Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02454:Tnks'

293779

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tnks

Ensembl Gene

ENSMUSG00000031529

Gene Name

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Synonyms

mTNKS1, TANK1, tankyrase 1, 4930554K12Rik, D130072O21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02454

Quality Score

Status

Chromosome

Chromosomal Location

35296333-35432844 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

C to T at 35298882 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033929]

AlphaFold

Q6PFX9

Predicted Effect

probably benign
Transcript: ENSMUST00000033929

SMART Domains

Protein: ENSMUSP00000033929
Gene: ENSMUSG00000031529

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
low complexity region	20	55	N/A	INTRINSIC
low complexity region	68	86	N/A	INTRINSIC
low complexity region	91	175	N/A	INTRINSIC
ANK	208	237	4.26e-4	SMART
ANK	241	270	3.23e-4	SMART
ANK	274	303	3.28e-5	SMART
ANK	327	355	2.66e3	SMART
ANK	361	390	7.64e-6	SMART
ANK	394	423	2.62e-4	SMART
ANK	427	456	1.99e-4	SMART
ANK	514	546	3.18e-3	SMART
ANK	550	579	1.51e-4	SMART
ANK	583	612	4.26e-4	SMART
ANK	642	670	2.21e3	SMART
ANK	676	705	4.03e-5	SMART
ANK	709	738	2.48e-5	SMART
ANK	742	771	1.64e-5	SMART
low complexity region	792	810	N/A	INTRINSIC
ANK	829	858	1.47e-7	SMART
ANK	862	891	2.21e-2	SMART
ANK	895	924	3.13e-2	SMART
low complexity region	996	1010	N/A	INTRINSIC
SAM	1017	1082	1.14e-12	SMART
Pfam:PARP	1098	1303	1.5e-28	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000209632

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000209904

Predicted Effect

probably benign
Transcript: ENSMUST00000210014

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele fail to exhibit any abonormalities. Male mice homozygous for a gene trapped allele exhibit decreased fat pad weight, increased metabolism, hyperinsulinemia, and hypoglycemia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Amz2	T	G	11: 109,324,887 (GRCm39)		probably benign	Het
Atp13a5	A	G	16: 29,051,560 (GRCm39)	F1104S	probably benign	Het
Cacna1c	T	C	6: 118,579,141 (GRCm39)	N1610S	probably damaging	Het
Ccnl1	A	T	3: 65,864,318 (GRCm39)	D122E	probably damaging	Het
Crtc2	G	A	3: 90,166,474 (GRCm39)	G65S	probably benign	Het
Dnah17	T	C	11: 117,971,593 (GRCm39)	T2160A	probably damaging	Het
Fads3	T	G	19: 10,032,483 (GRCm39)	L278R	probably damaging	Het
Foxp4	A	T	17: 48,186,507 (GRCm39)	L424*	probably null	Het
Gm10392	A	T	11: 77,409,216 (GRCm39)	E310V	probably damaging	Het
Gm11554	T	A	11: 99,694,815 (GRCm39)	S133C	unknown	Het
Hacd2	T	A	16: 34,926,761 (GRCm39)	F253L	probably benign	Het
Il3ra	T	C	14: 14,351,113 (GRCm38)	S212P	probably benign	Het
Mdn1	T	C	4: 32,694,674 (GRCm39)		probably null	Het
Mtfr1l	A	T	4: 134,257,696 (GRCm39)	L111H	probably damaging	Het
Mysm1	A	G	4: 94,858,741 (GRCm39)		probably benign	Het
Or10j2	C	A	1: 173,098,507 (GRCm39)	S255Y	probably damaging	Het
Or52d1	T	C	7: 103,755,819 (GRCm39)	V111A	probably damaging	Het
Plec	A	T	15: 76,075,231 (GRCm39)	F357I	probably damaging	Het
Polr3a	C	A	14: 24,525,891 (GRCm39)	V450L	possibly damaging	Het
Prkd1	T	C	12: 50,411,456 (GRCm39)	K764R	probably benign	Het
Pxn	C	T	5: 115,690,325 (GRCm39)	P256S	probably damaging	Het
Rbm25	T	A	12: 83,707,096 (GRCm39)	F247L	probably benign	Het
Rfx4	C	T	10: 84,675,970 (GRCm39)	T62M	possibly damaging	Het
Rps4l-ps	T	C	7: 114,526,499 (GRCm39)		noncoding transcript	Het
Scn11a	A	G	9: 119,587,610 (GRCm39)	I1378T	probably benign	Het
Siglecg	T	C	7: 43,058,319 (GRCm39)	S69P	probably benign	Het
Stox1	T	C	10: 62,503,605 (GRCm39)	Y61C	probably damaging	Het
Tex55	T	A	16: 38,648,309 (GRCm39)	T267S	probably benign	Het
Tpr	A	G	1: 150,306,943 (GRCm39)	S1587G	probably benign	Het
Trappc6b	A	G	12: 59,090,433 (GRCm39)	*97Q	probably null	Het
Usf3	T	C	16: 44,037,545 (GRCm39)	V675A	probably damaging	Het
Wdr7	C	T	18: 63,929,299 (GRCm39)	T1045M	probably benign	Het
Zc3h11a	A	T	1: 133,552,254 (GRCm39)	C618S	probably benign	Het
Zfp398	T	C	6: 47,817,301 (GRCm39)	V47A	possibly damaging	Het
Zzz3	A	G	3: 152,134,211 (GRCm39)	N423S	probably benign	Het

Other mutations in Tnks

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Tnks	APN	8	35,328,843 (GRCm39)	splice site	probably benign
IGL00901:Tnks	APN	8	35,305,549 (GRCm39)	nonsense	probably null
IGL01448:Tnks	APN	8	35,307,136 (GRCm39)	missense	probably damaging	1.00
IGL01455:Tnks	APN	8	35,408,054 (GRCm39)	missense	probably damaging	0.99
IGL01962:Tnks	APN	8	35,336,678 (GRCm39)	missense	probably damaging	1.00
IGL02088:Tnks	APN	8	35,307,148 (GRCm39)	missense	possibly damaging	0.50
IGL02260:Tnks	APN	8	35,310,137 (GRCm39)	missense	probably damaging	0.99
IGL02486:Tnks	APN	8	35,318,352 (GRCm39)	missense	probably damaging	1.00
IGL02612:Tnks	APN	8	35,316,453 (GRCm39)	missense	possibly damaging	0.48
IGL03179:Tnks	APN	8	35,315,824 (GRCm39)	missense	probably benign	0.38
IGL03404:Tnks	APN	8	35,407,858 (GRCm39)	missense	probably damaging	1.00
R0256:Tnks	UTSW	8	35,328,701 (GRCm39)	missense	probably benign	0.07
R0265:Tnks	UTSW	8	35,307,124 (GRCm39)	nonsense	probably null
R0334:Tnks	UTSW	8	35,320,413 (GRCm39)	nonsense	probably null
R0414:Tnks	UTSW	8	35,320,463 (GRCm39)	missense	probably damaging	1.00
R0526:Tnks	UTSW	8	35,320,457 (GRCm39)	missense	probably benign	0.23
R0622:Tnks	UTSW	8	35,407,976 (GRCm39)	missense	probably damaging	1.00
R1445:Tnks	UTSW	8	35,301,757 (GRCm39)	splice site	probably benign
R1618:Tnks	UTSW	8	35,342,430 (GRCm39)	missense	probably damaging	1.00
R1779:Tnks	UTSW	8	35,324,672 (GRCm39)	missense	probably benign	0.18
R1919:Tnks	UTSW	8	35,342,386 (GRCm39)	missense	probably damaging	1.00
R1938:Tnks	UTSW	8	35,305,684 (GRCm39)	missense	probably damaging	1.00
R2018:Tnks	UTSW	8	35,318,260 (GRCm39)	missense	probably damaging	1.00
R2198:Tnks	UTSW	8	35,340,221 (GRCm39)	missense	probably benign	0.29
R2198:Tnks	UTSW	8	35,315,803 (GRCm39)	missense	probably benign
R2925:Tnks	UTSW	8	35,432,815 (GRCm39)	missense	unknown
R3828:Tnks	UTSW	8	35,340,332 (GRCm39)	missense	probably damaging	1.00
R3913:Tnks	UTSW	8	35,340,228 (GRCm39)	missense	probably damaging	0.99
R3916:Tnks	UTSW	8	35,320,515 (GRCm39)	missense	probably damaging	1.00
R3917:Tnks	UTSW	8	35,320,515 (GRCm39)	missense	probably damaging	1.00
R3930:Tnks	UTSW	8	35,407,966 (GRCm39)	missense	probably damaging	1.00
R4659:Tnks	UTSW	8	35,316,465 (GRCm39)	missense	possibly damaging	0.53
R4760:Tnks	UTSW	8	35,318,937 (GRCm39)	missense	probably benign	0.38
R5091:Tnks	UTSW	8	35,308,963 (GRCm39)	missense	probably benign	0.40
R5419:Tnks	UTSW	8	35,432,720 (GRCm39)	missense	unknown
R5558:Tnks	UTSW	8	35,432,819 (GRCm39)	start codon destroyed	probably null
R5582:Tnks	UTSW	8	35,408,015 (GRCm39)	missense	probably benign	0.14
R6035:Tnks	UTSW	8	35,385,615 (GRCm39)	missense	possibly damaging	0.93
R6035:Tnks	UTSW	8	35,385,615 (GRCm39)	missense	possibly damaging	0.93
R6495:Tnks	UTSW	8	35,307,120 (GRCm39)	critical splice donor site	probably null
R6527:Tnks	UTSW	8	35,340,247 (GRCm39)	missense	probably benign	0.36
R6991:Tnks	UTSW	8	35,301,647 (GRCm39)	missense	probably damaging	1.00
R7015:Tnks	UTSW	8	35,305,701 (GRCm39)	missense	probably benign	0.04
R7038:Tnks	UTSW	8	35,318,790 (GRCm39)	missense	probably damaging	0.99
R7057:Tnks	UTSW	8	35,307,168 (GRCm39)	missense	probably damaging	1.00
R7167:Tnks	UTSW	8	35,316,458 (GRCm39)	missense	probably damaging	0.98
R7250:Tnks	UTSW	8	35,318,912 (GRCm39)	missense	probably damaging	0.98
R7475:Tnks	UTSW	8	35,298,866 (GRCm39)	missense	probably damaging	1.00
R7790:Tnks	UTSW	8	35,328,694 (GRCm39)	missense	probably benign	0.01
R7818:Tnks	UTSW	8	35,340,182 (GRCm39)	missense	probably benign	0.03
R7909:Tnks	UTSW	8	35,407,858 (GRCm39)	missense	probably damaging	1.00
R7970:Tnks	UTSW	8	35,323,080 (GRCm39)	critical splice donor site	probably null
R8341:Tnks	UTSW	8	35,340,199 (GRCm39)	missense	probably damaging	1.00
R8343:Tnks	UTSW	8	35,301,738 (GRCm39)	missense	probably benign	0.03
R8870:Tnks	UTSW	8	35,314,433 (GRCm39)	critical splice donor site	probably null
R8936:Tnks	UTSW	8	35,320,501 (GRCm39)	nonsense	probably null
R9049:Tnks	UTSW	8	35,308,932 (GRCm39)	missense	probably damaging	0.96
R9080:Tnks	UTSW	8	35,432,466 (GRCm39)	small deletion	probably benign
R9182:Tnks	UTSW	8	35,308,905 (GRCm39)	critical splice donor site	probably null
R9211:Tnks	UTSW	8	35,316,489 (GRCm39)	missense	probably damaging	1.00
R9425:Tnks	UTSW	8	35,340,819 (GRCm39)	missense	probably damaging	1.00
R9649:Tnks	UTSW	8	35,306,089 (GRCm39)	missense	probably damaging	0.96
Z1177:Tnks	UTSW	8	35,432,299 (GRCm39)	missense	probably benign	0.04

Posted On

2015-04-16