Incidental Mutation 'IGL02458:Dpp10'
ID 294480
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpp10
Ensembl Gene ENSMUSG00000036815
Gene Name dipeptidylpeptidase 10
Synonyms 6430601K09Rik, DPRP3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02458
Quality Score
Status
Chromosome 1
Chromosomal Location 123259871-124773774 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123269418 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 664 (I664V)
Ref Sequence ENSEMBL: ENSMUSP00000108225 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112603] [ENSMUST00000112606]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000112603
AA Change: I653V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000108222
Gene: ENSMUSG00000036815
AA Change: I653V

DomainStartEndE-ValueType
low complexity region 10 25 N/A INTRINSIC
Pfam:DPPIV_N 83 450 4.9e-118 PFAM
Pfam:Peptidase_S9 530 734 6.4e-47 PFAM
Pfam:DLH 556 711 1.4e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000112606
AA Change: I664V

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000108225
Gene: ENSMUSG00000036815
AA Change: I664V

DomainStartEndE-ValueType
transmembrane domain 38 60 N/A INTRINSIC
low complexity region 64 79 N/A INTRINSIC
Pfam:DPPIV_N 137 504 4.4e-115 PFAM
Pfam:Peptidase_S9 584 788 8.6e-48 PFAM
Pfam:DLH 604 774 1.1e-7 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 A T 8: 41,206,844 (GRCm39) I37L probably benign Het
Alpk1 A G 3: 127,474,968 (GRCm39) probably null Het
Ankrd33 T C 15: 101,014,488 (GRCm39) F8L probably damaging Het
Avil A G 10: 126,852,222 (GRCm39) K669R probably benign Het
Bcor G T X: 11,914,749 (GRCm39) L1165I probably damaging Het
C7 A G 15: 5,088,871 (GRCm39) probably benign Het
Cc2d2a A G 5: 43,875,896 (GRCm39) I958V probably benign Het
Cenpe A T 3: 134,935,869 (GRCm39) K435* probably null Het
Chrna7 G A 7: 62,755,842 (GRCm39) L235F probably damaging Het
Col6a3 C A 1: 90,706,919 (GRCm39) V2065L unknown Het
Copb1 A T 7: 113,846,020 (GRCm39) N183K probably benign Het
Cpn2 G A 16: 30,079,653 (GRCm39) A16V probably benign Het
Cul1 A G 6: 47,502,542 (GRCm39) K769E possibly damaging Het
Deup1 C T 9: 15,503,656 (GRCm39) V302M probably benign Het
Dnah17 T C 11: 117,927,176 (GRCm39) K3871E probably damaging Het
Dnah6 A G 6: 73,004,431 (GRCm39) V3844A probably benign Het
Dnah7a A T 1: 53,657,487 (GRCm39) L763* probably null Het
Donson A T 16: 91,478,064 (GRCm39) W461R probably damaging Het
Dusp8 T A 7: 141,636,484 (GRCm39) T369S probably benign Het
Dync2h1 A T 9: 7,117,422 (GRCm39) L56Q probably damaging Het
Ecd A T 14: 20,374,545 (GRCm39) S532T probably benign Het
Frg2f1 G A 4: 119,388,154 (GRCm39) T115I probably damaging Het
Gpatch2l A G 12: 86,335,735 (GRCm39) probably benign Het
Gtf3c2 T A 5: 31,316,867 (GRCm39) probably null Het
Haghl T C 17: 26,002,470 (GRCm39) probably benign Het
Hoxc8 A T 15: 102,901,181 (GRCm39) N208I probably damaging Het
Igf2 T C 7: 142,207,785 (GRCm39) D115G probably benign Het
Jag2 T A 12: 112,879,613 (GRCm39) D385V probably damaging Het
Laptm4b A G 15: 34,258,888 (GRCm39) H54R probably benign Het
Lrp2 A G 2: 69,352,117 (GRCm39) S640P probably damaging Het
Map3k8 A C 18: 4,334,660 (GRCm39) V328G probably damaging Het
Mfsd13a A G 19: 46,360,686 (GRCm39) E388G probably damaging Het
Ms4a13 G A 19: 11,149,292 (GRCm39) T168I probably benign Het
Mtg1 C A 7: 139,730,085 (GRCm39) Q294K probably benign Het
Myh3 C T 11: 66,987,766 (GRCm39) A1413V possibly damaging Het
Neo1 A T 9: 58,801,150 (GRCm39) probably benign Het
Ogfod3 T C 11: 121,091,749 (GRCm39) E119G probably benign Het
Or10ak9 A G 4: 118,726,497 (GRCm39) N173S possibly damaging Het
Or2t49 A T 11: 58,393,073 (GRCm39) M109K probably benign Het
Or4a77 A G 2: 89,487,692 (GRCm39) L31P probably damaging Het
Or5ak20 G A 2: 85,184,006 (GRCm39) T88I probably benign Het
Or6c210 A T 10: 129,496,475 (GRCm39) I267F probably benign Het
Parvb G T 15: 84,187,635 (GRCm39) D248Y probably damaging Het
Pcdh11x A T X: 119,310,315 (GRCm39) H586L possibly damaging Het
Phactr2 T C 10: 13,137,572 (GRCm39) E120G probably damaging Het
Ppfibp2 A T 7: 107,342,171 (GRCm39) Q775L probably damaging Het
Rcbtb1 A G 14: 59,467,443 (GRCm39) Y427C probably damaging Het
Rftn2 A T 1: 55,250,351 (GRCm39) C131* probably null Het
Rigi A G 4: 40,229,536 (GRCm39) S83P probably damaging Het
Rps6ka2 A G 17: 7,556,402 (GRCm39) D474G probably benign Het
Rsbn1l T C 5: 21,156,734 (GRCm39) E17G probably damaging Het
Ryr2 T C 13: 11,720,585 (GRCm39) M2688V probably benign Het
Slc22a18 C A 7: 143,046,574 (GRCm39) probably benign Het
Smarcc1 A G 9: 109,961,194 (GRCm39) probably benign Het
Soat2 T C 15: 102,070,550 (GRCm39) V451A probably damaging Het
Sptlc2 A T 12: 87,356,667 (GRCm39) probably benign Het
Tada1 C T 1: 166,220,203 (GRCm39) L308F probably damaging Het
Tango2 A T 16: 18,128,731 (GRCm39) probably null Het
Tbc1d15 A T 10: 115,065,111 (GRCm39) V158D probably damaging Het
Tmx2 A T 2: 84,503,588 (GRCm39) probably benign Het
Tpte T A 8: 22,795,874 (GRCm39) I79K probably benign Het
Trav6-1 A G 14: 52,876,199 (GRCm39) I40V probably benign Het
Trgv3 A G 13: 19,427,423 (GRCm39) Y102C probably damaging Het
Ubash3a T C 17: 31,450,455 (GRCm39) S377P possibly damaging Het
Vmn2r7 T C 3: 64,600,446 (GRCm39) D575G probably damaging Het
Vps41 A G 13: 19,037,649 (GRCm39) D704G possibly damaging Het
Vwa5a T C 9: 38,638,259 (GRCm39) S261P possibly damaging Het
Zc3hav1 A G 6: 38,317,264 (GRCm39) V112A probably damaging Het
Other mutations in Dpp10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01592:Dpp10 APN 1 123,262,099 (GRCm39) missense probably damaging 1.00
IGL01618:Dpp10 APN 1 123,295,596 (GRCm39) missense probably benign
IGL02101:Dpp10 APN 1 123,339,555 (GRCm39) missense probably damaging 1.00
IGL02284:Dpp10 APN 1 123,973,103 (GRCm39) splice site probably benign
IGL02324:Dpp10 APN 1 123,295,531 (GRCm39) missense probably benign 0.02
IGL02391:Dpp10 APN 1 123,578,087 (GRCm39) missense probably damaging 0.98
IGL02469:Dpp10 APN 1 123,339,532 (GRCm39) missense probably benign 0.01
IGL02501:Dpp10 APN 1 123,613,999 (GRCm39) missense possibly damaging 0.93
IGL02522:Dpp10 APN 1 123,351,381 (GRCm39) missense probably benign 0.24
IGL02672:Dpp10 APN 1 123,304,376 (GRCm39) missense probably benign 0.45
IGL03034:Dpp10 APN 1 123,269,348 (GRCm39) missense probably damaging 1.00
PIT1430001:Dpp10 UTSW 1 123,268,911 (GRCm39) splice site probably benign
R0104:Dpp10 UTSW 1 123,295,572 (GRCm39) missense probably benign 0.00
R0114:Dpp10 UTSW 1 123,413,821 (GRCm39) missense probably benign 0.07
R0242:Dpp10 UTSW 1 123,326,275 (GRCm39) missense possibly damaging 0.56
R0242:Dpp10 UTSW 1 123,326,275 (GRCm39) missense possibly damaging 0.56
R0682:Dpp10 UTSW 1 123,832,852 (GRCm39) missense probably damaging 0.98
R0815:Dpp10 UTSW 1 123,360,658 (GRCm39) critical splice donor site probably null
R1549:Dpp10 UTSW 1 123,269,109 (GRCm39) critical splice acceptor site probably null
R1742:Dpp10 UTSW 1 123,372,935 (GRCm39) missense probably damaging 1.00
R1859:Dpp10 UTSW 1 123,281,333 (GRCm39) missense possibly damaging 0.47
R1991:Dpp10 UTSW 1 123,832,833 (GRCm39) missense probably null 1.00
R1992:Dpp10 UTSW 1 123,832,833 (GRCm39) missense probably null 1.00
R2079:Dpp10 UTSW 1 123,360,721 (GRCm39) missense probably damaging 1.00
R2882:Dpp10 UTSW 1 123,372,932 (GRCm39) missense probably damaging 1.00
R2974:Dpp10 UTSW 1 123,339,434 (GRCm39) splice site probably benign
R3827:Dpp10 UTSW 1 123,339,519 (GRCm39) missense possibly damaging 0.56
R3852:Dpp10 UTSW 1 123,413,653 (GRCm39) nonsense probably null
R3876:Dpp10 UTSW 1 123,281,216 (GRCm39) missense probably damaging 0.98
R3899:Dpp10 UTSW 1 123,281,286 (GRCm39) missense probably damaging 1.00
R4735:Dpp10 UTSW 1 123,326,356 (GRCm39) missense probably benign 0.15
R4922:Dpp10 UTSW 1 123,305,882 (GRCm39) missense probably benign 0.44
R5457:Dpp10 UTSW 1 123,339,539 (GRCm39) missense possibly damaging 0.51
R5599:Dpp10 UTSW 1 123,832,803 (GRCm39) missense probably damaging 0.99
R5913:Dpp10 UTSW 1 123,312,018 (GRCm39) missense probably damaging 1.00
R5979:Dpp10 UTSW 1 123,312,012 (GRCm39) critical splice donor site probably null
R6378:Dpp10 UTSW 1 123,339,468 (GRCm39) missense probably damaging 1.00
R6429:Dpp10 UTSW 1 123,295,330 (GRCm39) missense possibly damaging 0.72
R6505:Dpp10 UTSW 1 123,264,580 (GRCm39) missense probably damaging 0.99
R6776:Dpp10 UTSW 1 123,295,385 (GRCm39) nonsense probably null
R6894:Dpp10 UTSW 1 123,264,593 (GRCm39) missense probably damaging 1.00
R6951:Dpp10 UTSW 1 123,269,379 (GRCm39) missense possibly damaging 0.93
R7182:Dpp10 UTSW 1 123,268,880 (GRCm39) missense probably benign 0.15
R7246:Dpp10 UTSW 1 123,262,106 (GRCm39) missense probably damaging 1.00
R7297:Dpp10 UTSW 1 123,281,157 (GRCm39) nonsense probably null
R7375:Dpp10 UTSW 1 123,295,524 (GRCm39) missense probably benign
R7387:Dpp10 UTSW 1 123,268,869 (GRCm39) missense probably benign 0.01
R7661:Dpp10 UTSW 1 123,312,681 (GRCm39) missense probably damaging 1.00
R8065:Dpp10 UTSW 1 123,280,389 (GRCm39) missense probably benign
R8067:Dpp10 UTSW 1 123,280,389 (GRCm39) missense probably benign
R8260:Dpp10 UTSW 1 123,614,024 (GRCm39) missense probably benign
R8324:Dpp10 UTSW 1 123,781,901 (GRCm39) missense probably benign 0.02
R8373:Dpp10 UTSW 1 123,781,958 (GRCm39) missense possibly damaging 0.94
R8434:Dpp10 UTSW 1 123,360,739 (GRCm39) missense probably damaging 1.00
R9068:Dpp10 UTSW 1 123,360,667 (GRCm39) missense probably damaging 1.00
R9104:Dpp10 UTSW 1 123,339,484 (GRCm39) missense probably damaging 1.00
R9477:Dpp10 UTSW 1 123,304,370 (GRCm39) missense possibly damaging 0.46
R9492:Dpp10 UTSW 1 123,281,159 (GRCm39) missense probably damaging 1.00
R9524:Dpp10 UTSW 1 123,264,611 (GRCm39) missense probably damaging 1.00
R9576:Dpp10 UTSW 1 123,269,409 (GRCm39) missense probably damaging 1.00
R9631:Dpp10 UTSW 1 123,269,432 (GRCm39) missense probably damaging 1.00
R9736:Dpp10 UTSW 1 123,262,088 (GRCm39) missense possibly damaging 0.64
X0019:Dpp10 UTSW 1 123,326,314 (GRCm39) missense possibly damaging 0.88
X0020:Dpp10 UTSW 1 123,326,311 (GRCm39) missense probably benign 0.36
X0021:Dpp10 UTSW 1 123,360,721 (GRCm39) missense probably damaging 1.00
X0024:Dpp10 UTSW 1 123,312,015 (GRCm39) missense probably damaging 1.00
Z1176:Dpp10 UTSW 1 123,281,169 (GRCm39) nonsense probably null
Posted On 2015-04-16