Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02441:Dpep2'

293991

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dpep2

Ensembl Gene

ENSMUSG00000115067

Gene Name

dipeptidase 2

Synonyms

F630103D06Rik, MBD-2

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.144) question?

Stock #

IGL02441

Quality Score

Status

Chromosome

Chromosomal Location

106711577-106732658 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 106711723 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 568 (A568V)

Ref Sequence

ENSEMBL: ENSMUSP00000154250 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000034373] [ENSMUST00000117555] [ENSMUST00000227363]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000034373
AA Change: A468V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000034373
Gene: ENSMUSG00000053687
AA Change: A468V

Domain	Start	End	E-Value	Type
signal peptide	1	31	N/A	INTRINSIC
Pfam:Peptidase_M19	80	401	3.4e-112	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000081998
AA Change: A577V

SMART Domains

Protein: ENSMUSP00000080659
Gene: ENSMUSG00000115067
AA Change: A577V

Domain	Start	End	E-Value	Type
low complexity region	97	113	N/A	INTRINSIC
Pfam:Peptidase_M19	166	501	1.2e-104	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000083297

Predicted Effect

probably benign
Transcript: ENSMUST00000117555
AA Change: A375V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000113877
Gene: ENSMUSG00000053687
AA Change: A375V

Domain	Start	End	E-Value	Type
Pfam:Peptidase_M19	1	308	5.7e-107	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000149057

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150001

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212917

Predicted Effect

probably benign
Transcript: ENSMUST00000227363
AA Change: A568V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alg8	C	T	7: 97,029,504 (GRCm39)	R179C	probably benign	Het
Als2	A	G	1: 59,254,631 (GRCm39)	M242T	probably damaging	Het
Atad1	C	T	19: 32,684,348 (GRCm39)	V17I	probably benign	Het
Bag4	A	G	8: 26,258,136 (GRCm39)	V397A	probably damaging	Het
Brd7	A	G	8: 89,070,218 (GRCm39)	V396A	probably damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cdhr4	T	A	9: 107,870,466 (GRCm39)	I123N	possibly damaging	Het
Cep68	A	G	11: 20,189,186 (GRCm39)	F609L	probably benign	Het
Clec3b	C	A	9: 122,980,178 (GRCm39)	P24T	possibly damaging	Het
Ctsg	T	A	14: 56,339,869 (GRCm39)	T9S	probably benign	Het
Dalrd3	A	T	9: 108,448,725 (GRCm39)		probably benign	Het
Dock6	A	T	9: 21,753,222 (GRCm39)	V286E	possibly damaging	Het
Dph5	A	C	3: 115,720,390 (GRCm39)	Q192P	possibly damaging	Het
Eppin	T	A	2: 164,433,698 (GRCm39)	R37*	probably null	Het
Esyt1	A	G	10: 128,348,293 (GRCm39)	L865P	possibly damaging	Het
Exoc6b	A	G	6: 84,981,990 (GRCm39)	L102P	probably damaging	Het
Foxo6	A	G	4: 120,125,232 (GRCm39)	I521T	possibly damaging	Het
Guca1a	A	T	17: 47,705,578 (GRCm39)		probably benign	Het
Hpx	A	G	7: 105,241,430 (GRCm39)	F327S	probably damaging	Het
Hspa12b	A	G	2: 130,980,515 (GRCm39)	M145V	probably null	Het
Hspa4	A	T	11: 53,161,809 (GRCm39)	S448T	probably benign	Het
Kbtbd6	T	C	14: 79,690,759 (GRCm39)	Y422H	probably benign	Het
Lama4	A	T	10: 38,937,441 (GRCm39)	D677V	probably benign	Het
Ldb1	C	T	19: 46,024,195 (GRCm39)	E111K	probably damaging	Het
Macf1	A	G	4: 123,281,029 (GRCm39)	S3823P	probably damaging	Het
Man1a2	G	A	3: 100,499,189 (GRCm39)	T415I	probably benign	Het
Map3k2	T	C	18: 32,333,099 (GRCm39)		probably benign	Het
Morn5	T	A	2: 35,945,038 (GRCm39)	Y87*	probably null	Het
Mpp3	T	C	11: 101,900,501 (GRCm39)	D326G	probably benign	Het
Mrgprx1	T	C	7: 47,671,336 (GRCm39)	H137R	probably benign	Het
Nav2	C	A	7: 49,102,260 (GRCm39)	P292T	probably damaging	Het
Nlrp2	C	A	7: 5,338,566 (GRCm39)		probably null	Het
Noxo1	G	A	17: 24,918,030 (GRCm39)	S112N	probably damaging	Het
Nudt9	G	T	5: 104,212,885 (GRCm39)	K319N	probably benign	Het
Or8b38	A	T	9: 37,973,233 (GRCm39)	I206L	probably benign	Het
Osbpl7	C	A	11: 96,958,528 (GRCm39)	Q728K	probably damaging	Het
Pcsk1	A	T	13: 75,280,282 (GRCm39)	E702D	probably benign	Het
Piezo2	T	C	18: 63,205,933 (GRCm39)	D1492G	probably damaging	Het
Plekhg1	A	G	10: 3,908,103 (GRCm39)	K1007E	possibly damaging	Het
Ppp6r3	G	A	19: 3,514,693 (GRCm39)	P141S	probably benign	Het
Prrt3	T	C	6: 113,473,977 (GRCm39)	T354A	probably damaging	Het
Ptk2	C	A	15: 73,192,675 (GRCm39)	W181L	probably benign	Het
Rif1	T	A	2: 51,995,527 (GRCm39)	H915Q	probably benign	Het
Selenbp2	G	T	3: 94,611,371 (GRCm39)	V361L	probably benign	Het
Slamf7	A	G	1: 171,468,625 (GRCm39)	L89P	probably damaging	Het
Slc6a21	G	A	7: 44,937,505 (GRCm39)	V599M	probably damaging	Het
Sltm	G	T	9: 70,494,467 (GRCm39)	S921I	probably damaging	Het
Smc4	C	A	3: 68,913,544 (GRCm39)	A44E	probably damaging	Het
Tdrd5	A	T	1: 156,087,513 (GRCm39)		probably benign	Het
Tead2	T	A	7: 44,866,845 (GRCm39)	I68N	probably damaging	Het
Tnks1bp1	T	A	2: 84,902,143 (GRCm39)	S1680T	probably damaging	Het
Topbp1	T	C	9: 103,197,438 (GRCm39)	V386A	possibly damaging	Het
Tpx2	C	A	2: 152,724,207 (GRCm39)	P328T	possibly damaging	Het
Ttn	T	A	2: 76,576,332 (GRCm39)	I24854F	probably damaging	Het
Zbtb11	G	A	16: 55,794,552 (GRCm39)	R43H	possibly damaging	Het
Zfp609	A	G	9: 65,610,611 (GRCm39)	L784S	possibly damaging	Het
Zfp703	T	C	8: 27,470,036 (GRCm39)	S567P	probably damaging	Het
Zfp750	A	G	11: 121,404,455 (GRCm39)	I140T	probably benign	Het

Other mutations in Dpep2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00590:Dpep2	APN	8	106,715,453 (GRCm39)	missense	probably damaging	1.00
IGL01160:Dpep2	APN	8	106,713,076 (GRCm39)	missense	possibly damaging	0.95
IGL02071:Dpep2	APN	8	106,711,776 (GRCm39)	missense	probably benign	0.01
IGL02517:Dpep2	APN	8	106,715,388 (GRCm39)	missense	probably damaging	1.00
IGL02836:Dpep2	APN	8	106,717,227 (GRCm39)	critical splice donor site	probably null
G1citation:Dpep2	UTSW	8	106,711,873 (GRCm39)	missense	probably benign	0.01
R0504:Dpep2	UTSW	8	106,716,620 (GRCm39)	missense	probably benign	0.29
R1866:Dpep2	UTSW	8	106,716,080 (GRCm39)	critical splice donor site	probably null
R1982:Dpep2	UTSW	8	106,716,087 (GRCm39)	nonsense	probably null
R2172:Dpep2	UTSW	8	106,715,630 (GRCm39)	missense	possibly damaging	0.88
R2399:Dpep2	UTSW	8	106,716,224 (GRCm39)	missense	probably damaging	1.00
R4369:Dpep2	UTSW	8	106,711,707 (GRCm39)	missense	probably benign	0.00
R4499:Dpep2	UTSW	8	106,712,114 (GRCm39)	missense	probably benign	0.32
R4500:Dpep2	UTSW	8	106,712,114 (GRCm39)	missense	probably benign	0.32
R4774:Dpep2	UTSW	8	106,717,388 (GRCm39)	missense	possibly damaging	0.48
R5114:Dpep2	UTSW	8	106,712,825 (GRCm39)	missense	probably damaging	1.00
R5727:Dpep2	UTSW	8	106,713,075 (GRCm39)	missense	probably benign	0.00
R6052:Dpep2	UTSW	8	106,717,270 (GRCm39)	missense	possibly damaging	0.91
R6177:Dpep2	UTSW	8	106,712,831 (GRCm39)	missense	probably damaging	1.00
R6658:Dpep2	UTSW	8	106,716,542 (GRCm39)	missense	probably benign	0.01
R6822:Dpep2	UTSW	8	106,711,873 (GRCm39)	missense	probably benign	0.01
R7854:Dpep2	UTSW	8	106,716,160 (GRCm39)	missense
R7866:Dpep2	UTSW	8	106,716,113 (GRCm39)	missense
R8169:Dpep2	UTSW	8	106,722,849 (GRCm39)	missense
R9047:Dpep2	UTSW	8	106,715,944 (GRCm39)	missense
R9203:Dpep2	UTSW	8	106,712,885 (GRCm39)	missense	probably damaging	1.00
R9222:Dpep2	UTSW	8	106,723,016 (GRCm39)	missense
V7732:Dpep2	UTSW	8	106,715,892 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16