Incidental Mutation 'IGL02392:Gpr146'
ID294263
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr146
Ensembl Gene ENSMUSG00000044197
Gene NameG protein-coupled receptor 146
SynonymsPGR8
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02392
Quality Score
Status
Chromosome5
Chromosomal Location139377697-139396415 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 139392778 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 112 (S112P)
Ref Sequence ENSEMBL: ENSMUSP00000098083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051293] [ENSMUST00000066052] [ENSMUST00000100514] [ENSMUST00000138631] [ENSMUST00000198474]
Predicted Effect probably damaging
Transcript: ENSMUST00000051293
AA Change: S112P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000049707
Gene: ENSMUSG00000044197
AA Change: S112P

DomainStartEndE-ValueType
low complexity region 21 36 N/A INTRINSIC
Pfam:7tm_1 43 294 2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000066052
SMART Domains Protein: ENSMUSP00000069230
Gene: ENSMUSG00000053553

DomainStartEndE-ValueType
low complexity region 54 77 N/A INTRINSIC
Pfam:DUF2373 103 165 3e-26 PFAM
low complexity region 184 194 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000100514
AA Change: S112P

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000098083
Gene: ENSMUSG00000044197
AA Change: S112P

DomainStartEndE-ValueType
low complexity region 21 36 N/A INTRINSIC
Pfam:7tm_1 43 294 1.6e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138631
SMART Domains Protein: ENSMUSP00000119464
Gene: ENSMUSG00000044197

DomainStartEndE-ValueType
SCOP:d1l9ha_ 26 80 3e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196267
Predicted Effect probably benign
Transcript: ENSMUST00000198474
SMART Domains Protein: ENSMUSP00000142949
Gene: ENSMUSG00000053553

DomainStartEndE-ValueType
low complexity region 54 77 N/A INTRINSIC
Pfam:DUF2373 102 141 9e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp2a3 C A 11: 72,975,339 H262N probably benign Het
C2cd6 T C 1: 59,094,838 N8S probably benign Het
Cdh8 G A 8: 99,030,755 T737M probably damaging Het
Celsr3 T C 9: 108,834,721 probably benign Het
Cenph T A 13: 100,772,761 Q46L probably benign Het
Dlg5 A G 14: 24,150,209 C1395R probably damaging Het
Dnah8 C T 17: 30,818,051 probably benign Het
Dolk T C 2: 30,285,728 N102D probably benign Het
Efr3b C T 12: 3,983,391 V139I probably benign Het
Farp2 G A 1: 93,577,650 R368Q probably damaging Het
Fermt3 A T 19: 7,018,815 M4K probably benign Het
Fndc8 A C 11: 82,898,603 T196P probably damaging Het
Galc G A 12: 98,207,413 T630I probably damaging Het
Gm21970 T G 16: 91,414,657 S128A possibly damaging Het
Grip2 A G 6: 91,787,295 S51P probably damaging Het
Htra2 G T 6: 83,054,299 T43N possibly damaging Het
Lnpep T C 17: 17,579,183 Y70C possibly damaging Het
Med17 G A 9: 15,277,667 R101* probably null Het
Mtdh A T 15: 34,099,577 N158Y probably damaging Het
Neo1 A T 9: 58,925,811 H550Q possibly damaging Het
Olfr480 A C 7: 108,066,503 F68L probably benign Het
Olfr93 C T 17: 37,151,088 V295I probably benign Het
Pex1 C T 5: 3,605,952 Q260* probably null Het
Pex6 T C 17: 46,723,499 V758A probably damaging Het
Ppil2 T C 16: 17,088,838 T500A probably benign Het
Qsox1 T C 1: 155,812,600 E67G probably damaging Het
Rimbp2 C T 5: 128,771,797 S895N probably benign Het
Rnls A G 19: 33,202,612 V28A possibly damaging Het
Spidr T C 16: 15,889,630 *934W probably null Het
Spta1 A T 1: 174,218,814 M1654L probably damaging Het
Srbd1 C A 17: 85,988,373 V870F probably benign Het
Suco A T 1: 161,834,567 M765K probably benign Het
Taok1 A G 11: 77,549,352 Y610H probably benign Het
Thbs1 A G 2: 118,114,660 N238S probably benign Het
Them7 T A 2: 105,378,875 L180* probably null Het
Trim45 A G 3: 100,925,305 I285V probably benign Het
Trim66 T C 7: 109,460,274 K921R probably benign Het
Ttn A G 2: 76,771,543 S10265P probably damaging Het
Vgll3 A T 16: 65,815,670 Y13F probably damaging Het
Ylpm1 T A 12: 85,014,957 M544K unknown Het
Zmym1 T A 4: 127,048,463 S711C probably damaging Het
Other mutations in Gpr146
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01355:Gpr146 APN 5 139378904 intron probably benign
IGL02152:Gpr146 APN 5 139392712 missense probably damaging 1.00
IGL02369:Gpr146 APN 5 139392688 missense probably benign 0.00
IGL02828:Gpr146 APN 5 139392821 missense probably damaging 0.97
IGL03095:Gpr146 APN 5 139392950 missense probably benign 0.11
R0360:Gpr146 UTSW 5 139379178 intron probably benign
R0364:Gpr146 UTSW 5 139379178 intron probably benign
R0746:Gpr146 UTSW 5 139393222 missense probably damaging 1.00
R1446:Gpr146 UTSW 5 139393422 missense probably benign 0.00
R1507:Gpr146 UTSW 5 139393369 missense probably benign
R1758:Gpr146 UTSW 5 139393382 missense probably benign 0.34
R2032:Gpr146 UTSW 5 139379147 intron probably benign
R6513:Gpr146 UTSW 5 139392818 missense probably damaging 1.00
R6797:Gpr146 UTSW 5 139393040 missense possibly damaging 0.79
X0064:Gpr146 UTSW 5 139378909 intron probably benign
Posted On2015-04-16