 (GRCm39) T2127M probably damaging Het
Acp2 A G 2: 91,036,606 (GRCm39) D175G possibly damaging Het
Adamts12 T C 15: 11,286,798 (GRCm39) L801P probably damaging Het
Adcy10 T G 1: 165,398,313 (GRCm39) V1470G possibly damaging Het
Ankar T G 1: 72,705,524 (GRCm39) K829Q probably benign Het
Arhgef10l T C 4: 140,274,318 (GRCm39) Y531C probably benign Het
Atm T C 9: 53,365,630 (GRCm39) I2590V probably benign Het
Brme1 T A 8: 84,886,137 (GRCm39) M31K probably benign Het
Cblb T C 16: 51,986,668 (GRCm39) L485P probably damaging Het
Col4a1 T C 8: 11,283,911 (GRCm39) probably benign Het
Cul3 A T 1: 80,281,886 (GRCm39) L31M possibly damaging Het
Cyp3a59 C A 5: 146,033,463 (GRCm39) Q200K probably benign Het
Ddx19b C A 8: 111,735,456 (GRCm39) V402L probably damaging Het
Disc1 T A 8: 125,875,142 (GRCm39) probably benign Het
Dsg4 C T 18: 20,579,307 (GRCm39) probably benign Het
Dspp A C 5: 104,324,963 (GRCm39) Y442S probably damaging Het
Dtl C T 1: 191,290,172 (GRCm39) probably null Het
Ezh1 A C 11: 101,101,513 (GRCm39) V175G possibly damaging Het
Hepacam2 C T 6: 3,483,481 (GRCm39) G100D probably damaging Het
Herc1 T A 9: 66,340,764 (GRCm39) H1704Q possibly damaging Het
Itprid2 G A 2: 79,487,842 (GRCm39) E642K probably damaging Het
Kif26a T C 12: 112,140,177 (GRCm39) S469P probably damaging Het
Lefty1 T C 1: 180,765,242 (GRCm39) M270T probably benign Het
Nap1l3 A T X: 121,305,752 (GRCm39) V322D probably damaging Het
Ndufv2 A G 17: 66,387,889 (GRCm39) probably benign Het
Or14j5 A T 17: 38,162,008 (GRCm39) H175L probably damaging Het
Or4p18 G A 2: 88,232,456 (GRCm39) T274I possibly damaging Het
Or8b55 T C 9: 38,726,901 (GRCm39) I34T possibly damaging Het
Otol1 A T 3: 69,935,367 (GRCm39) D453V probably damaging Het
Papolb G A 5: 142,514,480 (GRCm39) H388Y probably benign Het
Ppp1r10 A G 17: 36,237,094 (GRCm39) E128G probably damaging Het
Prss12 T A 3: 123,280,669 (GRCm39) D451E probably damaging Het
Psmc1 T C 12: 100,081,087 (GRCm39) probably benign Het
Pygo1 T A 9: 72,833,222 (GRCm39) I10N probably benign Het
Rab31 C T 17: 66,028,998 (GRCm39) probably null Het
Ret G A 6: 118,158,860 (GRCm39) T184I probably damaging Het
Rhd A T 4: 134,611,481 (GRCm39) M214L possibly damaging Het
Ripor3 C A 2: 167,834,682 (GRCm39) probably benign Het
Sec16a A G 2: 26,312,052 (GRCm39) L2036P probably benign Het
Slc26a3 C A 12: 31,507,051 (GRCm39) D335E possibly damaging Het
Taf6 A G 5: 138,182,756 (GRCm39) probably benign Het
Tnk2 T C 16: 32,494,408 (GRCm39) V442A probably benign Het
Virma A G 4: 11,527,029 (GRCm39) M1143V probably damaging Het
Vmn2r77 A T 7: 86,452,848 (GRCm39) R522* probably null Het
Vmn2r-ps129 A G 17: 23,227,393 (GRCm39) noncoding transcript Het
Zfp473 A G 7: 44,383,107 (GRCm39) C408R probably damaging Het
Other mutations in Coprs
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02947:Coprs APN 8 13,935,782 (GRCm39) missense probably damaging 0.98
R1669:Coprs UTSW 8 13,935,704 (GRCm39) nonsense probably null
R1874:Coprs UTSW 8 13,935,112 (GRCm39) missense probably damaging 1.00
R6974:Coprs UTSW 8 13,935,750 (GRCm39) missense probably benign 0.04
R8516:Coprs UTSW 8 13,935,065 (GRCm39) missense probably damaging 1.00
R9514:Coprs UTSW 8 13,935,081 (GRCm39) missense probably damaging 1.00
R9515:Coprs UTSW 8 13,935,081 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16