Incidental Mutation 'IGL02466:Csnk2a2'
ID 294575
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Csnk2a2
Ensembl Gene ENSMUSG00000046707
Gene Name casein kinase 2, alpha prime polypeptide
Synonyms 1110035J23Rik, CK2
Accession Numbers
Essential gene? Possibly essential (E-score: 0.716) question?
Stock # IGL02466
Quality Score
Status
Chromosome 8
Chromosomal Location 96172724-96215505 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96203859 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 100 (D100G)
Ref Sequence ENSEMBL: ENSMUSP00000148404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056919] [ENSMUST00000212214] [ENSMUST00000212952]
AlphaFold O54833
Predicted Effect possibly damaging
Transcript: ENSMUST00000056919
AA Change: D100G

PolyPhen 2 Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000055919
Gene: ENSMUSG00000046707
AA Change: D100G

DomainStartEndE-ValueType
S_TKc 40 325 1.85e-77 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211980
Predicted Effect possibly damaging
Transcript: ENSMUST00000212214
AA Change: D100G

PolyPhen 2 Score 0.867 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212310
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212338
Predicted Effect probably benign
Transcript: ENSMUST00000212441
Predicted Effect probably benign
Transcript: ENSMUST00000212952
AA Change: D33G

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000212616
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212615
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Males homozygotes for a targeted null mutation of the minor catalytic subunit exhibit infertility with oligospermia and abnormally shaped spermatid nuclei. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,247,527 (GRCm39) F2425L probably benign Het
Adgre4 A T 17: 56,121,188 (GRCm39) Y418F probably benign Het
Adra1a G T 14: 66,875,322 (GRCm39) C99F probably damaging Het
Aox3 C A 1: 58,197,431 (GRCm39) H592Q probably benign Het
Cacna1f A G X: 7,495,644 (GRCm39) probably null Het
Cacna2d2 T A 9: 107,342,753 (GRCm39) I100N probably damaging Het
Cblif A T 19: 11,729,596 (GRCm39) N185I probably damaging Het
Ccr9 T A 9: 123,608,911 (GRCm39) C198S probably damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Col4a3 T A 1: 82,647,913 (GRCm39) C475S unknown Het
Cstf2t G A 19: 31,061,277 (GRCm39) G271E possibly damaging Het
Fbxw22 T C 9: 109,214,160 (GRCm39) R219G probably damaging Het
Homez A G 14: 55,095,559 (GRCm39) F50L probably damaging Het
Hspa4l C T 3: 40,707,657 (GRCm39) Q81* probably null Het
Ifi202b T C 1: 173,799,875 (GRCm39) D202G possibly damaging Het
Inava T C 1: 136,144,173 (GRCm39) probably null Het
Mansc1 T A 6: 134,587,814 (GRCm39) D121V probably damaging Het
Or13a24 A G 7: 140,154,684 (GRCm39) Y206C probably benign Het
Or4a27 T G 2: 88,559,739 (GRCm39) D68A probably damaging Het
Or51h5 T A 7: 102,577,723 (GRCm39) V296E possibly damaging Het
P2rx1 A T 11: 72,900,410 (GRCm39) probably null Het
Phactr4 A G 4: 132,104,483 (GRCm39) probably benign Het
Pus10 C T 11: 23,675,574 (GRCm39) T482I probably damaging Het
Scyl2 G T 10: 89,488,871 (GRCm39) Y206* probably null Het
Sell G A 1: 163,896,632 (GRCm39) probably null Het
Slfn10-ps C T 11: 82,921,090 (GRCm39) noncoding transcript Het
Ssh2 T C 11: 77,307,233 (GRCm39) probably benign Het
Tas2r117 A G 6: 132,779,963 (GRCm39) M34V probably benign Het
Vmn2r103 A T 17: 19,993,631 (GRCm39) T3S probably benign Het
Vmn2r73 A T 7: 85,522,084 (GRCm39) I85K probably damaging Het
Vps13b T C 15: 35,770,887 (GRCm39) V2110A possibly damaging Het
Zfp13 C T 17: 23,795,072 (GRCm39) A493T probably benign Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zfp592 G A 7: 80,673,746 (GRCm39) G237R probably damaging Het
Zkscan7 A G 9: 122,717,950 (GRCm39) E115G probably damaging Het
Zranb3 G A 1: 127,943,829 (GRCm39) T306M probably benign Het
Other mutations in Csnk2a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1452:Csnk2a2 UTSW 8 96,184,003 (GRCm39) splice site probably benign
R1717:Csnk2a2 UTSW 8 96,182,436 (GRCm39) splice site probably null
R4260:Csnk2a2 UTSW 8 96,184,027 (GRCm39) missense probably benign 0.01
R6062:Csnk2a2 UTSW 8 96,184,097 (GRCm39) missense possibly damaging 0.93
R7169:Csnk2a2 UTSW 8 96,215,006 (GRCm39) missense
R8124:Csnk2a2 UTSW 8 96,182,575 (GRCm39) missense
R8125:Csnk2a2 UTSW 8 96,182,575 (GRCm39) missense
R8126:Csnk2a2 UTSW 8 96,182,575 (GRCm39) missense
R8253:Csnk2a2 UTSW 8 96,215,005 (GRCm39) missense
Posted On 2015-04-16