Incidental Mutation 'IGL02458:Tada1'
ID 294490
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tada1
Ensembl Gene ENSMUSG00000026563
Gene Name transcriptional adaptor 1
Synonyms Tada1l, 2900026B15Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02458
Quality Score
Status
Chromosome 1
Chromosomal Location 166206736-166221190 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 166220203 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 308 (L308F)
Ref Sequence ENSEMBL: ENSMUSP00000027846 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027846] [ENSMUST00000128861] [ENSMUST00000131487] [ENSMUST00000135673] [ENSMUST00000148243] [ENSMUST00000169324]
AlphaFold Q99LM9
Predicted Effect probably damaging
Transcript: ENSMUST00000027846
AA Change: L308F

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000027846
Gene: ENSMUSG00000026563
AA Change: L308F

DomainStartEndE-ValueType
Pfam:SAGA-Tad1 6 131 3.2e-18 PFAM
Pfam:SAGA-Tad1 116 194 4.8e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000128861
SMART Domains Protein: ENSMUSP00000118270
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131487
SMART Domains Protein: ENSMUSP00000116477
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000135673
SMART Domains Protein: ENSMUSP00000120352
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
KRAB 47 107 1.53e-19 SMART
Pfam:BrkDBD 195 247 2.1e-29 PFAM
CENPB 256 323 3.93e-21 SMART
Pfam:DDE_1 355 567 1.4e-55 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138148
Predicted Effect probably benign
Transcript: ENSMUST00000148243
SMART Domains Protein: ENSMUSP00000118877
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 12 27 N/A INTRINSIC
low complexity region 113 124 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000169324
SMART Domains Protein: ENSMUSP00000127395
Gene: ENSMUSG00000040596

DomainStartEndE-ValueType
low complexity region 6 18 N/A INTRINSIC
low complexity region 31 46 N/A INTRINSIC
KRAB 66 126 1.53e-19 SMART
Pfam:BrkDBD 214 266 8.7e-29 PFAM
CENPB 275 342 3.93e-21 SMART
Pfam:DDE_1 414 586 1.5e-48 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam25 A T 8: 41,206,844 (GRCm39) I37L probably benign Het
Alpk1 A G 3: 127,474,968 (GRCm39) probably null Het
Ankrd33 T C 15: 101,014,488 (GRCm39) F8L probably damaging Het
Avil A G 10: 126,852,222 (GRCm39) K669R probably benign Het
Bcor G T X: 11,914,749 (GRCm39) L1165I probably damaging Het
C7 A G 15: 5,088,871 (GRCm39) probably benign Het
Cc2d2a A G 5: 43,875,896 (GRCm39) I958V probably benign Het
Cenpe A T 3: 134,935,869 (GRCm39) K435* probably null Het
Chrna7 G A 7: 62,755,842 (GRCm39) L235F probably damaging Het
Col6a3 C A 1: 90,706,919 (GRCm39) V2065L unknown Het
Copb1 A T 7: 113,846,020 (GRCm39) N183K probably benign Het
Cpn2 G A 16: 30,079,653 (GRCm39) A16V probably benign Het
Cul1 A G 6: 47,502,542 (GRCm39) K769E possibly damaging Het
Deup1 C T 9: 15,503,656 (GRCm39) V302M probably benign Het
Dnah17 T C 11: 117,927,176 (GRCm39) K3871E probably damaging Het
Dnah6 A G 6: 73,004,431 (GRCm39) V3844A probably benign Het
Dnah7a A T 1: 53,657,487 (GRCm39) L763* probably null Het
Donson A T 16: 91,478,064 (GRCm39) W461R probably damaging Het
Dpp10 T C 1: 123,269,418 (GRCm39) I664V probably benign Het
Dusp8 T A 7: 141,636,484 (GRCm39) T369S probably benign Het
Dync2h1 A T 9: 7,117,422 (GRCm39) L56Q probably damaging Het
Ecd A T 14: 20,374,545 (GRCm39) S532T probably benign Het
Frg2f1 G A 4: 119,388,154 (GRCm39) T115I probably damaging Het
Gpatch2l A G 12: 86,335,735 (GRCm39) probably benign Het
Gtf3c2 T A 5: 31,316,867 (GRCm39) probably null Het
Haghl T C 17: 26,002,470 (GRCm39) probably benign Het
Hoxc8 A T 15: 102,901,181 (GRCm39) N208I probably damaging Het
Igf2 T C 7: 142,207,785 (GRCm39) D115G probably benign Het
Jag2 T A 12: 112,879,613 (GRCm39) D385V probably damaging Het
Laptm4b A G 15: 34,258,888 (GRCm39) H54R probably benign Het
Lrp2 A G 2: 69,352,117 (GRCm39) S640P probably damaging Het
Map3k8 A C 18: 4,334,660 (GRCm39) V328G probably damaging Het
Mfsd13a A G 19: 46,360,686 (GRCm39) E388G probably damaging Het
Ms4a13 G A 19: 11,149,292 (GRCm39) T168I probably benign Het
Mtg1 C A 7: 139,730,085 (GRCm39) Q294K probably benign Het
Myh3 C T 11: 66,987,766 (GRCm39) A1413V possibly damaging Het
Neo1 A T 9: 58,801,150 (GRCm39) probably benign Het
Ogfod3 T C 11: 121,091,749 (GRCm39) E119G probably benign Het
Or10ak9 A G 4: 118,726,497 (GRCm39) N173S possibly damaging Het
Or2t49 A T 11: 58,393,073 (GRCm39) M109K probably benign Het
Or4a77 A G 2: 89,487,692 (GRCm39) L31P probably damaging Het
Or5ak20 G A 2: 85,184,006 (GRCm39) T88I probably benign Het
Or6c210 A T 10: 129,496,475 (GRCm39) I267F probably benign Het
Parvb G T 15: 84,187,635 (GRCm39) D248Y probably damaging Het
Pcdh11x A T X: 119,310,315 (GRCm39) H586L possibly damaging Het
Phactr2 T C 10: 13,137,572 (GRCm39) E120G probably damaging Het
Ppfibp2 A T 7: 107,342,171 (GRCm39) Q775L probably damaging Het
Rcbtb1 A G 14: 59,467,443 (GRCm39) Y427C probably damaging Het
Rftn2 A T 1: 55,250,351 (GRCm39) C131* probably null Het
Rigi A G 4: 40,229,536 (GRCm39) S83P probably damaging Het
Rps6ka2 A G 17: 7,556,402 (GRCm39) D474G probably benign Het
Rsbn1l T C 5: 21,156,734 (GRCm39) E17G probably damaging Het
Ryr2 T C 13: 11,720,585 (GRCm39) M2688V probably benign Het
Slc22a18 C A 7: 143,046,574 (GRCm39) probably benign Het
Smarcc1 A G 9: 109,961,194 (GRCm39) probably benign Het
Soat2 T C 15: 102,070,550 (GRCm39) V451A probably damaging Het
Sptlc2 A T 12: 87,356,667 (GRCm39) probably benign Het
Tango2 A T 16: 18,128,731 (GRCm39) probably null Het
Tbc1d15 A T 10: 115,065,111 (GRCm39) V158D probably damaging Het
Tmx2 A T 2: 84,503,588 (GRCm39) probably benign Het
Tpte T A 8: 22,795,874 (GRCm39) I79K probably benign Het
Trav6-1 A G 14: 52,876,199 (GRCm39) I40V probably benign Het
Trgv3 A G 13: 19,427,423 (GRCm39) Y102C probably damaging Het
Ubash3a T C 17: 31,450,455 (GRCm39) S377P possibly damaging Het
Vmn2r7 T C 3: 64,600,446 (GRCm39) D575G probably damaging Het
Vps41 A G 13: 19,037,649 (GRCm39) D704G possibly damaging Het
Vwa5a T C 9: 38,638,259 (GRCm39) S261P possibly damaging Het
Zc3hav1 A G 6: 38,317,264 (GRCm39) V112A probably damaging Het
Other mutations in Tada1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01462:Tada1 APN 1 166,216,294 (GRCm39) missense probably damaging 1.00
R0959:Tada1 UTSW 1 166,216,198 (GRCm39) missense probably benign 0.13
R1442:Tada1 UTSW 1 166,214,319 (GRCm39) missense possibly damaging 0.90
R1586:Tada1 UTSW 1 166,214,319 (GRCm39) missense possibly damaging 0.90
R4790:Tada1 UTSW 1 166,219,523 (GRCm39) missense possibly damaging 0.87
R5344:Tada1 UTSW 1 166,207,081 (GRCm39) intron probably benign
R6782:Tada1 UTSW 1 166,217,541 (GRCm39) missense probably benign 0.25
R7254:Tada1 UTSW 1 166,216,217 (GRCm39) nonsense probably null
R7679:Tada1 UTSW 1 166,219,540 (GRCm39) missense probably benign
R7733:Tada1 UTSW 1 166,217,511 (GRCm39) missense probably damaging 0.99
R7831:Tada1 UTSW 1 166,217,442 (GRCm39) missense probably damaging 1.00
R9140:Tada1 UTSW 1 166,216,177 (GRCm39) missense probably benign 0.38
R9175:Tada1 UTSW 1 166,210,005 (GRCm39) missense probably damaging 0.98
R9657:Tada1 UTSW 1 166,214,312 (GRCm39) missense possibly damaging 0.69
Posted On 2015-04-16