Incidental Mutation 'IGL02394:Gpr45'
ID293921
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr45
Ensembl Gene ENSMUSG00000041907
Gene NameG protein-coupled receptor 45
SynonymsPSP24alpha, 9230112G11Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL02394
Quality Score
Status
Chromosome1
Chromosomal Location42952872-43035456 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to G at 43030112 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000135986 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114761] [ENSMUST00000179766]
Predicted Effect probably benign
Transcript: ENSMUST00000114761
SMART Domains Protein: ENSMUSP00000110409
Gene: ENSMUSG00000041907

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 42 188 5.5e-9 PFAM
Pfam:7TM_GPCR_Srsx 45 340 1.9e-7 PFAM
Pfam:7tm_1 51 325 2.4e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179655
SMART Domains Protein: ENSMUSP00000136725
Gene: ENSMUSG00000096364

DomainStartEndE-ValueType
low complexity region 90 102 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179766
SMART Domains Protein: ENSMUSP00000135986
Gene: ENSMUSG00000041907

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 42 189 7.1e-9 PFAM
Pfam:7TM_GPCR_Srsx 45 340 1.9e-7 PFAM
Pfam:7tm_1 51 325 2.1e-51 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akt3 G A 1: 177,059,419 T288M probably damaging Het
Baat A T 4: 49,489,812 probably benign Het
Bclaf3 A G X: 159,555,489 Y444C probably damaging Het
Bcs1l A G 1: 74,590,300 T166A probably damaging Het
Cep135 C T 5: 76,631,471 T776I probably benign Het
Clasrp A G 7: 19,603,254 L12P probably damaging Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Cyp4f15 A G 17: 32,692,635 I164V possibly damaging Het
Eps15 T A 4: 109,312,965 L155M probably damaging Het
Fbxl20 G A 11: 98,113,256 R69W probably damaging Het
Galnt9 A G 5: 110,615,499 M457V probably damaging Het
Gemin2 T A 12: 59,014,056 probably null Het
Gm20521 T A 14: 54,898,042 Y175N probably damaging Het
Gm3298 T A 14: 5,018,778 C178S probably benign Het
Gpr37l1 T C 1: 135,167,008 N166S probably damaging Het
Gpr75 T C 11: 30,892,190 I365T possibly damaging Het
Gsdmc2 T C 15: 63,835,880 R22G probably damaging Het
Il23r T C 6: 67,466,272 probably benign Het
Itgam A T 7: 128,084,942 T340S probably benign Het
Klk1b24 A G 7: 44,191,870 D209G possibly damaging Het
Med13l A C 5: 118,748,833 T1600P probably benign Het
Muc16 G T 9: 18,498,700 H137Q probably damaging Het
Nin T C 12: 70,044,031 E870G probably damaging Het
Olfr1477 A G 19: 13,502,864 N174D probably damaging Het
Olfr360 A G 2: 37,068,485 Y60C probably damaging Het
Olfr811 A T 10: 129,802,313 F71I possibly damaging Het
Pkhd1 T C 1: 20,199,486 K3278R possibly damaging Het
Prlr A G 15: 10,328,578 N380D probably benign Het
Rpgr A C X: 10,166,217 S582R probably benign Het
Rph3a T C 5: 120,946,348 probably null Het
Setd5 A G 6: 113,110,898 H140R probably benign Het
Stoml3 C A 3: 53,498,119 probably benign Het
Teddm1a A C 1: 153,891,799 D3A probably benign Het
Tmem207 A G 16: 26,516,836 probably benign Het
Triml1 T A 8: 43,138,592 Q243L possibly damaging Het
Usp5 G A 6: 124,822,709 T274M probably damaging Het
Vav2 A G 2: 27,297,659 probably benign Het
Wdr5b A G 16: 36,042,263 N251D probably damaging Het
Wnk2 C A 13: 49,081,899 probably null Het
Other mutations in Gpr45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Gpr45 APN 1 43032292 missense possibly damaging 0.77
IGL01528:Gpr45 APN 1 43033223 missense probably benign 0.00
IGL01833:Gpr45 APN 1 43032242 missense probably benign
IGL02034:Gpr45 APN 1 43033318 makesense probably null
IGL02230:Gpr45 APN 1 43032656 missense probably damaging 1.00
IGL02279:Gpr45 APN 1 43032838 missense probably damaging 0.96
IGL02795:Gpr45 APN 1 43032493 missense possibly damaging 0.82
IGL02902:Gpr45 APN 1 43033211 missense possibly damaging 0.67
IGL03017:Gpr45 APN 1 43032356 missense possibly damaging 0.95
expansive UTSW 1 43032838 missense probably damaging 0.96
extensive UTSW 1 43033058 missense probably damaging 1.00
R0368:Gpr45 UTSW 1 43033016 missense probably damaging 1.00
R2964:Gpr45 UTSW 1 43032508 missense possibly damaging 0.87
R2965:Gpr45 UTSW 1 43032508 missense possibly damaging 0.87
R2966:Gpr45 UTSW 1 43032508 missense possibly damaging 0.87
R4551:Gpr45 UTSW 1 43032790 missense probably benign 0.00
R4681:Gpr45 UTSW 1 43032908 missense probably benign 0.00
R4821:Gpr45 UTSW 1 43030453 intron probably benign
R4966:Gpr45 UTSW 1 43033120 missense probably benign 0.00
R5054:Gpr45 UTSW 1 43032649 missense probably benign 0.38
R5319:Gpr45 UTSW 1 43032838 missense probably damaging 0.96
R5667:Gpr45 UTSW 1 43033058 missense probably damaging 1.00
R5671:Gpr45 UTSW 1 43033058 missense probably damaging 1.00
R7250:Gpr45 UTSW 1 43032371 missense probably damaging 1.00
Posted On2015-04-16