Incidental Mutation 'IGL02449:Ly6k'
ID 294091
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ly6k
Ensembl Gene ENSMUSG00000044678
Gene Name lymphocyte antigen 6 family member K
Synonyms 3110035B01Rik, 2410015A16Rik, mLy-6K
Accession Numbers
Essential gene? Probably non essential (E-score: 0.019) question?
Stock # IGL02449
Quality Score
Status
Chromosome 15
Chromosomal Location 74668723-74671817 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 74668934 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 115 (D115A)
Ref Sequence ENSEMBL: ENSMUSP00000132129 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060301] [ENSMUST00000168815]
AlphaFold Q9CWP4
Predicted Effect probably benign
Transcript: ENSMUST00000060301
AA Change: D115A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000052599
Gene: ENSMUSG00000044678
AA Change: D115A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 21 117 2.54e-7 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163707
Predicted Effect probably benign
Transcript: ENSMUST00000168815
AA Change: D115A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000132129
Gene: ENSMUSG00000044678
AA Change: D115A

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
LU 21 117 2.54e-7 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with impaired sperm migration into the oviduct. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,440,908 (GRCm39) probably null Het
Akap6 A G 12: 53,186,971 (GRCm39) T1462A probably damaging Het
Arl6ip6 T C 2: 53,082,538 (GRCm39) probably benign Het
Ascc3 A T 10: 50,576,695 (GRCm39) Q883H probably benign Het
Atp11a T A 8: 12,807,358 (GRCm39) probably null Het
Cds1 G A 5: 101,963,794 (GRCm39) G371D probably damaging Het
Col12a1 A G 9: 79,548,751 (GRCm39) L2198P probably damaging Het
Cyp2d22 C T 15: 82,257,442 (GRCm39) G241D probably benign Het
Dapk1 T C 13: 60,867,584 (GRCm39) probably benign Het
Dera T A 6: 137,757,815 (GRCm39) probably null Het
Efcab6 A G 15: 83,894,234 (GRCm39) V186A probably benign Het
Gm9637 T A 14: 19,402,436 (GRCm38) noncoding transcript Het
Gpr180 T C 14: 118,397,532 (GRCm39) L342P probably damaging Het
Heg1 T C 16: 33,559,095 (GRCm39) probably null Het
Kcnab2 C A 4: 152,496,441 (GRCm39) probably null Het
Lax1 A G 1: 133,607,874 (GRCm39) V289A probably damaging Het
Mcc A C 18: 44,593,025 (GRCm39) I670S probably benign Het
Mpdz C A 4: 81,247,659 (GRCm39) probably null Het
Mrgprb8 T A 7: 48,038,431 (GRCm39) L34* probably null Het
Mtor T A 4: 148,618,378 (GRCm39) H1730Q possibly damaging Het
Muc4 C T 16: 32,576,503 (GRCm39) probably benign Het
Myh8 T C 11: 67,185,440 (GRCm39) probably null Het
Naip5 A T 13: 100,358,683 (GRCm39) V851E probably benign Het
Neb T C 2: 52,091,918 (GRCm39) I1277V probably benign Het
Nlrp9a T C 7: 26,264,396 (GRCm39) M683T probably benign Het
Npr2 A G 4: 43,646,641 (GRCm39) Y663C probably damaging Het
Padi3 C T 4: 140,517,023 (GRCm39) probably null Het
Pclo A G 5: 14,565,357 (GRCm39) D41G probably damaging Het
Pds5a A T 5: 65,776,353 (GRCm39) N80K probably damaging Het
Plec C T 15: 76,070,963 (GRCm39) D812N possibly damaging Het
Psg20 A T 7: 18,418,333 (GRCm39) probably benign Het
Ptch2 C A 4: 116,965,380 (GRCm39) L322I possibly damaging Het
Ptprv T C 1: 135,039,074 (GRCm39) noncoding transcript Het
Scn2b A G 9: 45,036,812 (GRCm39) K107E probably damaging Het
Slc24a4 A C 12: 102,193,341 (GRCm39) I226L probably benign Het
Spink4 A G 4: 40,929,190 (GRCm39) M72V probably benign Het
Supt16 A T 14: 52,411,263 (GRCm39) M676K possibly damaging Het
Svep1 A C 4: 58,070,296 (GRCm39) C2497G possibly damaging Het
Tenm2 T A 11: 35,914,449 (GRCm39) T2362S probably damaging Het
Tgm3 G T 2: 129,880,529 (GRCm39) probably null Het
Trpa1 T A 1: 14,968,381 (GRCm39) T462S probably damaging Het
Ucp2 G A 7: 100,148,017 (GRCm39) V237M probably damaging Het
Vmn2r53 C A 7: 12,316,288 (GRCm39) L510F probably damaging Het
Zan G A 5: 137,387,589 (GRCm39) T4874M unknown Het
Zfp13 C T 17: 23,795,072 (GRCm39) A493T probably benign Het
Zfp974 T A 7: 27,611,152 (GRCm39) Y191F probably benign Het
Other mutations in Ly6k
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1926:Ly6k UTSW 15 74,669,051 (GRCm39) missense probably benign 0.00
R2238:Ly6k UTSW 15 74,669,018 (GRCm39) missense probably benign 0.00
R5901:Ly6k UTSW 15 74,670,429 (GRCm39) missense probably benign 0.01
R6963:Ly6k UTSW 15 74,670,431 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16