Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02447:Zfp13'

294018

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp13

Ensembl Gene

ENSMUSG00000062012

Gene Name

zinc finger protein 13

Synonyms

Krox-8, Zfp-13

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

IGL02447

Quality Score

Status

Chromosome

Chromosomal Location

23794818-23818461 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23795072 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 493 (A493T)

Ref Sequence

ENSEMBL: ENSMUSP00000054595 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057029] [ENSMUST00000115516] [ENSMUST00000227952]

AlphaFold

P10754

Predicted Effect

probably benign
Transcript: ENSMUST00000057029
AA Change: A493T

PolyPhen 2 Score 0.053 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000054595
Gene: ENSMUSG00000062012
AA Change: A493T

Domain	Start	End	E-Value	Type
KRAB	117	179	7.54e-10	SMART
ZnF_C2H2	259	281	7.37e-4	SMART
ZnF_C2H2	287	309	1.2e-3	SMART
ZnF_C2H2	315	337	5.9e-3	SMART
ZnF_C2H2	343	365	1.26e-2	SMART
ZnF_C2H2	371	393	9.73e-4	SMART
ZnF_C2H2	399	421	2.12e-4	SMART
ZnF_C2H2	427	449	1.18e-2	SMART
ZnF_C2H2	455	477	6.52e-5	SMART
low complexity region	480	503	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000115516
AA Change: A500T

SMART Domains

Protein: ENSMUSP00000111178
Gene: ENSMUSG00000062012
AA Change: A500T

Domain	Start	End	E-Value	Type
KRAB	124	186	7.54e-10	SMART
ZnF_C2H2	266	288	7.37e-4	SMART
ZnF_C2H2	294	316	1.2e-3	SMART
ZnF_C2H2	322	344	5.9e-3	SMART
ZnF_C2H2	350	372	1.26e-2	SMART
ZnF_C2H2	378	400	9.73e-4	SMART
ZnF_C2H2	406	428	2.12e-4	SMART
ZnF_C2H2	434	456	1.18e-2	SMART
ZnF_C2H2	462	484	6.52e-5	SMART
low complexity region	487	510	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226550

Predicted Effect

probably benign
Transcript: ENSMUST00000227952

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000228942

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm4	T	A	4: 144,401,269 (GRCm39)	I72F	probably benign	Het
Abhd18	T	A	3: 40,888,208 (GRCm39)	F351I	probably benign	Het
Agfg1	T	A	1: 82,859,944 (GRCm39)		probably benign	Het
Antxr2	C	T	5: 98,178,267 (GRCm39)	V48I	possibly damaging	Het
Bcl9l	T	C	9: 44,418,631 (GRCm39)	M823T	probably benign	Het
Card11	G	A	5: 140,892,679 (GRCm39)	H129Y	possibly damaging	Het
Ccr1	A	T	9: 123,763,753 (GRCm39)	V259E	probably benign	Het
Cdk13	G	T	13: 17,947,001 (GRCm39)	P586T	probably benign	Het
Cep295	C	T	9: 15,243,807 (GRCm39)	V1502I	probably damaging	Het
Csnk1g3	T	C	18: 54,028,942 (GRCm39)	S32P	probably benign	Het
Dpysl4	G	A	7: 138,678,516 (GRCm39)	R492Q	probably damaging	Het
Duox2	A	G	2: 122,127,949 (GRCm39)	L78P	probably damaging	Het
Gm7361	T	C	5: 26,462,853 (GRCm39)	S32P	probably benign	Het
Grip1	T	A	10: 119,855,976 (GRCm39)	V234E	probably damaging	Het
Herc1	A	T	9: 66,404,610 (GRCm39)	I4477L	possibly damaging	Het
Il18r1	G	A	1: 40,537,497 (GRCm39)		probably null	Het
Itpkb	A	G	1: 180,248,919 (GRCm39)		probably benign	Het
Jag2	T	C	12: 112,876,232 (GRCm39)	Y799C	probably damaging	Het
Jak2	A	G	19: 29,277,014 (GRCm39)	K857R	probably damaging	Het
Kbtbd12	A	T	6: 88,595,676 (GRCm39)	S51R	probably damaging	Het
Kcnc2	T	G	10: 112,291,851 (GRCm39)	D346E	probably damaging	Het
Kcnh1	T	A	1: 191,907,224 (GRCm39)	M92K	possibly damaging	Het
Kcnk1	A	G	8: 126,751,819 (GRCm39)	I142V	probably damaging	Het
Lsm11	T	C	11: 45,828,191 (GRCm39)	N196D	probably damaging	Het
Mpeg1	G	T	19: 12,440,156 (GRCm39)	C538F	probably damaging	Het
Nrap	G	A	19: 56,333,951 (GRCm39)	Q969*	probably null	Het
Nt5el	A	T	13: 105,236,967 (GRCm39)	S73C	probably damaging	Het
Nup205	T	C	6: 35,204,511 (GRCm39)		probably null	Het
Pdcd5	A	G	7: 35,342,110 (GRCm39)	V166A	possibly damaging	Het
Plcb2	A	T	2: 118,543,636 (GRCm39)	I745N	probably damaging	Het
Ptprt	T	C	2: 162,120,027 (GRCm39)	T147A	probably benign	Het
Rbp3	A	T	14: 33,676,460 (GRCm39)	D136V	probably damaging	Het
Ripor3	G	T	2: 167,834,750 (GRCm39)	T247N	probably damaging	Het
Sgcd	A	C	11: 46,870,082 (GRCm39)		probably benign	Het
Slc26a6	T	C	9: 108,734,251 (GRCm39)	Y211H	probably benign	Het
Slc37a3	T	A	6: 39,314,129 (GRCm39)	E494D	probably benign	Het
Smc5	T	C	19: 23,234,856 (GRCm39)	E326G	probably benign	Het
Tctn2	T	C	5: 124,753,316 (GRCm39)		noncoding transcript	Het
Tk2	T	A	8: 104,967,770 (GRCm39)	N93I	probably damaging	Het
Tmed6	A	G	8: 107,792,240 (GRCm39)	F2L	possibly damaging	Het
Tox3	A	G	8: 90,984,781 (GRCm39)		probably benign	Het
Tspan9	T	C	6: 127,941,401 (GRCm39)	Y237C	probably benign	Het
Ubqlnl	A	G	7: 103,797,856 (GRCm39)	L547P	probably damaging	Het
Uggt1	T	C	1: 36,189,223 (GRCm39)	D1421G	probably damaging	Het
Unc80	T	A	1: 66,542,703 (GRCm39)	I319K	possibly damaging	Het
Vac14	A	G	8: 111,380,260 (GRCm39)	D441G	probably benign	Het
Vamp8	C	T	6: 72,365,316 (GRCm39)	V5M	probably damaging	Het
Yeats2	T	A	16: 20,012,429 (GRCm39)	H560Q	probably benign	Het
Zfp773	G	T	7: 7,139,655 (GRCm39)		probably benign	Het

Other mutations in Zfp13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02236:Zfp13	APN	17	23,799,739 (GRCm39)	splice site	probably benign
IGL02449:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02450:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02466:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02468:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02471:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02473:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02474:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02475:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02491:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02511:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL02558:Zfp13	APN	17	23,795,072 (GRCm39)	missense	probably benign	0.05
IGL03030:Zfp13	APN	17	23,799,819 (GRCm39)	missense	probably benign	0.01
IGL03388:Zfp13	APN	17	23,795,888 (GRCm39)	missense	probably benign	0.00
R0053:Zfp13	UTSW	17	23,795,122 (GRCm39)	missense	probably damaging	1.00
R0053:Zfp13	UTSW	17	23,795,122 (GRCm39)	missense	probably damaging	1.00
R1514:Zfp13	UTSW	17	23,795,386 (GRCm39)	missense	probably damaging	1.00
R2420:Zfp13	UTSW	17	23,795,186 (GRCm39)	missense	probably damaging	1.00
R3433:Zfp13	UTSW	17	23,795,602 (GRCm39)	missense	probably damaging	0.99
R4458:Zfp13	UTSW	17	23,800,150 (GRCm39)	missense	probably benign	0.01
R4650:Zfp13	UTSW	17	23,799,112 (GRCm39)	missense	probably damaging	1.00
R4824:Zfp13	UTSW	17	23,795,797 (GRCm39)	missense	possibly damaging	0.95
R5088:Zfp13	UTSW	17	23,796,035 (GRCm39)	nonsense	probably null
R5110:Zfp13	UTSW	17	23,799,834 (GRCm39)	missense	probably benign	0.02
R5384:Zfp13	UTSW	17	23,800,156 (GRCm39)	missense	probably damaging	1.00
R7302:Zfp13	UTSW	17	23,800,036 (GRCm39)	missense	probably damaging	1.00
R8443:Zfp13	UTSW	17	23,795,866 (GRCm39)	missense	probably benign
R9728:Zfp13	UTSW	17	23,799,788 (GRCm39)	missense	possibly damaging	0.80

Posted On

2015-04-16