Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00979:Vmn2r106'

29356

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

IGL00979

Quality Score

Status

Chromosome

Chromosomal Location

20487809-20505692 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 20497837 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 467 (D467E)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167464
AA Change: D467E

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: D467E

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427I04Rik	A	T	4: 123,754,338 (GRCm39)	K84M	probably damaging	Het
A4gnt	T	A	9: 99,502,489 (GRCm39)	Y216*	probably null	Het
Abcb1b	A	G	5: 8,875,293 (GRCm39)		probably benign	Het
Ankrd50	G	A	3: 38,506,563 (GRCm39)		probably benign	Het
Catsperb	A	G	12: 101,381,584 (GRCm39)	T89A	probably benign	Het
Ccdc15	C	T	9: 37,227,786 (GRCm39)	S236N	probably benign	Het
Cd34	A	C	1: 194,631,816 (GRCm39)	T151P	possibly damaging	Het
Col28a1	A	T	6: 8,014,810 (GRCm39)	V865E	probably damaging	Het
Csf2rb	T	A	15: 78,232,304 (GRCm39)	V537E	probably damaging	Het
Cux2	A	G	5: 122,011,777 (GRCm39)	F553L	probably damaging	Het
Dolk	A	T	2: 30,174,743 (GRCm39)	L434Q	probably damaging	Het
Dsg2	C	A	18: 20,715,824 (GRCm39)	D255E	probably damaging	Het
Endov	T	C	11: 119,391,444 (GRCm39)	V144A	probably damaging	Het
Grik2	T	C	10: 49,232,034 (GRCm39)	N499D	probably damaging	Het
Hephl1	G	T	9: 14,978,341 (GRCm39)	T855K	probably benign	Het
Hif1a	A	G	12: 73,988,784 (GRCm39)	D557G	probably damaging	Het
Idh1	G	A	1: 65,210,308 (GRCm39)	T75I	probably damaging	Het
Ighv1-37	A	G	12: 114,860,070 (GRCm39)	S47P	probably benign	Het
Irx4	A	G	13: 73,416,341 (GRCm39)		probably benign	Het
Itpr1	C	T	6: 108,448,081 (GRCm39)	A1871V	probably damaging	Het
Klkb1	A	G	8: 45,747,105 (GRCm39)		probably benign	Het
Lrrc8e	T	C	8: 4,285,080 (GRCm39)	L435P	probably damaging	Het
Megf11	T	A	9: 64,416,009 (GRCm39)	Y73N	probably damaging	Het
Nfe2	T	C	15: 103,157,607 (GRCm39)	D128G	probably damaging	Het
Or13a22	A	G	7: 140,072,614 (GRCm39)	E21G	probably benign	Het
Or4k51	T	A	2: 111,584,771 (GRCm39)	M59K	probably damaging	Het
Pak6	C	A	2: 118,526,963 (GRCm39)	L653I	probably damaging	Het
Pde4dip	T	A	3: 97,655,074 (GRCm39)		probably benign	Het
Pds5a	A	G	5: 65,789,066 (GRCm39)	V831A	probably benign	Het
Prc1	G	T	7: 79,957,444 (GRCm39)		probably null	Het
Ptprs	C	T	17: 56,765,243 (GRCm39)	G14S	probably damaging	Het
Pygb	A	G	2: 150,661,833 (GRCm39)	K520E	probably benign	Het
Rimbp2	A	G	5: 128,883,505 (GRCm39)	S92P	probably benign	Het
Samd4b	A	T	7: 28,113,638 (GRCm39)	L109Q	probably damaging	Het
Saxo4	T	C	19: 10,451,863 (GRCm39)	*428W	probably null	Het
Scn8a	A	T	15: 100,853,287 (GRCm39)		probably benign	Het
Sdc3	A	G	4: 130,545,991 (GRCm39)	I23V	unknown	Het
Sec61a2	A	G	2: 5,876,831 (GRCm39)	Y350H	possibly damaging	Het
Slc4a3	A	T	1: 75,530,891 (GRCm39)	Q759L	probably damaging	Het
Speg	C	T	1: 75,387,378 (GRCm39)	P1378L	probably damaging	Het
Spta1	T	G	1: 174,035,956 (GRCm39)	Y1087*	probably null	Het
Tenm4	A	G	7: 96,378,598 (GRCm39)	E401G	probably damaging	Het
Tom1	C	A	8: 75,781,331 (GRCm39)		probably benign	Het
Ttc3	T	A	16: 94,257,577 (GRCm39)	V1273D	probably damaging	Het
Washc4	A	T	10: 83,386,747 (GRCm39)	T124S	probably benign	Het
Zfp790	A	G	7: 29,529,034 (GRCm39)	E573G	probably benign	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01313:Vmn2r106	APN	17	20,498,651 (GRCm39)	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20,499,807 (GRCm39)	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20,488,572 (GRCm39)	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20,488,314 (GRCm39)	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20,497,730 (GRCm39)	missense	probably benign	0.06
IGL01895:Vmn2r106	APN	17	20,499,227 (GRCm39)	missense	probably benign	0.02
IGL02378:Vmn2r106	APN	17	20,497,791 (GRCm39)	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20,499,158 (GRCm39)	missense	probably benign	0.38
IGL02664:Vmn2r106	APN	17	20,488,344 (GRCm39)	missense	possibly damaging	0.88
IGL03308:Vmn2r106	APN	17	20,498,785 (GRCm39)	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20,488,405 (GRCm39)	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20,499,281 (GRCm39)	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20,488,465 (GRCm39)	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20,487,859 (GRCm39)	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20,499,741 (GRCm39)	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20,499,373 (GRCm39)	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20,498,997 (GRCm39)	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20,488,560 (GRCm39)	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20,488,566 (GRCm39)	missense	possibly damaging	0.90
R2245:Vmn2r106	UTSW	17	20,488,423 (GRCm39)	missense	probably benign	0.13
R2336:Vmn2r106	UTSW	17	20,488,470 (GRCm39)	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20,498,946 (GRCm39)	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20,499,147 (GRCm39)	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20,487,913 (GRCm39)	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20,487,818 (GRCm39)	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20,488,080 (GRCm39)	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20,499,910 (GRCm39)	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20,497,728 (GRCm39)	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20,487,885 (GRCm39)	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20,499,395 (GRCm39)	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20,497,788 (GRCm39)	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20,498,684 (GRCm39)	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20,499,133 (GRCm39)	missense	probably benign
R5859:Vmn2r106	UTSW	17	20,505,583 (GRCm39)	missense	possibly damaging	0.72
R5937:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	nonsense	probably null
R5972:Vmn2r106	UTSW	17	20,498,738 (GRCm39)	missense	probably benign
R6056:Vmn2r106	UTSW	17	20,487,806 (GRCm39)	splice site	probably null
R6108:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20,488,666 (GRCm39)	missense	probably benign
R6208:Vmn2r106	UTSW	17	20,488,591 (GRCm39)	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20,488,501 (GRCm39)	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20,498,667 (GRCm39)	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6405:Vmn2r106	UTSW	17	20,499,361 (GRCm39)	missense	probably benign	0.22
R6427:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6730:Vmn2r106	UTSW	17	20,499,096 (GRCm39)	missense	possibly damaging	0.64
R6961:Vmn2r106	UTSW	17	20,488,646 (GRCm39)	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20,499,182 (GRCm39)	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20,488,037 (GRCm39)	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20,487,883 (GRCm39)	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20,488,201 (GRCm39)	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20,505,490 (GRCm39)	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20,499,271 (GRCm39)	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20,487,868 (GRCm39)	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20,488,401 (GRCm39)	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.17

Posted On

2013-04-17