Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02451:Or10ag59'

293635

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10ag59

Ensembl Gene

ENSMUSG00000062272

Gene Name

olfactory receptor family 10 subfamily AG member 59

Synonyms

GA_x6K02T2Q125-49078087-49079031, MOR264-23, MOR264-9P, Olfr1129

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL02451

Quality Score

Status

Chromosome

Chromosomal Location

87405430-87406374 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 87405576 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Arginine at position 49 (S49R)

Ref Sequence

ENSEMBL: ENSMUSP00000150986 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081034] [ENSMUST00000213315] [ENSMUST00000214773]

AlphaFold

A2AV41

Predicted Effect

probably benign
Transcript: ENSMUST00000081034
AA Change: S49R

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000079823
Gene: ENSMUSG00000062272
AA Change: S49R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	6e-53	PFAM
Pfam:7tm_1	47	296	2.1e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213315
AA Change: S49R

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

Predicted Effect

probably benign
Transcript: ENSMUST00000214773
AA Change: S49R

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700123K08Rik	T	G	5: 138,561,809 (GRCm39)	T126P	probably damaging	Het
Asic2	T	C	11: 80,782,563 (GRCm39)		probably benign	Het
B430305J03Rik	A	G	3: 61,271,562 (GRCm39)		probably benign	Het
Bbs7	A	G	3: 36,664,741 (GRCm39)	F47L	possibly damaging	Het
Bcl2l14	G	T	6: 134,400,804 (GRCm39)	G75V	probably benign	Het
Btnl4	T	C	17: 34,694,901 (GRCm39)	H4R	probably benign	Het
Champ1	C	A	8: 13,928,739 (GRCm39)	P299Q	probably damaging	Het
Cimap3	T	A	3: 105,921,820 (GRCm39)	E34D	probably benign	Het
Cldnd2	A	G	7: 43,091,082 (GRCm39)	K5E	probably benign	Het
Ctr9	T	A	7: 110,642,631 (GRCm39)	L401*	probably null	Het
Cyp2c29	G	A	19: 39,279,291 (GRCm39)	G96D	possibly damaging	Het
Enpp4	A	T	17: 44,412,315 (GRCm39)	L298H	probably damaging	Het
Git1	T	C	11: 77,391,513 (GRCm39)	C222R	possibly damaging	Het
Gpam	T	C	19: 55,076,635 (GRCm39)	T189A	probably damaging	Het
Hgfac	T	G	5: 35,201,158 (GRCm39)		probably null	Het
Hivep3	T	A	4: 119,991,162 (GRCm39)	S2221T	probably damaging	Het
Ifi47	T	C	11: 48,986,604 (GRCm39)	Y124H	probably damaging	Het
Il1a	T	C	2: 129,148,575 (GRCm39)	E45G	probably damaging	Het
Itga11	T	A	9: 62,642,635 (GRCm39)	I186N	probably damaging	Het
Krt16	A	T	11: 100,137,162 (GRCm39)		probably benign	Het
Mapk13	A	G	17: 28,995,387 (GRCm39)	T203A	probably damaging	Het
Mrpl37	T	A	4: 106,923,839 (GRCm39)	I52F	probably damaging	Het
Mtrex	C	T	13: 113,027,881 (GRCm39)	V660M	probably damaging	Het
Nr1i2	A	G	16: 38,069,654 (GRCm39)	F417L	probably benign	Het
Or6c215	G	A	10: 129,637,702 (GRCm39)	Q231*	probably null	Het
Osbpl1a	T	C	18: 13,047,550 (GRCm39)		probably benign	Het
Parg	C	T	14: 31,964,186 (GRCm39)	T112M	probably damaging	Het
Pou6f1	T	C	15: 100,477,821 (GRCm39)	T166A	possibly damaging	Het
Prtg	A	G	9: 72,764,281 (GRCm39)	I585V	possibly damaging	Het
Ptpru	T	G	4: 131,504,086 (GRCm39)		probably benign	Het
Rab6a	T	C	7: 100,285,970 (GRCm39)		probably null	Het
Rnf207	C	T	4: 152,396,869 (GRCm39)	R425H	probably benign	Het
Rusf1	A	G	7: 127,875,582 (GRCm39)	L257P	probably damaging	Het
Slc27a2	A	G	2: 126,420,912 (GRCm39)	M468V	probably benign	Het
Slc30a1	A	G	1: 191,639,441 (GRCm39)	H108R	possibly damaging	Het
Sned1	A	G	1: 93,163,930 (GRCm39)		probably benign	Het
Sptbn4	A	T	7: 27,065,014 (GRCm39)	F2095Y	probably null	Het
Sspo	A	T	6: 48,437,237 (GRCm39)		probably benign	Het
Tbx19	A	G	1: 164,967,740 (GRCm39)	S336P	probably benign	Het
Tmem101	T	A	11: 102,044,119 (GRCm39)	D256V	probably damaging	Het
Trbv20	T	G	6: 41,165,210 (GRCm39)	L2V	unknown	Het
Trpc7	A	G	13: 56,970,274 (GRCm39)	S382P	probably damaging	Het
Tut4	C	A	4: 108,386,473 (GRCm39)	Y1114*	probably null	Het
Uhmk1	T	C	1: 170,040,095 (GRCm39)	T91A	possibly damaging	Het
Vmn2r10	T	A	5: 109,143,788 (GRCm39)	R721*	probably null	Het
Vmn2r94	T	A	17: 18,478,453 (GRCm39)	Y98F	possibly damaging	Het
Zfp532	A	G	18: 65,756,672 (GRCm39)	R202G	probably damaging	Het
Zfp827	T	C	8: 79,787,601 (GRCm39)	S256P	probably damaging	Het
Zzef1	T	C	11: 72,792,214 (GRCm39)	I2266T	probably damaging	Het

Other mutations in Or10ag59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01312:Or10ag59	APN	2	87,405,518 (GRCm39)	missense	probably damaging	1.00
IGL01731:Or10ag59	APN	2	87,406,282 (GRCm39)	missense	probably benign	0.26
IGL01819:Or10ag59	APN	2	87,405,823 (GRCm39)	missense	probably damaging	1.00
IGL01995:Or10ag59	APN	2	87,405,806 (GRCm39)	missense	probably damaging	1.00
IGL02280:Or10ag59	APN	2	87,405,689 (GRCm39)	missense	probably damaging	0.98
IGL02514:Or10ag59	APN	2	87,405,537 (GRCm39)	missense	probably benign
IGL03039:Or10ag59	APN	2	87,405,536 (GRCm39)	missense	probably benign	0.01
IGL03074:Or10ag59	APN	2	87,405,680 (GRCm39)	missense	possibly damaging	0.66
R0396:Or10ag59	UTSW	2	87,405,911 (GRCm39)	missense	possibly damaging	0.95
R0960:Or10ag59	UTSW	2	87,406,279 (GRCm39)	missense	probably benign	0.44
R1955:Or10ag59	UTSW	2	87,406,349 (GRCm39)	missense	probably damaging	1.00
R2006:Or10ag59	UTSW	2	87,405,536 (GRCm39)	missense	probably benign	0.01
R3752:Or10ag59	UTSW	2	87,406,057 (GRCm39)	missense	probably benign
R4546:Or10ag59	UTSW	2	87,405,530 (GRCm39)	missense	probably benign	0.03
R4812:Or10ag59	UTSW	2	87,406,087 (GRCm39)	missense	probably benign	0.11
R5327:Or10ag59	UTSW	2	87,406,043 (GRCm39)	missense	probably damaging	1.00
R5845:Or10ag59	UTSW	2	87,406,367 (GRCm39)	missense	probably benign	0.06
R6057:Or10ag59	UTSW	2	87,406,363 (GRCm39)	missense	probably benign
R6087:Or10ag59	UTSW	2	87,406,259 (GRCm39)	missense	probably benign	0.43
R6125:Or10ag59	UTSW	2	87,405,590 (GRCm39)	missense	probably benign	0.01
R6496:Or10ag59	UTSW	2	87,405,460 (GRCm39)	missense	probably damaging	1.00
R6805:Or10ag59	UTSW	2	87,405,262 (GRCm39)	splice site	probably null
R6967:Or10ag59	UTSW	2	87,405,857 (GRCm39)	missense	possibly damaging	0.50
R7286:Or10ag59	UTSW	2	87,405,863 (GRCm39)	missense	probably benign	0.00
R7296:Or10ag59	UTSW	2	87,406,052 (GRCm39)	missense	probably damaging	1.00
R7496:Or10ag59	UTSW	2	87,405,715 (GRCm39)	missense	probably damaging	1.00
R7753:Or10ag59	UTSW	2	87,406,141 (GRCm39)	missense	probably benign	0.16
R8444:Or10ag59	UTSW	2	87,406,083 (GRCm39)	missense	probably benign
Z1088:Or10ag59	UTSW	2	87,406,024 (GRCm39)	missense	possibly damaging	0.88

Posted On

2015-04-16