Incidental Mutation 'IGL00956:Iigp1c'
| ID |
29435 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Iigp1c
|
| Ensembl Gene |
ENSMUSG00000073555 |
| Gene Name |
interferon inducible GTPase 1C |
| Synonyms |
Gm4951 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00956
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
18 |
| Chromosomal Location |
60345152-60380892 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 60379262 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Proline
at position 266
(T266P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000031549
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031549]
|
| AlphaFold |
Q3UED7 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031549
AA Change: T266P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000031549
Gene: ENSMUSG00000073555
AA Change: T266P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IIGP
|
34 |
402 |
4.8e-157 |
PFAM |
|
Pfam:MMR_HSR1
|
70 |
198 |
2.8e-8 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 20 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Cdhr2 |
G |
T |
13: 54,866,156 (GRCm39) |
V319F |
probably damaging |
Het |
| Chac2 |
A |
G |
11: 30,936,225 (GRCm39) |
S8P |
probably damaging |
Het |
| Clec4b2 |
T |
A |
6: 123,179,110 (GRCm39) |
Y137* |
probably null |
Het |
| Dbt |
G |
A |
3: 116,339,763 (GRCm39) |
G384S |
probably benign |
Het |
| Duox1 |
G |
T |
2: 122,153,787 (GRCm39) |
R370L |
probably benign |
Het |
| Hnrnpm |
C |
A |
17: 33,868,876 (GRCm39) |
R517L |
probably damaging |
Het |
| Iqschfp |
C |
A |
3: 68,533,184 (GRCm39) |
A255E |
probably damaging |
Het |
| Kcnh7 |
G |
A |
2: 62,607,983 (GRCm39) |
R533C |
probably damaging |
Het |
| Nckap5 |
A |
C |
1: 125,952,755 (GRCm39) |
L1266V |
probably damaging |
Het |
| Opcml |
A |
G |
9: 28,586,624 (GRCm39) |
N121S |
possibly damaging |
Het |
| Rad54b |
T |
A |
4: 11,597,833 (GRCm39) |
N239K |
probably damaging |
Het |
| Rp1 |
T |
C |
1: 4,422,435 (GRCm39) |
D215G |
probably damaging |
Het |
| Scaf8 |
T |
C |
17: 3,221,422 (GRCm39) |
I303T |
unknown |
Het |
| Slc35f3 |
G |
A |
8: 127,108,963 (GRCm39) |
A171T |
probably damaging |
Het |
| Tlk2 |
T |
A |
11: 105,138,418 (GRCm39) |
I322N |
probably benign |
Het |
| Tubb4a |
A |
G |
17: 57,393,072 (GRCm39) |
V66A |
probably benign |
Het |
| Ubxn2a |
C |
T |
12: 4,933,956 (GRCm39) |
A152T |
probably benign |
Het |
| Ush2a |
A |
T |
1: 188,485,719 (GRCm39) |
D2943V |
probably damaging |
Het |
| Wdr62 |
A |
G |
7: 29,960,764 (GRCm39) |
V55A |
probably damaging |
Het |
| Zfp609 |
A |
G |
9: 65,610,045 (GRCm39) |
Y973H |
probably benign |
Het |
|
| Other mutations in Iigp1c |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00717:Iigp1c
|
APN |
18 |
60,379,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00807:Iigp1c
|
APN |
18 |
60,378,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01017:Iigp1c
|
APN |
18 |
60,378,508 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01929:Iigp1c
|
APN |
18 |
60,379,554 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02267:Iigp1c
|
APN |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02276:Iigp1c
|
APN |
18 |
60,379,151 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02499:Iigp1c
|
APN |
18 |
60,378,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02538:Iigp1c
|
APN |
18 |
60,378,944 (GRCm39) |
nonsense |
probably null |
|
|
IGL03139:Iigp1c
|
APN |
18 |
60,379,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03209:Iigp1c
|
APN |
18 |
60,379,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Iigp1c
|
APN |
18 |
60,378,548 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03325:Iigp1c
|
APN |
18 |
60,378,883 (GRCm39) |
nonsense |
probably null |
|
|
Carboniferous
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Oily
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Iigp1c
|
UTSW |
18 |
60,378,489 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2046:Iigp1c
|
UTSW |
18 |
60,378,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2296:Iigp1c
|
UTSW |
18 |
60,378,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4583:Iigp1c
|
UTSW |
18 |
60,379,152 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5500:Iigp1c
|
UTSW |
18 |
60,379,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5532:Iigp1c
|
UTSW |
18 |
60,379,142 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5938:Iigp1c
|
UTSW |
18 |
60,378,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6446:Iigp1c
|
UTSW |
18 |
60,378,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7191:Iigp1c
|
UTSW |
18 |
60,379,329 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7238:Iigp1c
|
UTSW |
18 |
60,379,355 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7443:Iigp1c
|
UTSW |
18 |
60,379,122 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9261:Iigp1c
|
UTSW |
18 |
60,353,820 (GRCm39) |
intron |
probably benign |
|
|
R9650:Iigp1c
|
UTSW |
18 |
60,379,470 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1177:Iigp1c
|
UTSW |
18 |
60,379,368 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Posted On |
2013-04-17 |
Incidental Mutation