Incidental Mutation 'IGL02412:Or6n1'
ID 294394
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or6n1
Ensembl Gene ENSMUSG00000049528
Gene Name olfactory receptor family 6 subfamily N member 1
Synonyms Olfr429, GA_x6K02T2P20D-21090094-21089156, MOR105-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # IGL02412
Quality Score
Status
Chromosome 1
Chromosomal Location 173916604-173917546 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 173916809 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 68 (F68L)
Ref Sequence ENSEMBL: ENSMUSP00000149257 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060693] [ENSMUST00000216346]
AlphaFold Q7TRW1
Predicted Effect probably benign
Transcript: ENSMUST00000060693
AA Change: F68L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000051323
Gene: ENSMUSG00000049528
AA Change: F68L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.2e-65 PFAM
Pfam:7tm_1 41 290 1.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193320
AA Change: F68L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000142323
Gene: ENSMUSG00000049528
AA Change: F68L

DomainStartEndE-ValueType
low complexity region 25 40 N/A INTRINSIC
Pfam:7tm_1 41 290 8.9e-31 PFAM
Pfam:7tm_4 139 283 6.7e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216346
AA Change: F68L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alms1 T A 6: 85,605,854 (GRCm39) F2032L possibly damaging Het
Caps2 T C 10: 112,039,941 (GRCm39) probably null Het
Ccdc88b A T 19: 6,824,012 (GRCm39) F1414I probably damaging Het
Cr1l T G 1: 194,797,080 (GRCm39) Y319S probably damaging Het
Cr1l C T 1: 194,797,074 (GRCm39) G283E probably damaging Het
Csmd2 G A 4: 128,407,165 (GRCm39) probably benign Het
Dhx37 T A 5: 125,508,692 (GRCm39) K81M probably damaging Het
Dzip3 T A 16: 48,778,820 (GRCm39) M326L probably benign Het
Exosc10 A G 4: 148,652,849 (GRCm39) D488G probably benign Het
Gm2058 G A 7: 39,238,457 (GRCm39) noncoding transcript Het
Gm43638 T A 5: 87,633,995 (GRCm39) Q204L possibly damaging Het
Gm4847 T C 1: 166,469,307 (GRCm39) D119G probably damaging Het
Gnb3 A C 6: 124,814,425 (GRCm39) M120R probably benign Het
Il16 A C 7: 83,301,899 (GRCm39) D74E probably benign Het
Kpna1 T C 16: 35,851,561 (GRCm39) F382L probably benign Het
Krt33a G T 11: 99,902,805 (GRCm39) Q340K probably benign Het
Lrrc17 T A 5: 21,765,877 (GRCm39) S120T possibly damaging Het
Mapk3 C A 7: 126,362,210 (GRCm39) Y56* probably null Het
Mfhas1 C T 8: 36,055,969 (GRCm39) A148V probably benign Het
Npr2 A G 4: 43,647,005 (GRCm39) I713V probably damaging Het
Obp1a T A X: 77,131,980 (GRCm39) Y108F probably damaging Het
Or51f1d A T 7: 102,701,359 (GRCm39) M285L probably benign Het
Or5ac21 T A 16: 59,123,555 (GRCm39) L13H probably damaging Het
Or7e178 T A 9: 20,225,935 (GRCm39) S86C probably benign Het
Pias1 A T 9: 62,800,421 (GRCm39) N430K probably benign Het
Ralgapa2 G T 2: 146,254,052 (GRCm39) A836D probably damaging Het
Rftn2 T C 1: 55,245,497 (GRCm39) E238G probably benign Het
Samt4 T G X: 153,267,118 (GRCm39) S86A probably damaging Het
Setd2 T C 9: 110,379,842 (GRCm39) M1219T probably benign Het
Sh3pxd2b T A 11: 32,337,992 (GRCm39) D99E probably damaging Het
Sh3rf1 A T 8: 61,825,723 (GRCm39) T573S probably benign Het
Sugct A G 13: 17,837,386 (GRCm39) W82R probably damaging Het
Syt4 T G 18: 31,576,896 (GRCm39) K153Q probably benign Het
Tbrg1 T C 9: 37,563,908 (GRCm39) probably null Het
Tex36 C T 7: 133,189,137 (GRCm39) R145K probably benign Het
Tfap2b A T 1: 19,289,427 (GRCm39) D166V probably damaging Het
Trhde T C 10: 114,322,830 (GRCm39) Y694C probably damaging Het
Trpc1 G A 9: 95,618,914 (GRCm39) L146F probably damaging Het
Ttc29 G A 8: 79,003,569 (GRCm39) E262K possibly damaging Het
Ttn A T 2: 76,547,293 (GRCm39) I32251N probably damaging Het
Ttn G T 2: 76,612,691 (GRCm39) D17129E probably benign Het
Ucma T A 2: 4,981,636 (GRCm39) I47N probably damaging Het
Vmn1r13 A T 6: 57,187,474 (GRCm39) K211M possibly damaging Het
Vmn2r95 A C 17: 18,660,218 (GRCm39) H210P probably damaging Het
Xpc T C 6: 91,476,767 (GRCm39) E444G probably benign Het
Yy1 T C 12: 108,760,023 (GRCm39) probably benign Het
Zfp217 A G 2: 169,954,422 (GRCm39) probably benign Het
Zfp318 T A 17: 46,720,043 (GRCm39) Y1080* probably null Het
Other mutations in Or6n1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01626:Or6n1 APN 1 173,917,122 (GRCm39) missense probably damaging 1.00
IGL01868:Or6n1 APN 1 173,916,936 (GRCm39) missense possibly damaging 0.83
IGL01972:Or6n1 APN 1 173,916,987 (GRCm39) missense probably damaging 0.99
IGL02628:Or6n1 APN 1 173,916,756 (GRCm39) missense probably benign
IGL02861:Or6n1 APN 1 173,916,602 (GRCm39) utr 5 prime probably benign
IGL03404:Or6n1 APN 1 173,917,464 (GRCm39) missense probably damaging 1.00
R0267:Or6n1 UTSW 1 173,916,732 (GRCm39) missense probably damaging 1.00
R0357:Or6n1 UTSW 1 173,916,675 (GRCm39) missense possibly damaging 0.71
R1499:Or6n1 UTSW 1 173,916,813 (GRCm39) nonsense probably null
R2051:Or6n1 UTSW 1 173,916,785 (GRCm39) missense possibly damaging 0.95
R4706:Or6n1 UTSW 1 173,917,268 (GRCm39) missense probably damaging 1.00
R4820:Or6n1 UTSW 1 173,916,742 (GRCm39) missense possibly damaging 0.95
R5439:Or6n1 UTSW 1 173,917,541 (GRCm39) missense probably benign 0.01
R5538:Or6n1 UTSW 1 173,917,544 (GRCm39) makesense probably null
R5907:Or6n1 UTSW 1 173,916,785 (GRCm39) missense probably benign 0.08
R6932:Or6n1 UTSW 1 173,917,316 (GRCm39) missense probably damaging 0.96
R7808:Or6n1 UTSW 1 173,917,417 (GRCm39) nonsense probably null
R8040:Or6n1 UTSW 1 173,916,723 (GRCm39) missense possibly damaging 0.68
R8467:Or6n1 UTSW 1 173,917,007 (GRCm39) missense probably benign 0.00
R9124:Or6n1 UTSW 1 173,917,341 (GRCm39) missense probably damaging 1.00
R9797:Or6n1 UTSW 1 173,917,356 (GRCm39) missense possibly damaging 0.65
Posted On 2015-04-16