Incidental Mutation 'IGL02391:Amn1'
| ID |
293873 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Amn1
|
| Ensembl Gene |
ENSMUSG00000068250 |
| Gene Name |
antagonist of mitotic exit network 1 |
| Synonyms |
C730024G19Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
IGL02391
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
149059075-149090210 bp(-) (GRCm39) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
A to G
at 149070944 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107160
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095319]
[ENSMUST00000111535]
[ENSMUST00000141346]
|
| AlphaFold |
B8JKV0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000095319
|
| SMART Domains |
Protein: ENSMUSP00000092957
Gene: ENSMUSG00000068250
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
17 |
41 |
2.82e0 |
SMART |
|
LRR
|
42 |
70 |
1.52e2 |
SMART |
|
LRR
|
71 |
96 |
1.25e-1 |
SMART |
|
LRR
|
97 |
122 |
3.89e-3 |
SMART |
|
LRR
|
123 |
147 |
1.44e1 |
SMART |
|
LRR
|
150 |
175 |
1.28e1 |
SMART |
|
Blast:LRR
|
176 |
204 |
3e-10 |
BLAST |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000111535
|
| SMART Domains |
Protein: ENSMUSP00000107160
Gene: ENSMUSG00000068250
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
60 |
84 |
2.82e0 |
SMART |
|
LRR
|
85 |
113 |
1.52e2 |
SMART |
|
LRR
|
114 |
139 |
1.25e-1 |
SMART |
|
LRR
|
140 |
165 |
3.89e-3 |
SMART |
|
LRR
|
166 |
190 |
1.44e1 |
SMART |
|
LRR
|
193 |
218 |
1.28e1 |
SMART |
|
Blast:LRR
|
219 |
247 |
4e-10 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127743
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134181
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141346
|
| SMART Domains |
Protein: ENSMUSP00000116060
Gene: ENSMUSG00000068250
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
17 |
41 |
2.82e0 |
SMART |
|
LRR
|
42 |
70 |
1.52e2 |
SMART |
|
LRR
|
71 |
96 |
1.25e-1 |
SMART |
|
LRR
|
97 |
121 |
1.44e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149149
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150610
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000204681
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156864
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000203043
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152062
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 44 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc4 |
T |
A |
14: 118,790,764 (GRCm39) |
N748Y |
probably damaging |
Het |
| Actbl2 |
A |
G |
13: 111,391,701 (GRCm39) |
D12G |
possibly damaging |
Het |
| Adamts10 |
T |
C |
17: 33,747,785 (GRCm39) |
S74P |
probably benign |
Het |
| Adprs |
C |
T |
4: 126,211,701 (GRCm39) |
|
probably benign |
Het |
| Antxr1 |
A |
T |
6: 87,264,038 (GRCm39) |
I144N |
probably damaging |
Het |
| Atp2a3 |
C |
A |
11: 72,866,165 (GRCm39) |
H262N |
probably benign |
Het |
| Cabp5 |
A |
T |
7: 13,132,269 (GRCm39) |
R13* |
probably null |
Het |
| Cacna1e |
A |
G |
1: 154,296,859 (GRCm39) |
Y1669H |
probably damaging |
Het |
| Ccdc174 |
A |
G |
6: 91,875,263 (GRCm39) |
E364G |
possibly damaging |
Het |
| Ccdc18 |
C |
T |
5: 108,283,918 (GRCm39) |
P74S |
probably damaging |
Het |
| Clec3a |
C |
T |
8: 115,152,240 (GRCm39) |
S82L |
probably benign |
Het |
| Cnih3 |
A |
G |
1: 181,234,078 (GRCm39) |
D43G |
probably damaging |
Het |
| Dpp10 |
G |
A |
1: 123,578,087 (GRCm39) |
T128M |
probably damaging |
Het |
| Edar |
A |
T |
10: 58,464,403 (GRCm39) |
F79I |
probably damaging |
Het |
| Eif2ak4 |
T |
A |
2: 118,251,272 (GRCm39) |
H199Q |
probably benign |
Het |
| Fermt1 |
A |
G |
2: 132,783,871 (GRCm39) |
L46P |
probably damaging |
Het |
| Glipr1 |
A |
G |
10: 111,824,799 (GRCm39) |
|
probably benign |
Het |
| Gsdmc |
T |
C |
15: 63,675,428 (GRCm39) |
N129S |
probably damaging |
Het |
| Ift88 |
T |
C |
14: 57,718,871 (GRCm39) |
S619P |
possibly damaging |
Het |
| Itga9 |
T |
A |
9: 118,679,873 (GRCm39) |
V262E |
probably benign |
Het |
| Med17 |
G |
A |
9: 15,188,963 (GRCm39) |
R101* |
probably null |
Het |
| Mta1 |
T |
A |
12: 113,100,203 (GRCm39) |
I688N |
possibly damaging |
Het |
| Muc4 |
A |
T |
16: 32,570,894 (GRCm39) |
R651S |
probably benign |
Het |
| Opcml |
A |
G |
9: 28,586,560 (GRCm39) |
I93V |
probably damaging |
Het |
| Or12d17 |
C |
T |
17: 37,777,477 (GRCm39) |
P127S |
probably damaging |
Het |
| Or13p4 |
A |
G |
4: 118,547,538 (GRCm39) |
L37P |
probably damaging |
Het |
| Or9r7 |
A |
G |
10: 129,962,773 (GRCm39) |
V51A |
possibly damaging |
Het |
| Parg |
T |
G |
14: 31,984,638 (GRCm39) |
|
probably null |
Het |
| Rps3a3 |
A |
G |
13: 108,807,417 (GRCm39) |
|
probably benign |
Het |
| Safb |
T |
A |
17: 56,907,813 (GRCm39) |
|
probably benign |
Het |
| Sat2 |
G |
T |
11: 69,513,575 (GRCm39) |
C54F |
probably damaging |
Het |
| Scin |
T |
A |
12: 40,127,530 (GRCm39) |
Y420F |
probably benign |
Het |
| Slc22a29 |
A |
T |
19: 8,146,717 (GRCm39) |
S362T |
probably benign |
Het |
| Smchd1 |
T |
C |
17: 71,738,254 (GRCm39) |
D537G |
probably null |
Het |
| Spred3 |
A |
G |
7: 28,865,830 (GRCm39) |
S126P |
probably benign |
Het |
| Ssh1 |
C |
T |
5: 114,080,578 (GRCm39) |
E951K |
probably damaging |
Het |
| Ssmem1 |
A |
G |
6: 30,512,441 (GRCm39) |
E28G |
possibly damaging |
Het |
| Stox1 |
A |
T |
10: 62,495,455 (GRCm39) |
|
probably benign |
Het |
| Syn3 |
T |
C |
10: 85,900,770 (GRCm39) |
I373V |
probably benign |
Het |
| Tecrl |
A |
T |
5: 83,502,674 (GRCm39) |
F58L |
probably benign |
Het |
| Trp53bp1 |
T |
C |
2: 121,033,191 (GRCm39) |
N1655S |
possibly damaging |
Het |
| Usp2 |
G |
T |
9: 44,002,524 (GRCm39) |
Q147H |
probably damaging |
Het |
| Usp24 |
T |
A |
4: 106,264,326 (GRCm39) |
N1751K |
possibly damaging |
Het |
| Wipf1 |
T |
A |
2: 73,264,487 (GRCm39) |
D438V |
probably damaging |
Het |
|
| Other mutations in Amn1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
PIT4453001:Amn1
|
UTSW |
6 |
149,072,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0153:Amn1
|
UTSW |
6 |
149,090,091 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R0494:Amn1
|
UTSW |
6 |
149,086,634 (GRCm39) |
unclassified |
probably benign |
|
|
R0557:Amn1
|
UTSW |
6 |
149,072,503 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R0717:Amn1
|
UTSW |
6 |
149,084,970 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0736:Amn1
|
UTSW |
6 |
149,084,970 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3420:Amn1
|
UTSW |
6 |
149,070,950 (GRCm39) |
nonsense |
probably null |
|
|
R3421:Amn1
|
UTSW |
6 |
149,070,950 (GRCm39) |
nonsense |
probably null |
|
|
R4466:Amn1
|
UTSW |
6 |
149,068,343 (GRCm39) |
splice site |
probably null |
|
|
R4760:Amn1
|
UTSW |
6 |
149,086,611 (GRCm39) |
missense |
probably benign |
|
|
R5294:Amn1
|
UTSW |
6 |
149,086,622 (GRCm39) |
unclassified |
probably benign |
|
|
R5356:Amn1
|
UTSW |
6 |
149,068,392 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5561:Amn1
|
UTSW |
6 |
149,086,522 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7501:Amn1
|
UTSW |
6 |
149,086,529 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7564:Amn1
|
UTSW |
6 |
149,086,529 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7643:Amn1
|
UTSW |
6 |
149,086,529 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7645:Amn1
|
UTSW |
6 |
149,086,529 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8097:Amn1
|
UTSW |
6 |
149,070,853 (GRCm39) |
unclassified |
probably benign |
|
|
R9390:Amn1
|
UTSW |
6 |
149,084,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9565:Amn1
|
UTSW |
6 |
149,090,103 (GRCm39) |
start gained |
probably benign |
|
|
X0064:Amn1
|
UTSW |
6 |
149,072,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation